Results 51 to 60 of about 4,807,572 (318)

Cancer Cell Metabolism [PDF]

Cold Spring Harbor Symposia on Quantitative Biology, 2011
Although the generation of a distinctive metabolic profile is a well-known aspect of cancer, the significance of these adaptations and their potential for exploitation for anticancer therapy has not been fully appreciated until recently. Many oncogenic changes known to affect intracellular signaling pathways play an active role in mediating these ...
R A, Cairns, I, Harris, S, McCracken, T W, Mak   +3 more
openaire   +2 more sources

Bone and Soft Tissue Neoplasms in Infants Versus Older Children: A Report From the Cancer in Young People in Canada Program

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background and Aims Infant bone and soft tissue neoplasms present distinct clinical challenges and lack large‐scale data to inform treatment decisions. This study aims to characterize bone and soft tissue neoplasms in infants in Canada and to compare their outcomes with those of older pediatric patients.
Samuel Sassine, Hallie Coltin, Maria Kondyli, Monia Marzouki, Nicolas Prud'homme, Nida Usmani, Rebecca J. Deyell, Lesleigh Abbott, Tony H. Truong, Sapna Oberoi, Ketan Kulkarni, Josée Brossard, Lynette Bowes, Paul Gibson, Sarah McKillop, Roona Sinha, Lillian Sung, Catherine Vezina, Laura Wheaton, Alexandra P. Zorzi, Marie‐Claude Pelland‐Marcotte, Thai Hoa Tran   +21 more
wiley   +1 more source

Therapeutic Apheresis in Nigeria: A Multi‐Center Summary of Abstracts From the Inaugural Nigerian Society for Apheresis Scientific Meeting

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Background Therapeutic apheresis (TA) is an established treatment modality for hematologic, neurologic, and immunologic disorders, yet access remains severely limited in sub‐Saharan Africa. Donor apheresis, including platelet apheresis collection from healthy donors, represents an important complementary modality supporting blood product ...
Nosa Bazuaye, Chimezie Okwuonu, Evelyn Idam, Folasade Adelekan‐Popoola, Shakirat Gold‐Olufadi, Olufunto Olufela Kalejaiye, Abdullateef Ogala, Zinnah Aloziem, Blossom Amamchukwu, Patience Elimia, Mkpoikanabasi Obot‐Obot, Henry Mbakwe, Praises Maduagwuna, Olatunji Akinrodoye, Chiamaka Anyanwu, Benjamin Anyanwu, Adedamola Akinsiku, Oluwatoyin A. Akinsiku, Muzamil O. Hassan, Fatiu A. Arogundade, Olalekan E. Ojo, Homayemem Weli, Jesupelumi Adenihun, Aderemi Adelaja, Ebun Bamgboye, Olalekan Olatise, Ade E. Faponle, Ayoola Odeyemi, Michael Muoka, Stephen Asaolu, Qudrat Busari, Blessing Dawudu, Michael Naiyeju, Rasheed A. Balogun   +33 more
wiley   +1 more source

Lysosomal recruitment of TSC2 is a universal response to cellular stress

Nature Communications, 2016
In response to amino acid and growth factor removal the TSC1/2 complex translocates to the lysosome to inactivate mTOR and inhibit cell growth. Here, the authors have shown that other cellular stresses also trigger this translocation to the lysosome ...
Constantinos Demetriades, Monika Plescher, Aurelio A. Teleman   +2 more
doaj   +1 more source

Prognostic significance of folate metabolism polymorphisms for lung cancer. [PDF]

, 2007
Functional nonsynonymous single-nucleotide polymorphisms (nsSNPs) of folate metabolism genes can influence the methylation of tumour suppressor genes, thereby potentially impacting on tumour behaviour.
El Galta, R, Rudd, MF, Houlston, RS, T Eisen, R el Galta, E L Webb, R S Houlston, Matakidou, A, Bridle, H, M F Rudd, H Bridle, Eisen, T, A Matakidou, Webb, EL   +13 more
core   +1 more source

Cholesterol Metabolism in Pancreatic Cancer

, 2023
Pancreatic cancer’s substantial impact on cancer-related mortality, responsible for 8% of cancer deaths and ranking fourth in the US, persists despite advancements, with a five-year relative survival rate of only 11%.
Artur Rebelo, Jörg Kleeff, Yoshiaki Sunami   +2 more
core   +1 more source

Safety of Daprodustat for the Treatment of Chronic Kidney Disease Anemia: Final Analysis of a Multicenter Postmarketing Surveillance Study in Japan

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Introduction This final analysis of a multicenter, prospective postmarketing surveillance study evaluated the safety of daprodustat in patients with chronic kidney disease anemia in routine clinical practice in Japan. Methods Patients who initiated daprodustat between September 2020 and July 2022 were registered.
Tadao Akizawa, Kyomi Kanaya, Kiyomi Aizawa, Masanori Onoki, Hirofumi Ozeki, Kazuko Suzuki, Ai Hayashi, Tomohiko Asamura   +7 more
wiley   +1 more source

Investigation of the heterogeneity of cancer cells using single cell Ca2+ profiling

Cell Communication and Signaling
Background Calcium (Ca2+) is an essential second messenger that controls numerous cellular functions. Characteristics of intracellular Ca2+ oscillations define Ca2+ signatures representatives of the phenotype of a cell.
Amélie E. Bura, Camille Caussette, Maxime Guéguinou, Dorine Bellanger, Alison Robert, Mathilde Cancel, Margot Lacouette-Rata, Gaëlle Fromont, Christophe Vandier, Karine Mahéo, Thierry Brouard, David Crottès   +11 more
doaj   +1 more source

Molecular Aspects of Cancer Cell Metabolism: Altered Glycolysis and Lipid Metabolism

, 2020
Cancer cells have high proliferation rate and therefore require continuous energy source. Metabolic alteration in pathways like glycolysis and lipid metabolism gives a better chance of survival for cancer cells.
Garg Neha., Verma Deepanshu, Patel Sandesh. K.   +2 more
core   +1 more source

Glutamine Metabolism in Cancer

, 2021
AbstractMetabolism is a fundamental process for all cellular functions. For decades, there has been growing evidence of a relationship between metabolism and malignant cell proliferation. Unlike normal differentiated cells, cancer cells have reprogrammed metabolism in order to fulfill their energy requirements. These cells display crucial modifications
Ting, Li, Christopher, Copeland, Anne, Le   +2 more
openaire   +2 more sources