Results 141 to 150 of about 29,721,904 (163)
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Downregulation of Phosphoserine aminotransferase 1 promotes tumorigenesis in Glioblastoma
The FASEB Journal, 2020Glioblastoma (GBM) is a typical brain tumor with survival below ten percent at 5 years after diagnosis. The genetic alternation and histological features are integrated into the classification of gliomas for better clinical management of GBM.
Yung-chieh Chan +3 more
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Cancer Research, 2018
Abstract Metastasis and endocrine resistance are two factors that complicate therapeutic intervention in breast cancer patients and lead to poorer overall survival. Metastasis is known to be responsible for 90% of cancer related deaths, and is especially prevalent in triple negative breast cancer (TNBC); while endocrine resistance can ...
Stephanie Metcalf +4 more
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Abstract Metastasis and endocrine resistance are two factors that complicate therapeutic intervention in breast cancer patients and lead to poorer overall survival. Metastasis is known to be responsible for 90% of cancer related deaths, and is especially prevalent in triple negative breast cancer (TNBC); while endocrine resistance can ...
Stephanie Metcalf +4 more
openaire +1 more source
2023
Ein wesentliches Merkmal von Tumorzellen stellt die Reprogrammierung des Zellmetabolismus dar. Auch die komplexe Genese aggressiver Non-Hodgkin-Lymphome wie dem diffus großzelligen B-Zell-Lymphom (DLBCL) geht mit einem Umbau des zellulären Stoffwechsels einher.
Harms, Wilken +5 more
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Ein wesentliches Merkmal von Tumorzellen stellt die Reprogrammierung des Zellmetabolismus dar. Auch die komplexe Genese aggressiver Non-Hodgkin-Lymphome wie dem diffus großzelligen B-Zell-Lymphom (DLBCL) geht mit einem Umbau des zellulären Stoffwechsels einher.
Harms, Wilken +5 more
openaire +2 more sources
Biotechnology Journal, 2019 Phosphoserine aminotransferase (SerC) from Escherichia coli (E. coli) MG1655 is engineered to catalyze the deamination of homoserine to 4-hydroxy-2-ketobutyrate, a key reaction in producing 1,3-propanediol (1,3-PDO) from glucose in a novel glycerol ...
An-Ping Zeng
exaly +3 more sources
Cancer Research, 2015
Abstract With an estimated 700,000 new cases per year, hepatocellular carcinoma (HCC) represents the fifth commonest cancer and is the third leading cause of cancer death worldwide. Its 5-year survival rate after surgery is only 5-6%.
Zhaobing Ding +11 more
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Abstract With an estimated 700,000 new cases per year, hepatocellular carcinoma (HCC) represents the fifth commonest cancer and is the third leading cause of cancer death worldwide. Its 5-year survival rate after surgery is only 5-6%.
Zhaobing Ding +11 more
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Clinical & Experimental Metastasis, 2019
Breast cancer is the second leading cause of cancer-related deaths among women and 90% of these mortalities can be attributed to progression to metastatic disease. In particular, triple negative breast cancer (TNBC) is extremely aggressive and frequently metastasizes to multiple organs. As TNBCs are categorized by their lack of hormone receptors, these
Stephanie Metcalf +6 more
openaire +2 more sources
Breast cancer is the second leading cause of cancer-related deaths among women and 90% of these mortalities can be attributed to progression to metastatic disease. In particular, triple negative breast cancer (TNBC) is extremely aggressive and frequently metastasizes to multiple organs. As TNBCs are categorized by their lack of hormone receptors, these
Stephanie Metcalf +6 more
openaire +2 more sources
Archives of Biochemistry and Biophysics
Endoplasmic reticulum stress and synthesis of serine are essential for tumor growth, but the mechanism of their interaction is not clarified yet. The overarching goal of this work was to investigate the impact of ERN1 (endoplasmic reticulum to nucleus signaling 1) inhibition on the expression of serine synthesis genes in U87MG glioblastoma cells ...
Oleksandr H. Minchenko +6 more
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Endoplasmic reticulum stress and synthesis of serine are essential for tumor growth, but the mechanism of their interaction is not clarified yet. The overarching goal of this work was to investigate the impact of ERN1 (endoplasmic reticulum to nucleus signaling 1) inhibition on the expression of serine synthesis genes in U87MG glioblastoma cells ...
Oleksandr H. Minchenko +6 more
openaire +2 more sources
The FASEB Journal, 2017
Cellular production of serine provides precursors for numerous anabolic reactions, particularly for proteins and nucleic acid synthesis and for one carbon metabolism, and this pathway has been demonstrated to be elevated in many different cancer types.
Brian F Clem +5 more
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Cellular production of serine provides precursors for numerous anabolic reactions, particularly for proteins and nucleic acid synthesis and for one carbon metabolism, and this pathway has been demonstrated to be elevated in many different cancer types.
Brian F Clem +5 more
openaire +1 more source