De novo serine biosynthesis is protective in mitochondrial disease [PDF]
Cell ReportsSummary: The importance of serine as a metabolic regulator is well known for tumors and is also gaining attention in degenerative diseases. Recent data indicate that de novo serine biosynthesis is an integral component of the metabolic response to ...
Christopher B Jackson, Nahid A Khan
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Cell Reports, 2017 Targeting defects in metabolism is an underutilized strategy for the treatment of cancer. Arginine auxotrophy resulting from the silencing of argininosuccinate synthetase 1 (ASS1) is a common metabolic alteration reported in a broad range of aggressive ...
Jason M Held +2 more
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m6A/IGF2BP3-driven serine biosynthesis fuels AML stemness and metabolic vulnerability [PDF]
Nature CommunicationsMetabolic reprogramming of amino acids represents a vulnerability in cancer cells, yet the mechanisms underlying serine metabolism in acute myeloid leukemia (AML) and leukemia stem/initiating cells (LSCs/LICs) remain unclear.
Feng Huang +19 more
doaj +2 more sources
Epigenetic regulation of serine biosynthesis by PHF8 during neurogenesis [PDF]
EMBO ReportsProgenitor proliferation during neurodevelopment requires tight coordination of epigenetic regulation and metabolism. However, the crosstalk between these processes remains poorly understood.
Marta H Artes +16 more
doaj +2 more sources
In Vivo Evidence for Serine Biosynthesis-Defined Sensitivity of Lung Metastasis, but Not of Primary Breast Tumors, to mTORC1 Inhibition [PDF]
Molecular Cell, 2021 Gianmarco Rinaldi +2 more
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The phosphorylated pathway of serine biosynthesis is crucial for indolic glucosinolate biosynthesis and plant growth promotion conferred by the root endophyte Colletotrichum tofieldiae [PDF]
Plant Molecular Biology, 2021 Stephan Krueger +2 more
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Serine Biosynthesis Pathway Supports MYC–miR-494–EZH2 Feed-Forward Circuit Necessary to Maintain Metabolic and Epigenetic Reprogramming of Burkitt Lymphoma Cells [PDF]
Cancers, 2020 Anna Szumera-Cieckiewicz +2 more
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ATF3 promotes the serine synthesis pathway and tumor growth under dietary serine restriction
Cell Reports, 2021 Summary: The serine synthesis pathway (SSP) involving metabolic enzymes phosphoglycerate dehydrogenase (PHGDH), phosphoserine aminotransferase 1 (PSAT1), and phosphoserine phosphatase (PSPH) drives intracellular serine biosynthesis and is indispensable ...
Xingyao Li +9 more
doaj +1 more source
Expression of Serine Biosynthesis Pathway Genes in Breast Muscles of Iranian Native Turkeys with Divergent Feed Efficiency [PDF]
پژوهشهای علوم دامی ایران, 2022 Introduction: Feed is the main cost part of poultry production. High feed efficiency poultry produce less feed and less excrement per unit weight gain. Therefore, a comprehensive understanding of the biological mechanisms that control feed efficiency is ...
Zahra Pezeshkian +3 more
doaj +1 more source
PLoS Genetics, 2020 Sphingolipids are abundant and essential molecules in eukaryotes that have crucial functions as signaling molecules and as membrane components. Sphingolipid biosynthesis starts in the endoplasmic reticulum with the condensation of serine and palmitoyl ...
Bianca M Esch +10 more
doaj +1 more source