Results 31 to 40 of about 4,807,572 (318)
Cancer stem cell metabolism. [PDF]
, 2016 Cancer is now viewed as a stem cell disease. There is still no consensus on the metabolic characteristics of cancer stem cells, with several studies indicating that they are mainly glycolytic and others pointing instead to mitochondrial metabolism as ...
Martinez-Outshoorn, Ubaldo E. +12 more
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Targeting Redox Metabolism in Pancreatic Cancer
, 2021 International audienceCell metabolism is reprogrammed in cancer cells to meet their high bioenergetics and biosynthetic demands. This metabolic reprogramming is accompanied by alterations in redox metabolism, characterized by accumulation of reactive ...
Gabriela Reyes-Castellanos +5 more
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The function of prohibitins in mitochondria and the clinical potentials
Cancer Cell International, 2022 Prohibitins (PHBs) are a class of highly evolutionarily conserved proteins that widely distribute in prokaryotes and eukaryotes. PHBs function in cell growth and proliferation or differentiation, regulating metabolism and signaling pathways.
Linda Oyang +14 more
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Peroxisome Metabolism in Cancer
, 2020 Peroxisomes are metabolic organelles involved in lipid metabolism and cellular redoxbalance. Peroxisomal function is central to fatty acid oxidation, ether phospholipid synthesis, bile acidsynthesis, and reactive oxygen species homeostasis.
Jung Ae Kim, Jung-Ae Kim
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Exploiting cancer metabolism [PDF]
Science, 2017 Cancer Therapy Cancer-specific cell surface proteins can be targeted for the delivery of therapeutic agents. However, specific proteins may not always be expressed by a tumor. Wang et al. overcome this challenge by designing sugars to selectively label cancer cells.
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Journal of Lipid Research, 2018 PPARα (PPARA), expressed in most oxidative tissues, is a major regulator of lipid homeostasis; hepatic PPARA plays a critical role during the adaptive fasting response by promoting FA oxidation (FAO).
Chad N. Brocker +8 more
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Autophagy, Metabolism, and Cancer [PDF]
Clinical Cancer Research, 2015 Abstract Macroautophagy (autophagy hereafter) captures intracellular proteins and organelles and degrades them in lysosomes. The degradation breakdown products are released from lysosomes and recycled into metabolic and biosynthetic pathways.
Eileen, White +2 more
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, 2016 [[abstract]]Epigenetic dysregulation is one of the mechanisms involved in ovarian cancer carcinogenesis. Recently identified a new epigenetic modulator ten-eleven translocation protein 1 (TET1), a DNA dioxygenase which is believed in DNA demethylation ...
Chen, LY;Huang, RL;Yan, PS;Huang, TS;Liao, YP;Chou, JL;Lin, JMJ;Chao, TK;Chan, MWY;Chang, WSW;Lai, HC
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RB/E2F1 as a Master Regulator of Cancer Cell Metabolism in Advanced Disease.
, 2021 Loss of the retinoblastoma (RB) tumor suppressor protein is a critical step in reprogramming biological networks that drive cancer progression, although mechanistic insight has been largely limited to the impact of RB loss on cell-cycle regulation. Here,
Vasilevskaya, IA +49 more
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Imaging Cancer Metabolism [PDF]
Biomolecules & Therapeutics, 2018 It is widely accepted that altered metabolism contributes to cancer growth and has been described as a hallmark of cancer. Our view and understanding of cancer metabolism has expanded at a rapid pace, however, there remains a need to study metabolic dependencies of human cancer in vivo. Recent studies have sought to utilize multi-modality imaging (MMI)
Momcilovic, Milica +1 more
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