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Journal of Translational Medicine, 2021 © The Author(s) 2021. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the ...
Violena Pietrobon
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Fundamentals of cancer metabolism [PDF]
Science Advances, 2016 Researchers provide a conceptual framework to understand current knowledge of the fundamentals of cancer metabolism. Tumors reprogram pathways of nutrient acquisition and metabolism to meet the bioenergetic, biosynthetic, and redox demands of malignant ...
R. Deberardinis, N. Chandel
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Cancer metabolism and carcinogenesis
Experimental Hematology & OncologyMetabolic reprogramming is an emerging hallmark of cancer cells, enabling them to meet increased nutrient and energy demands while withstanding the challenging microenvironment.
Jianqiang Yang +3 more
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Metabolism and Colorectal Cancer
Annual Review of Pathology: Mechanisms of Disease, 2023 Reprogrammed metabolism is a hallmark of colorectal cancer (CRC). CRC cells are geared toward rapid proliferation, requiring nutrients and the removal of cellular waste in nutrient-poor environments. Intestinal stem cells (ISCs), the primary cell of origin for CRCs, must adapt their metabolism along the adenoma-carcinoma sequence to the unique ...
Joseph C, Sedlak +2 more
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Altered metabolism in cancer [PDF]
BMC Biology, 2010 Cancer cells have different metabolic requirements from their normal counterparts. Understanding the consequences of this differential metabolism requires a detailed understanding of glucose metabolism and its relation to energy production in cancer cells. A recent study in BMC Systems Biology by Vasquez et al.
Locasale, Jason Wei, Cantley, Lewis C.
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Metabolism and Brain Cancer [PDF]
Clinics, 2011 Cellular energy metabolism is one of the main processes affected during the transition from normal to cancer cells, and it is a crucial determinant of cell proliferation or cell death. As a support for rapid proliferation, cancer cells choose to use glycolysis even in the presence of oxygen (Warburg effect) to fuel macromolecules for the synthesis of ...
Marie, Suely Kazue Nagahashi +1 more
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Sirtuins, Metabolism, and Cancer [PDF]
Frontiers in Pharmacology, 2012 More than a decade ago, sirtuins were discovered as a highly conserved family of NAD(+)-dependent enzymes that extend lifespan in lower organisms. In mammals, sirtuins are key regulators of stress responses and metabolism, influencing a range of diseases, including diabetes, neurodegeneration, and cancer. In recent years, new functions of sirtuins have
Martinez-Pastor, Barbara +1 more
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An Overview: The Diversified Role of Mitochondria in Cancer Metabolism
International Journal on Biological Sciences, 2023 Mitochondria are intracellular organelles involved in energy production, cell metabolism and cell signaling. They are essential not only in the process of ATP synthesis, lipid metabolism and nucleic acid metabolism, but also in tumor development and ...
Yue-ting Liu +10 more
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The cancer metabolic reprogramming and immune response
Molecular Cancer, 2021 The overlapping metabolic reprogramming of cancer and immune cells is a putative determinant of the antitumor immune response in cancer. Increased evidence suggests that cancer metabolism not only plays a crucial role in cancer signaling for sustaining ...
Longzheng Xia +18 more
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To metabolomics and beyond: a technological portfolio to investigate cancer metabolism
Signal Transduction and Targeted Therapy, 2023 Tumour cells have exquisite flexibility in reprogramming their metabolism in order to support tumour initiation, progression, metastasis and resistance to therapies.
Federica Danzi +6 more
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