Results 1 to 10 of about 7,013,774 (312)
Targeting cancer metabolism in the era of precision oncology
Nature Reviews Drug Discovery, 2021 One hundred years have passed since Warburg discovered alterations in cancer metabolism, more than 70 years since Sidney Farber introduced anti-folates that transformed the treatment of childhood leukaemia, and 20 years since metabolism was linked to ...
Joseph Salvino +2 more
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The PI3K–AKT network at the interface of oncogenic signalling and cancer metabolism
Nature Reviews Cancer, 2019 The altered metabolic programme of cancer cells facilitates their cell-autonomous proliferation and survival. In normal cells, signal transduction pathways control core cellular functions, including metabolism, to couple the signals from exogenous growth
Gerta Hoxhaj, Brendan Manning
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THE HALLMARKS OF CANCER METABOLISM: STILL EMERGING
Cell Metabolism, 2022 SUMMARY Metabolism of cancer cells is geared towards biomass production and proliferation. Since the metabolic resources within the local tissue are finite, this can lead to nutrient depletion and accumulation of metabolic waste.
N. Pavlova, Jiajun Zhu, C. Thompson
semanticscholar +1 more source
Communications Biology, 2022 The nucleosome-binding proteins HMGN1 and HMGN2 prefer acetylated nucleosomes at H3K27ac and the loss of this interaction alters binding of transcription factors to chromatin.
Shaofei Zhang +5 more
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Cell, 2023 The uptake and metabolism of nutrients supports fundamental cellular process from bioenergetics to biomass production and cell fate regulation. Initial studies on metabolic networks in animal tissues revealed major differences in how tumors and normal ...
Lydia W. S. Finley
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Withaferin A alleviates fulminant hepatitis by targeting macrophage and NLRP3
Cell Death and Disease, 2021 Fulminant hepatitis (FH) is an incurable clinical syndrome where novel therapeutics are warranted. Withaferin A (WA), isolated from herb Withania Somnifera, is a hepatoprotective agent.
Yangliu Xia +4 more
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Emerging therapies in cancer metabolism.
Cell Metabolism, 2023 Metabolic reprogramming in cancer is not only a biological hallmark but also reveals treatment vulnerabilities. Numerous metabolic molecules have shown promise as treatment targets to impede tumor progression in preclinical studies, with some advancing ...
Yi Xiao +6 more
semanticscholar +1 more source
The role of m6A RNA methylation in cancer metabolism
Molecular Cancer, 2022 Metabolic reprogramming is one of the main characteristics of malignant tumors, which is due to the flexible changes of cell metabolism that can meet the needs of cell growth and maintain the homeostasis of tissue environments.
Yuanyuan An, Huayan Duan
semanticscholar +1 more source
Cancer Metabolism: The Role of ROS in DNA Damage and Induction of Apoptosis in Cancer Cells
Metabolites, 2023 Cancer is a huge challenge for people worldwide. High reactive oxygen species (ROS) levels are a recognized hallmark of cancer and an important aspect of cancer treatment research.
Yongxia Zhao +10 more
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Signaling pathways in cancer metabolism: mechanisms and therapeutic targets
Signal Transduction and Targeted Therapy, 2023 A wide spectrum of metabolites (mainly, the three major nutrients and their derivatives) can be sensed by specific sensors, then trigger a series of signal transduction pathways and affect the expression levels of genes in epigenetics, which is called ...
Mengshu You +8 more
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