Results 41 to 50 of about 68,387 (225)

Mendelian randomization analysis identifies causal associations between serum lipidomic profile, amino acid biomarkers and sepsis

Heliyon
Background: Sepsis is a life-threatening condition marked by a severe systemic response to infection, leading to widespread inflammation, cellular signaling disruption, and metabolic dysregulation. The role of lipid and amino acid metabolism in sepsis is
Zi-gang Zhu, Jia-wei Ma, Dan-dan Ji, Qian-qian Li, Xin-yu Diao, Jie Bao   +5 more
doaj   +1 more source

Phosphotransferase-dependent accumulation of (p)ppGpp in response to glutamine deprivation in Caulobacter crescentus

Nature Communications, 2016
The small molecule (p)ppGpp is commonly produced by bacteria as a signal of nutrient starvation. Here, Ronneau et al. show that (p)ppGpp accumulation in the model bacterium Caulobacter crescentusis modulated by a nitrogen-related phosphotransferase ...
Séverin Ronneau, Kenny Petit, Xavier De Bolle, Régis Hallez   +3 more
doaj   +1 more source

Cajanin Stilbene Acid Inhibited Vancomycin-Resistant Enterococcus by Inhibiting Phosphotransferase System

Frontiers in Pharmacology, 2020
Antimicrobial resistance has become a serious threat to human and animal health, and vancomycin-resistant Enterococcus has become an important nosocomial infection pathogen, causing thousands of deaths each year.
Shengnan Tan, Shengnan Tan, Xin Hua, Xin Hua, Zheyong Xue, Zheyong Xue, Zheyong Xue, Jianzhang Ma   +7 more
doaj   +1 more source

Unlocking nitrogen regulation: structural insights into the NifL‐NifA complex and prospects for engineered diazotrophs

The FEBS Journal, EarlyView.
The urgent need for sustainable agriculture places biological nitrogen fixation at the forefront of current biotechnological research. Plant growth‐promoting rhizobacteria play crucial roles in agriculture by enhancing nutrient absorption, regulating hormonal balance, and providing reduced nitrogen to plants. Among these, diazotrophic bacteria, such as
Edileusa Cristina Marques Gerhardt, Khaled A. Selim   +1 more
wiley   +1 more source

Author Correction: Nuclear lipid droplets derive from a lipoprotein precursor and regulate phosphatidylcholine synthesis

Nature Communications, 2019
The original version of this Article contained errors in the Abstract and Introduction, whereby CCTα was incorrectly defined as an abbreviation of CDP-choline diacylglycerol phosphotransferase α, instead of CTP:phosphocholine cytidylyltransferase α. This
Kamil Sołtysik, Yuki Ohsaki, Tsuyako Tatematsu, Jinglei Cheng, Toyoshi Fujimoto   +4 more
doaj   +1 more source

Multi‐Omics Signatures of Periodontitis and Periodontal Therapy on the Oral and Gut Microbiome

Journal of Periodontal Research, EarlyView.
This multi‐omics study integrates shotgun metagenomics and NMR metabolomics to reveal coordinated microbial and metabolic signatures of periodontitis across the oral–gut axis. Non‐surgical periodontal therapy partially restored ecological and functional balance, supporting oral health as a modifiable driver of systemic microbial homeostasis.
Giacomo Baima, Shareef Dabdoub, Vivek Thumbigere‐Math, Davide Giuseppe Ribaldone, Gian Paolo Caviglia, Leonardo Tenori, Linda Fantato, Alessia Vignoli, Mario Romandini, Ilario Ferrocino, Mario Aimetti   +10 more
wiley   +1 more source

Sugar-mediated regulation of a c-di-GMP phosphodiesterase in Vibrio cholerae

Nature Communications, 2019
Carbon sources can modulate biofilm formation and host colonization in Vibrio cholerae. Here, Heo et al. show that this process is mediated by a component of the PEP:carbohydrate phosphotransferase system (PTS), which regulates c-di-GMP hydrolysis by ...
Kyoo Heo, Young-Ha Park, Kyung-Ah Lee, Joonwon Kim, Hyeong-In Ham, Byung-Gee Kim, Won-Jae Lee, Yeong-Jae Seok   +7 more
doaj   +1 more source

Upregulated ethanolamine phospholipid synthesis via selenoprotein I is required for effective metabolic reprogramming during T cell activation

Molecular Metabolism, 2021
Objective: T cell activation triggers metabolic reprogramming to meet increased demands for energy and metabolites required for cellular proliferation. Ethanolamine phospholipid synthesis has emerged as a regulator of metabolic shifts in stem cells and ...
Chi Ma, FuKun W. Hoffmann, Michael P. Marciel, Kathleen E. Page, Melodie A. Williams-Aduja, Ellis N.L. Akana, Greg S. Gojanovich, Mariana Gerschenson, Johann Urschitz, Stefan Moisyadi, Vedbar S. Khadka, Sharon Rozovsky, Youping Deng, F. David Horgen, Peter R. Hoffmann   +14 more
doaj   +1 more source

Late Stage Mannan Metabolism in Cellvibrio japonicus Requires the Combined Action of a Mannosyl‐Glucose Phosphorylase and a Mannobiose Epimerase

Molecular Microbiology, EarlyView.
Model for the non‐PTS utilization of manno‐oligosaccharides by Cellvibrio japonicus. The Mgp130A and EpiA enzymes are essential for the utilization of mannose residues. ABSTRACT Manno‐oligosaccharides and their metabolism play important roles in gut health, pharmaceutical development, and renewable chemical production.
Jessica K. Novak, Jeffrey G. Gardner
wiley   +1 more source

Macrolide-Resistant Shigella sonnei

Emerging Infectious Diseases, 2008
Shigella sonnei UCN59, isolated during an outbreak of S. sonnei in January 2007, was resistant to azithromycin (MIC 64 mg/L). The isolate contained a plasmid-borne mph(A) gene encoding a macrolide 2′-phosphotransferase that inactivates macrolides ...
Leyla Boumghar-Bourtchai, Patricia Mariani-Kurkdjian, Edouard Bingen, Ingrid Filliol, Anne Dhalluin, Shadia Ait Ifrane, François-Xavier Weill, Roland Leclercq   +7 more
doaj   +1 more source