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Cancer as a Metabolic Disorder [PDF]
International Journal of Molecular Sciences, 2022 Cancer has long been considered a genetic disease characterized by a myriad of mutations that drive cancer progression. Recent accumulating evidence indicates that the dysregulated metabolism in cancer cells is more than a hallmark of cancer but may be the underlying cause of the tumor. Most of the well-characterized oncogenes or tumor suppressor genes
Jones Gyamfi +2 more
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Sirtuins, Metabolism, and Cancer [PDF]
Frontiers in Pharmacology, 2012 More than a decade ago, sirtuins were discovered as a highly conserved family of NAD(+)-dependent enzymes that extend lifespan in lower organisms. In mammals, sirtuins are key regulators of stress responses and metabolism, influencing a range of diseases, including diabetes, neurodegeneration, and cancer. In recent years, new functions of sirtuins have
Martinez-Pastor, Barbara +1 more
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Altered metabolism in cancer [PDF]
BMC Biology, 2010 Cancer cells have different metabolic requirements from their normal counterparts. Understanding the consequences of this differential metabolism requires a detailed understanding of glucose metabolism and its relation to energy production in cancer cells. A recent study in BMC Systems Biology by Vasquez et al.
Locasale, Jason Wei, Cantley, Lewis C.
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Breast Cancer Subtypes Underlying EMT-Mediated Catabolic Metabolism [PDF]
, 2020 Efficient catabolic metabolism of adenosine triphosphate (ATP) and reduced nicotinamide adenine dinucleotide phosphate (NADPH) is essentially required for cancer cell survival, especially in metastatic cancer progression.
김남희 +15 more
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Metabolism and Brain Cancer [PDF]
Clinics, 2011 Cellular energy metabolism is one of the main processes affected during the transition from normal to cancer cells, and it is a crucial determinant of cell proliferation or cell death. As a support for rapid proliferation, cancer cells choose to use glycolysis even in the presence of oxygen (Warburg effect) to fuel macromolecules for the synthesis of ...
Marie, Suely Kazue Nagahashi +1 more
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Targeting Cancer Metabolism [PDF]
Clinical Cancer Research, 2012 Abstract The understanding that oncogenes can have profound effects on cellular metabolism and the discovery of mutations and alterations in several metabolism-related enzymes—isocitrate dehydrogenase 1 (IDH1), isocitrate dehydrogenase 2 (IDH2), succinate dehydrogenase (SDH), fumarate hydratase (FH), and pyruvate kinase M2 (PKM2)—has ...
Beverly A, Teicher +2 more
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Metabolic Syndrome and Cancer [PDF]
Metabolic Syndrome and Related Disorders, 2009 Since its first description by Reavan in 1988, accepted criteria for clinical identification of the components of metabolic syndrome have been promulgated by the National Cholesterol Education Program/Adult Treatment Panel III (NCEP/ATP III) and the World Health Organization (WHO) as well as the International Diabetes Federation (IDF), and the American
Pooja, Pothiwala +2 more
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Metabolism and microenvironment in cancer plasticity [PDF]
, 2016 Major contributions of the 2nd annual meeting of the International Society of Cancer Metabolism, held in Venice, September 16–19, 2015, are here described and discussed.
Stock, CM +18 more
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MYC, Metabolism, and Cancer [PDF]
Cancer Discovery, 2015 Abstract The MYC oncogene encodes a transcription factor, MYC, whose broad effects make its precise oncogenic role enigmatically elusive. The evidence to date suggests that MYC triggers selective gene expression amplification to promote cell growth and proliferation.
Zachary E, Stine +4 more
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Modelling of mitochondrial metabolism in breast cancer [PDF]
, 2022 Recently two different metabolic phenotypes have been discovered in breast cancer cells. As increasing evidence shows how metabolism is directly connected to cancer invasiveness, it is of interest to identify which enzymes lead to the expression of each ...
Zenere, Alberto
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