Results 1 to 10 of about 771,169 (120)

H3K27ac nucleosomes facilitate HMGN localization at regulatory sites to modulate chromatin binding of transcription factors

Communications Biology, 2022
The nucleosome-binding proteins HMGN1 and HMGN2 prefer acetylated nucleosomes at H3K27ac and the loss of this interaction alters binding of transcription factors to chromatin.
Shaofei Zhang, Yuri Postnikov, Alexei Lobanov, Takashi Furusawa, Tao Deng, Michael Bustin   +5 more
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Withaferin A alleviates fulminant hepatitis by targeting macrophage and NLRP3

Cell Death and Disease, 2021
Fulminant hepatitis (FH) is an incurable clinical syndrome where novel therapeutics are warranted. Withaferin A (WA), isolated from herb Withania Somnifera, is a hepatoprotective agent.
Yangliu Xia, Ping Wang, Nana Yan, Frank J. Gonzalez, Tingting Yan   +4 more
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The cancer metabolic reprogramming and immune response

Molecular Cancer, 2021
The overlapping metabolic reprogramming of cancer and immune cells is a putative determinant of the antitumor immune response in cancer. Increased evidence suggests that cancer metabolism not only plays a crucial role in cancer signaling for sustaining ...
Longzheng Xia, Linda Oyang, Jinguan Lin, Shiming Tan, Yaqian Han, Nayiyuan Wu, Pin Yi, Lu Tang, Qing Pan, Shan Rao, Jiaxin Liang, Yanyan Tang, Min Su, Xia Luo, Yiqing Yang, Yingrui Shi, Hui Wang, Yujuan Zhou, Qianjin Liao   +18 more
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The human microbial exposome: expanding the Exposome-Explorer database with gut microbial metabolites

Scientific Reports, 2023
Metabolites produced by the gut microbiota play an important role in the cross-talk with the human host. Many microbial metabolites are biologically active and can pass the gut barrier and make it into the systemic circulation, where they form the gut ...
Vanessa Neveu, Geneviève Nicolas, Adam Amara, Reza M. Salek, Augustin Scalbert   +4 more
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Mechanisms of buffer therapy resistance

Neoplasia: An International Journal for Oncology Research, 2014
Many studies have shown that the acidity of solid tumors contributes to local invasion and metastasis. Oral pH buffers can specifically neutralize the acidic pH of tumors and reduce the incidence of local invasion and metastatic formation in multiple ...
Kate M. Bailey, Jonathan W. Wojtkowiak, Heather H. Cornnell, Maria C. Ribeiro, Yoganand Balagurunathan, Arig Ibrahim Hashim, Robert J. Gillies   +6 more
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Metabolic reprogramming and epigenetic modifications in cancer: from the impacts and mechanisms to the treatment potential

Experimental and Molecular Medicine, 2023
Metabolic reprogramming and epigenetic modifications are hallmarks of cancer cells. In cancer cells, metabolic pathway activity varies during tumorigenesis and cancer progression, indicating regulated metabolic plasticity.
Xuemeng Xu, Qiu Peng, Xianjie Jiang, Shiming Tan, Yiqing Yang, Wenjuan Yang, Yaqian Han, Yuyu Chen, Linda Oyang, Jinguan Lin, Longzheng Xia, Mingjing Peng, Nayiyuan Wu, Yanyan Tang, Jinyun Li, Qianjin Liao, Yujuan Zhou   +16 more
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Exosomal cargos-mediated metabolic reprogramming in tumor microenvironment

Journal of Experimental & Clinical Cancer Research, 2023
Metabolic reprogramming is one of the hallmarks of cancer. As nutrients are scarce in the tumor microenvironment (TME), tumor cells adopt multiple metabolic adaptations to meet their growth requirements.
Shiming Tan, Yiqing Yang, Wenjuan Yang, Yaqian Han, Lisheng Huang, Ruiqian Yang, Zifan Hu, Yi Tao, Lin Liu, Yun Li, Linda Oyang, Jinguan Lin, Qiu Peng, Xianjie Jiang, Xuemeng Xu, Longzheng Xia, Mingjing Peng, Nayiyuan Wu, Yanyan Tang, Deliang Cao, Qianjin Liao, Yujuan Zhou   +21 more
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Secretoglobin 3A2 eliminates human cancer cells through pyroptosis

Cell Death Discovery, 2021
Non-canonical inflammasome activation that recognizes intracellular lipopolysaccharide (LPS) causes pyroptosis, the inflammatory death of innate immune cells.
Shigetoshi Yokoyama, Shun Nakayama, Lei Xu, Aprile L. Pilon, Shioko Kimura   +4 more
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Recent advances in cancer metabolism: a technological perspective

Experimental and Molecular Medicine, 2018
Cancer: Tools for mapping malignant metabolism Researchers now have access to a rapidly growing number of tools for probing the metabolic abnormalities associated with tumor growth. Unrestrained growth puts special demands on cancer cells, and scientists
Yun Pyo Kang, Nathan P. Ward, Gina M. DeNicola   +2 more
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Prioritization and functional validation of target genes from single-cell transcriptomics studies

Communications Biology, 2023
Translation of academic results into clinical practice is a formidable unmet medical need. Single-cell RNA-sequencing (scRNA-seq) studies generate long descriptive ranks of markers with predicted biological function, but without functional validation, it
Liliana Sokol, Anne Cuypers, Anh-Co K. Truong, Ann Bouché, Katleen Brepoels, Joris Souffreau, Katerina Rohlenova, Stefan Vinckier, Luc Schoonjans, Guy Eelen, Mieke Dewerchin, Laura P.M.H. de Rooij, Peter Carmeliet   +12 more
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