Results 41 to 50 of about 7,013,774 (312)
Recent advances in cancer metabolism: a technological perspective
Experimental and Molecular Medicine, 2018 Cancer: Tools for mapping malignant metabolism Researchers now have access to a rapidly growing number of tools for probing the metabolic abnormalities associated with tumor growth. Unrestrained growth puts special demands on cancer cells, and scientists
Yun Pyo Kang +2 more
doaj +1 more source
Cancer Metabolism: Phenotype, Signaling and Therapeutic Targets
Cells, 2020 Aberrant metabolism is a major hallmark of cancer. Abnormal cancer metabolism, such as aerobic glycolysis and increased anabolic pathways, has important roles in tumorigenesis, metastasis, drug resistance, and cancer stem cells.
J. Park, Woo Yang Pyun, H. Park
semanticscholar +1 more source
The emerging regulatory roles of long non-coding RNAs implicated in cancer metabolism.
Molecular Therapy, 2021 Compared to normal cells, cancer cells exhibit specific metabolic characteristics that facilitate the growth and metastasis of cancer. It is now widely appreciated that long noncoding RNAs (lncRNAs) exert extensive regulatory effects on a spectrum of ...
Yongcan Xu +6 more
semanticscholar +1 more source
Metabolic transformation in cancer [PDF]
Carcinogenesis, 2009 In 2000, Douglas Hanahan and Robert Weinberg published a review detailing the six hallmarks of cancer. These are six phenotypes that a tumour requires in order to become a fully fledged malignancy: persistent growth signals, evasion of apoptosis, insensitivity to anti-growth signals, unlimited replicative potential, angiogenesis and invasion and ...
Daniel A, Tennant +3 more
openaire +2 more sources
Prioritization and functional validation of target genes from single-cell transcriptomics studies
Communications Biology, 2023 Translation of academic results into clinical practice is a formidable unmet medical need. Single-cell RNA-sequencing (scRNA-seq) studies generate long descriptive ranks of markers with predicted biological function, but without functional validation, it
Liliana Sokol +12 more
doaj +1 more source
Diet and exercise in cancer metabolism
Cancer Discovery, 2022 Diet and exercise are modifiable lifestyle factors known to have a major influence on metabolism. Clinical practice addresses diseases of altered metabolism such as diabetes or hypertension by altering these factors.
J. Locasale
semanticscholar +1 more source
The function of prohibitins in mitochondria and the clinical potentials
Cancer Cell International, 2022 Prohibitins (PHBs) are a class of highly evolutionarily conserved proteins that widely distribute in prokaryotes and eukaryotes. PHBs function in cell growth and proliferation or differentiation, regulating metabolism and signaling pathways.
Linda Oyang +14 more
doaj +1 more source
Journal of Lipid Research, 2018 PPARα (PPARA), expressed in most oxidative tissues, is a major regulator of lipid homeostasis; hepatic PPARA plays a critical role during the adaptive fasting response by promoting FA oxidation (FAO).
Chad N. Brocker +8 more
doaj +1 more source
100 years of the Warburg effect: A cancer metabolism endeavor.
CellIf you are a scientist and you only know one thing about tumor metabolism, it's likely the Warburg effect. But who was Otto Warburg, and how did his discoveries regarding the metabolism of tumors shape our current thinking about the metabolic needs of ...
S. Fendt
semanticscholar +1 more source