Results 1 to 10 of about 34,333 (216)

Phosphoenolpyruvate carboxykinase in cell metabolism: Roles and mechanisms beyond gluconeogenesis [PDF]

Molecular Metabolism, 2021
Background: Phosphoenolpyruvate carboxykinase (PCK) has been almost exclusively recognized as a critical enzyme in gluconeogenesis, especially in the liver and kidney.
Shuo Yu, Simin Meng, Meixiang Xiang, Hong Ma   +3 more
doaj   +5 more sources

Identification of phosphoenolpyruvate carboxykinase 1 as a potential therapeutic target for pancreatic cancer [PDF]

Cell Death and Disease, 2021
Pancreatic cancer is the third leading cause of cancer-related mortalities and is characterized by rapid disease progression. Identification of novel therapeutic targets for this devastating disease is important. Phosphoenolpyruvate carboxykinase 1 (PCK1)
Xiao-ren Zhu, Shi-qing Peng, Le Wang, Xiao-yu Chen, Chun-xia Feng, Yuan-yuan Liu, Min-bin Chen   +6 more
doaj   +3 more sources

The requirement of phosphoenolpyruvate carboxykinase 1 for angiogenesis in vitro and in vivo. [PDF]

Sci Adv, 2022
We here examined the potential biological function of phosphoenolpyruvate carboxykinase 1 (PCK1) in angiogenesis. shRNA- or CRISPR-Cas9–induced PCK1 depletion potently inhibited endothelial cell proliferation, migration, sprouting, and tube formation ...
Yao J, Wu XY, Yu Q, Yang SF, Yuan J, Zhang ZQ, Xue JS, Jiang Q, Chen MB, Xue GH, Cao C.   +10 more
europepmc   +2 more sources

Mitochondrial phosphoenolpyruvate carboxykinase promotes tumor growth in estrogen receptor-positive breast cancer via regulation of the mTOR pathway. [PDF]

Cancer Med, 2023
Tumor cells may aberrantly express metabolic enzymes to adapt to their environment for survival and growth. Targeting cancer‐specific metabolic enzymes is a potential therapeutic strategy.
Hsu HP, Chu PY, Chang TM, Huang KW, Hung WC, Jiang SS, Lin HY, Tsai HJ.   +7 more
europepmc   +2 more sources

Neddylation of phosphoenolpyruvate carboxykinase 1 controls glucose metabolism.

Cell Metab, 2023
Summary Neddylation is a post-translational mechanism that adds a ubiquitin-like protein, namely neural precursor cell expressed developmentally downregulated protein 8 (NEDD8).
Gonzalez-Rellan MJ, Fernández U, Parracho T, Novoa E, Fondevila MF, da Silva Lima N, Ramos L, Rodríguez A, Serrano-Maciá M, Perez-Mejias G, Chantada-Vazquez P, Riobello C, Veyrat-Durebex C, Tovar S, Coppari R, Woodhoo A, Schwaninger M, Prevot V, Delgado TC, Lopez M, Diaz-Quintana A, Dieguez C, Guallar D, Frühbeck G, Diaz-Moreno I, Bravo SB, Martinez-Chantar ML, Nogueiras R.   +27 more
europepmc   +2 more sources

Expanding the clinical spectrum of cytosolic phosphoenolpyruvate carboxykinase deficiency: novel PCK1 variants in four Arabian Gulf families [PDF]

Orphanet Journal of Rare Diseases, 2023
Background In metabolic stress, the cytosolic phosphoenolpyruvate carboxykinase (PEPCK-C) enzyme is involved in energy production through the gluconeogenesis pathway.
Marwa Al Busaidi, Feda E. Mohamed, Eiman Al-Ajmi, Nadia Al Hashmi, Khalid Al-Thihli, Amna Al Futaisi, Watfa Al Mamari, Fathiya Al-Murshedi, Fatma Al-Jasmi   +8 more
doaj   +2 more sources

Nur77 suppresses hepatocellular carcinoma via switching glucose metabolism toward gluconeogenesis through attenuating phosphoenolpyruvate carboxykinase sumoylation

Nature Communications, 2017
Gluconeogenesis is downregulated in hepatocellular carcinoma. Here, the authors show that nuclear receptor Nur77 acts as a tumour suppressor sustaining gluconeogenesis by enhancing phosphoenolpyruvate carboxykinase (PEPCK1) stability via regulating its ...
Xue-li Bian, Hang-zi Chen, Peng-bo Yang, Ying-ping Li, Fen-na Zhang, Jia-yuan Zhang, Wei-jia Wang, Wen-xiu Zhao, Sheng Zhang, Qi-tao Chen, Yu Zheng, Xiao-yu Sun, Xiao-min Wang, Kun-Yi Chien, Qiao Wu   +14 more
doaj   +2 more sources

Phosphoenolpyruvate Carboxykinase Controls Edwardsiella tarda Virulence via Oxaloacetate [PDF]

Biology
Understanding the metabolic basis of bacterial virulence is essential for developing anti-infective strategies. Phosphoenolpyruvate carboxykinase (PEPCK), encoded by pckA, is a key enzyme at the metabolic junction between the pyruvate cycle and the TCA ...
Jiayao Wu, Feirong Yuan, Zilong Huang, Sihui Huang, Tianshun Kou, Xuanwei Chen, Bo Peng   +6 more
doaj   +2 more sources

Dynamic Acetylation of Phosphoenolpyruvate Carboxykinase Toggles Enzyme Activity between Gluconeogenic and Anaplerotic Reactions. [PDF]

Mol Cell, 2018
Summary Cytosolic phosphoenolpyruvate carboxykinase (PCK1) is considered a gluconeogenic enzyme; however, its metabolic functions and regulatory mechanisms beyond gluconeogenesis are poorly understood.
Latorre-Muro P, Baeza J, Armstrong EA, Hurtado-Guerrero R, Corzana F, Wu LE, Sinclair DA, López-Buesa P, Carrodeguas JA, Denu JM.   +9 more
europepmc   +2 more sources

Overexpression of Phosphoenolpyruvate Carboxykinase Increases Photosynthetic Efficiency and Salt Tolerance in Rice [PDF]

Plants
Salinity stress is one of the major obstacles to glycophytic crop production worldwide, including rice. It alters cellular metabolism, causing significant crop destruction that results in substantial reductions in yield. The overexpression of C4 enzymes,
Suchismita Prusty, Swetaleena Mishra, Sowmya Poosapati, Durga Madhab Swain, Ranjan Kumar Sahoo   +4 more
doaj   +2 more sources