Results 31 to 40 of about 7,013,774 (312)
Hacking Cancer Metabolism [PDF]
Cell Metabolism, 2016 Otto Warburg is generally credited to be the “father” of cancer metabolism for his seminal discovery of how cancer cells predominantly generate energy through glycolysis rather than oxidative phosphorylation, even in the presence of oxygen. While it was initially thought that the sole function of aerobic glycolysis was to quickly provide ATP for ...
Anne, Granger +2 more
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Exosomal cargos-mediated metabolic reprogramming in tumor microenvironment
Journal of Experimental & Clinical Cancer Research, 2023 Metabolic reprogramming is one of the hallmarks of cancer. As nutrients are scarce in the tumor microenvironment (TME), tumor cells adopt multiple metabolic adaptations to meet their growth requirements.
Shiming Tan +21 more
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Overview of Cancer Metabolism and Signaling Transduction
International Journal of Molecular Sciences, 2022 Despite the remarkable progress in cancer treatment up to now, we are still far from conquering the disease. The most substantial change after the malignant transformation of normal cells into cancer cells is the alteration in their metabolism.
H. Chae, Seong-Tshool Hong
semanticscholar +1 more source
Secretoglobin 3A2 eliminates human cancer cells through pyroptosis
Cell Death Discovery, 2021 Non-canonical inflammasome activation that recognizes intracellular lipopolysaccharide (LPS) causes pyroptosis, the inflammatory death of innate immune cells.
Shigetoshi Yokoyama +4 more
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Arginine Signaling and Cancer Metabolism
Cancers, 2021 Simple Summary In this review, we describe arginine’s role as a signaling metabolite, epigenetic regulator and mitochondrial modulator in cancer cells, and summarize recent progress in the application of arginine deprivation as a cancer therapy. Abstract
Chia-Lin Chen +4 more
semanticscholar +1 more source
Metabolism in cancer metastasis [PDF]
International Journal of Cancer, 2015 Cancer metabolism has regained substantial research interest over recent years. The focus has been mostly on the primary tumor, while metabolic adjustments during dissemination have been less extensively researched. Deadhesion impairs glucose transport and brings about an ATP deficit that leads to apoptosis.
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Cancers, 2021 Simple Summary Raman spectroscopy and imaging are label-free, non-destructive techniques to study cellular metabolism with subcellular spatial resolution.
Jiabao Xu +6 more
semanticscholar +1 more source
The role of ubiquitination and deubiquitination in cancer metabolism
Molecular Cancer, 2020 Metabolic reprogramming, including enhanced biosynthesis of macromolecules, altered energy metabolism, and maintenance of redox homeostasis, is considered a hallmark of cancer, sustaining cancer cell growth.
Tianshui Sun, Zhuonan Liu, Qing Yang
semanticscholar +1 more source
Impact of cancer metabolism on therapy resistance - Clinical implications.
Drug resistance updates, 2021 Despite an increasing arsenal of anticancer therapies, many patients continue to have poor outcomes due to the therapeutic failures and tumor relapses. Indeed, the clinical efficacy of anticancer therapies is markedly limited by intrinsic and/or acquired
A. Gonçalves +9 more
semanticscholar +1 more source
Mitochondrial metabolism and cancer [PDF]
Cell Research, 2017 Glycolysis has long been considered as the major metabolic process for energy production and anabolic growth in cancer cells. Although such a view has been instrumental for the development of powerful imaging tools that are still used in the clinics, it is now clear that mitochondria play a key role in oncogenesis. Besides exerting central bioenergetic
Porporato, Paolo Ettore +4 more
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