De novo serine biosynthesis is protective in mitochondrial disease
Cell ReportsSummary: The importance of serine as a metabolic regulator is well known for tumors and is also gaining attention in degenerative diseases. Recent data indicate that de novo serine biosynthesis is an integral component of the metabolic response to ...
Christopher Jackson, Nahid A Khan
exaly +3 more sources
An archaeal ADP-dependent serine kinase involved in cysteine biosynthesis and serine metabolism [PDF]
Nature Communications, 2016 Archaea metabolism has unique adaptations to hostile environments. Here Makino et al. describe an unusual ADP-dependent kinase that phosphorylates free serine to O-phosphoserine and participates in an additional cysteine biosynthetic pathway in the ...
Yuki Makino +6 more
doaj +3 more sources
The phosphorylated pathway of serine biosynthesis is crucial for indolic glucosinolate biosynthesis and plant growth promotion conferred by the root endophyte Colletotrichum tofieldiae [PDF]
Plant Molecular Biology, 2021 Stephan Krueger, Henning Frerigmann
exaly +2 more sources
Serine biosynthesis as a novel therapeutic target for dilated cardiomyopathy. [PDF]
Eur Heart J, 2022 Abstract Aims Genetic dilated cardiomyopathy (DCM) is a leading cause of heart failure. Despite significant progress in understanding the genetic aetiologies of DCM, the molecular mechanisms underlying the pathogenesis of familial DCM remain unknown, translating to a lack of disease-specific ...
Perea-Gil I +21 more
europepmc +3 more sources
ATF3 promotes the serine synthesis pathway and tumor growth under dietary serine restriction
Cell Reports, 2021 Summary: The serine synthesis pathway (SSP) involving metabolic enzymes phosphoglycerate dehydrogenase (PHGDH), phosphoserine aminotransferase 1 (PSAT1), and phosphoserine phosphatase (PSPH) drives intracellular serine biosynthesis and is indispensable ...
Xingyao Li +9 more
doaj +1 more source
Serine Biosynthesis Pathway Supports MYC–miR-494–EZH2 Feed-Forward Circuit Necessary to Maintain Metabolic and Epigenetic Reprogramming of Burkitt Lymphoma Cells [PDF]
Cancers, 2020 Anna Szumera-Cieckiewicz +2 more
exaly +2 more sources
Expression of Serine Biosynthesis Pathway Genes in Breast Muscles of Iranian Native Turkeys with Divergent Feed Efficiency [PDF]
پژوهشهای علوم دامی ایران, 2022 Introduction: Feed is the main cost part of poultry production. High feed efficiency poultry produce less feed and less excrement per unit weight gain. Therefore, a comprehensive understanding of the biological mechanisms that control feed efficiency is ...
Zahra Pezeshkian +3 more
doaj +1 more source
PLoS Genetics, 2020 Sphingolipids are abundant and essential molecules in eukaryotes that have crucial functions as signaling molecules and as membrane components. Sphingolipid biosynthesis starts in the endoplasmic reticulum with the condensation of serine and palmitoyl ...
Bianca M Esch +10 more
doaj +1 more source
Parallel analysis of global garlic gene expression and alliin content following leaf wounding
BMC Plant Biology, 2021 Background Allium sativum (garlic) is an economically important food source and medicinal plant rich in sulfides and other protective substances such as alliin, the precursor of allicin biosynthesis. Cysteine, serine and sulfur is the precursor of alliin
Xuqin Yang +11 more
doaj +1 more source
The malate-aspartate shuttle is important for de novo serine biosynthesis
Cell Reports, 2023 Summary: The malate-aspartate shuttle (MAS) is a redox shuttle that transports reducing equivalents across the inner mitochondrial membrane while recycling cytosolic NADH to NAD+.
Melissa H. Broeks +11 more
doaj +1 more source