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Metabolism of Cancer Stem Cell
, 2023 Nowadays, cancer is considered as a stem cell disease of altered metabolism. The metabolism of cancer stem cells (CSCs) is less well characterized with some research evidence indicating that they display increased dependence on glycoly-sis while others ...
Auwal, A +4 more
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Reprogramming of fatty acid metabolism in cancer.
, 2020 A common feature of cancer cells is their ability to rewire their metabolism to sustain the production of ATP and macromolecules needed for cell growth, division and survival.
Poulogiannis, G, Koundouros, N
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Mitochondrial metabolism and cancer [PDF]
Cell Research, 2017 Glycolysis has long been considered as the major metabolic process for energy production and anabolic growth in cancer cells. Although such a view has been instrumental for the development of powerful imaging tools that are still used in the clinics, it is now clear that mitochondria play a key role in oncogenesis. Besides exerting central bioenergetic
Porporato, Paolo Ettore +4 more
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Cancer Cell Metabolism: One Hallmark, Many Faces [PDF]
, 2012 Cancer cells must rewire cellular metabolism to satisfy the demands of growth and proliferation. Although many of the metabolic alterations are largely similar to those in normal proliferating cells, they are aberrantly driven in cancer by a combination ...
Sabatini, David +3 more
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Metabolism in cancer metastasis [PDF]
International Journal of Cancer, 2015 Cancer metabolism has regained substantial research interest over recent years. The focus has been mostly on the primary tumor, while metabolic adjustments during dissemination have been less extensively researched. Deadhesion impairs glucose transport and brings about an ATP deficit that leads to apoptosis.
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Estrogen Receptor a Promotes Breast Cancer by Reprogramming Choline Metabolism [PDF]
, 2016 Estrogen receptor alpha (ER alpha) is a key regulator of breast growth and breast cancer development. Here, we report how ER alpha impacts these processes by reprogramming metabolism in malignant breast cells.
Sinha, Indranil, +33 more
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Metabolism and Colorectal Cancer
Annual Review of Pathology: Mechanisms of Disease, 2023 Reprogrammed metabolism is a hallmark of colorectal cancer (CRC). CRC cells are geared toward rapid proliferation, requiring nutrients and the removal of cellular waste in nutrient-poor environments. Intestinal stem cells (ISCs), the primary cell of origin for CRCs, must adapt their metabolism along the adenoma-carcinoma sequence to the unique ...
Joseph C, Sedlak +2 more
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The Heterogeneity of Cancer Metabolism
, 2021 This open access volume will introduce recent discoveries in cancer metabolism since the publication of the first edition in 2018, providing readers with an up-to-date understanding of developments in the field. Genetic alterations in cancer, in addition
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Ovarian Cancer and Glutamine Metabolism
, 2023 Cancer cells are known to have a distinct metabolic profile and to exhibit significant changes in a variety of metabolic mechanisms compared to normal cells, particularly glycolysis and glutaminolysis, in order to cover their increased energy ...
Athanasios Chionis +19 more
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Polyamine metabolism and cancer [PDF]
Journal of Cellular and Molecular Medicine, 2003 AbstractPolyamines are aliphatic cations present in all cells. In normal cells, polyamine levels are intricately controlled by biosynthetic and catabolic enzymes. The biosynthetic enzymes are ornithine decarboxylase, S‐adenosylmethionine decarboxylase, spermidine synthase, and spermine synthase.
Thresia, Thomas, T J, Thomas
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