Results 51 to 60 of about 7,013,774 (312)
Flavonoids Targeting HIF-1: Implications on Cancer Metabolism
Cancers, 2021 Simple Summary This comprehensive review discusses the anticancer effects of plant phenolic compounds, known as flavonoids, through the targeting of HIF-1 and critical enzymes contributing to the Warburg effect.
Marek Samec +16 more
semanticscholar +1 more source
Cold Spring Harbor Symposia on Quantitative Biology, 2011 Although the generation of a distinctive metabolic profile is a well-known aspect of cancer, the significance of these adaptations and their potential for exploitation for anticancer therapy has not been fully appreciated until recently. Many oncogenic changes known to affect intracellular signaling pathways play an active role in mediating these ...
R A, Cairns +3 more
openaire +2 more sources
Nature CommunicationsCysteine metabolism occurs across cellular compartments to support diverse biological functions and prevent the induction of ferroptosis. Though the disruption of cytosolic cysteine metabolism is implicated in this form of cell death, it is unknown ...
Nathan P. Ward +6 more
doaj +1 more source
Direct control of lysosomal catabolic activity by mTORC1 through regulation of V-ATPase assembly
Nature Communications, 2022 mTORC1 blocks lysosomal nutrient generation. Here, the authors show that mTORC1 inactivation triggers V-ATPase assembly, which rapidly initiates lysosomal acidification and degradation of protein contents throughout the lysosomal population.
Edoardo Ratto +6 more
doaj +1 more source
Is Cancer a Metabolic Disease? [PDF]
The American Journal of Pathology, 2014 Although cancer has historically been viewed as a disorder of proliferation, recent evidence has suggested that it should also be considered a metabolic disease. Growing tumors rewire their metabolic programs to meet and even exceed the bioenergetic and biosynthetic demands of continuous cell growth. The metabolic profile observed in cancer cells often
openaire +3 more sources
The Intratumoral Heterogeneity of Cancer Metabolism.
Advances in Experimental Medicine and Biology, 2021 Cancer is one of the deadliest diseases in the world, causing over half a million deaths a year in the USA alone. Despite recent advances made in the field of cancer biology and the therapies that have been developed [1, 2], it is clear that more ...
Karim B. Nabi, A. Le
semanticscholar +1 more source
Autophagy, Metabolism, and Cancer [PDF]
Clinical Cancer Research, 2015 Abstract Macroautophagy (autophagy hereafter) captures intracellular proteins and organelles and degrades them in lysosomes. The degradation breakdown products are released from lysosomes and recycled into metabolic and biosynthetic pathways.
Eileen, White +2 more
openaire +2 more sources
Pediatric Blood &Cancer, EarlyView.ABSTRACT Primary cutaneous anaplastic large cell lymphoma (pcALCL) is a rare pediatric CD30‐positive T‐cell lymphoproliferative disorder with an excellent prognosis, but its genomic drivers are poorly defined. We report three children with skin‐limited disease demonstrating striking molecular heterogeneity, including NPM::ALK, NUP214::FRK, and a novel ...
Shoshana Greenberger +7 more
wiley +1 more source
VDAC Modulation of Cancer Metabolism: Advances and Therapeutic Challenges
Frontiers in Physiology, 2021 Most anionic metabolites including respiratory substrates, glycolytic adenosine triphosphate (ATP), and small cations that enter mitochondria, and mitochondrial ATP moving to the cytosol, cross the outer mitochondrial membrane (OMM) through voltage ...
Kareem A. Heslop +2 more
semanticscholar +1 more source
Pediatric Blood &Cancer, EarlyView.ABSTRACT Introduction The use of herbal medical preparation (HMP) is rising among pediatric oncology patients, often to manage treatment‐related symptoms. Their effectiveness remains uncertain, and the risk of herb–drug interactions is underestimated.
Orianne Mahot +6 more
wiley +1 more source