De novo serine biosynthesis is protective in mitochondrial disease [PDF]
Cell ReportsSummary: The importance of serine as a metabolic regulator is well known for tumors and is also gaining attention in degenerative diseases. Recent data indicate that de novo serine biosynthesis is an integral component of the metabolic response to ...
Nahid A Khan, Christopher B Jackson
exaly +9 more sources
m6A/IGF2BP3-driven serine biosynthesis fuels AML stemness and metabolic vulnerability [PDF]
Nature CommunicationsMetabolic reprogramming of amino acids represents a vulnerability in cancer cells, yet the mechanisms underlying serine metabolism in acute myeloid leukemia (AML) and leukemia stem/initiating cells (LSCs/LICs) remain unclear.
Feng Huang +19 more
doaj +3 more sources
The malate-aspartate shuttle is important for de novo serine biosynthesis [PDF]
Cell Reports, 2023 Summary: The malate-aspartate shuttle (MAS) is a redox shuttle that transports reducing equivalents across the inner mitochondrial membrane while recycling cytosolic NADH to NAD+.
Melissa H. Broeks +11 more
doaj +2 more sources
An archaeal ADP-dependent serine kinase involved in cysteine biosynthesis and serine metabolism [PDF]
Nature Communications, 2016 Archaea metabolism has unique adaptations to hostile environments. Here Makino et al. describe an unusual ADP-dependent kinase that phosphorylates free serine to O-phosphoserine and participates in an additional cysteine biosynthetic pathway in the ...
Yuki Makino +6 more
doaj +3 more sources
Epigenetic regulation of serine biosynthesis by PHF8 during neurogenesis [PDF]
EMBO ReportsProgenitor proliferation during neurodevelopment requires tight coordination of epigenetic regulation and metabolism. However, the crosstalk between these processes remains poorly understood.
Marta H Artes +16 more
doaj +2 more sources
ΔNp63α drives serine synthesis to promote carboplatin resistance in NSCLC [PDF]
Cell Death and DiseaseSerine metabolism is a critical vulnerability in cancer; however, its role in mediating therapeutic resistance in non-small cell lung cancer (NSCLC) remains incompletely understood.
Liyuan Deng +6 more
doaj +2 more sources
The phosphorylated pathway of serine biosynthesis is crucial for indolic glucosinolate biosynthesis and plant growth promotion conferred by the root endophyte Colletotrichum tofieldiae [PDF]
Plant Molecular Biology, 2021 Henning Frerigmann +2 more
exaly +2 more sources
, 2023 De novo l-serine biosynthesis in the mammalian astrocytes proceeds via a linear, three-step pathway (the phosphorylated pathway) catalysed by 3-phosphoglycerate dehydrogenase (PHGDH), phosphoserine aminotransferase (PSAT) and phosphoserine phosphatase ...
Giulia Murtas +17 more
core +2 more sources
De novo serine biosynthesis from glucose predicts sex-specific response to antifolates in non-small cell lung cancer cell lines. [PDF]
iScience, 2022 Lung cancer is the leading cause of cancer-related death. Intriguingly, males with non-small cell lung cancer (NSCLC) have a higher mortality rate than females. Here, we investigated the role of serine metabolism as a predictive marker for sensitivity to
Sponagel J +4 more
europepmc +3 more sources
Deficits in Prenatal Serine Biosynthesis Underlie the Mitochondrial Dysfunction Associated with the Autism-Linked FMR1 Gene. [PDF]
Int J Mol Sci, 2021 Fifty-five to two hundred CGG repeats (called a premutation, or PM) in the 5'-UTR of the FMR1 gene are generally unstable, often expanding to a full mutation (>200) in one generation through maternal inheritance, leading to fragile X syndrome, a ...
Nolin SL +4 more
europepmc +2 more sources