Results 21 to 30 of about 7,013,774 (312)
Stearoyl coenzyme A desaturase-1: multitasker in cancer, metabolism, and ferroptosis.
Trends in Cancer, 2023 Cancer progression is a highly balanced process and is maintained by a sequence of finely tuned metabolic pathways. Stearoyl coenzyme A desaturase-1 (SCD1), the fatty enzyme that converts saturated fatty acids into monounsaturated fatty acids, is a ...
U. Sen, Charles Coleman, T. Sen
semanticscholar +1 more source
Targeting Cancer Metabolism [PDF]
Clinical Cancer Research, 2012 Abstract The understanding that oncogenes can have profound effects on cellular metabolism and the discovery of mutations and alterations in several metabolism-related enzymes—isocitrate dehydrogenase 1 (IDH1), isocitrate dehydrogenase 2 (IDH2), succinate dehydrogenase (SDH), fumarate hydratase (FH), and pyruvate kinase M2 (PKM2)—has ...
Beverly A, Teicher +2 more
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Scientific Reports, 2023 Metabolites produced by the gut microbiota play an important role in the cross-talk with the human host. Many microbial metabolites are biologically active and can pass the gut barrier and make it into the systemic circulation, where they form the gut ...
Vanessa Neveu +4 more
doaj +1 more source
Frontiers in Immunology, 2023 Adenosine monophosphate-activated protein kinase (AMPK) is a key metabolic sensor that is pivotal for the maintenance of cellular energy homeostasis. AMPK contributes to diverse metabolic and physiological effects besides its fundamental role in glucose ...
C. Keerthana +6 more
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Disorders of cancer metabolism: The therapeutic potential of cannabinoids.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2022 Abnormal energy metabolism, as one of the important hallmarks of cancer, was induced by multiple carcinogenic factors and tumor-specific microenvironments.
Ding-ya Sun +4 more
semanticscholar +1 more source
THE EMERGING HALLMARKS OF CANCER METABOLISM
Cell Metabolism, 2016 Tumorigenesis is dependent on the reprogramming of cellular metabolism as both direct and indirect consequence of oncogenic mutations. A common feature of cancer cell metabolism is the ability to acquire necessary nutrients from a frequently nutrient ...
N. Pavlova, C. Thompson
semanticscholar +1 more source
Mechanisms of buffer therapy resistance
Neoplasia: An International Journal for Oncology Research, 2014 Many studies have shown that the acidity of solid tumors contributes to local invasion and metastasis. Oral pH buffers can specifically neutralize the acidic pH of tumors and reduce the incidence of local invasion and metastatic formation in multiple ...
Kate M. Bailey +6 more
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Experimental and Molecular Medicine, 2023 Metabolic reprogramming and epigenetic modifications are hallmarks of cancer cells. In cancer cells, metabolic pathway activity varies during tumorigenesis and cancer progression, indicating regulated metabolic plasticity.
Xuemeng Xu +16 more
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Spotlight on GOT2 in Cancer Metabolism
OncoTargets and Therapy, 2023 GOT2 is at the nexus of several critical metabolic pathways in homeostatic cellular and dysregulated cancer metabolism. Despite this, recent work has emphasized the remarkable plasticity of cancer cells to employ compensatory pathways when GOT2 is ...
S. Kerk +5 more
semanticscholar +1 more source
Epigenetics and cancer metabolism [PDF]
Cancer Letters, 2015 Cancer cells adapt their metabolism to support proliferation and survival. A hallmark of cancer, this alteration is characterized by dysfunctional metabolic enzymes, changes in nutrient availability, tumor microenvironment and oncogenic mutations. Metabolic rewiring in cancer is tightly connected to changes at the epigenetic level. Enzymes that mediate
Johnson, C. +3 more
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