Results 31 to 40 of about 41,991 (249)

Deficiency of gluconeogenic enzyme PCK1 promotes metabolic-associated fatty liver disease through PI3K/AKT/PDGF axis activation in male mice

Nature Communications, 2023
Phosphoenolpyruvate carboxykinase 1 (Pck1) is an enzyme involved in glucose production that also regulates lipogenesis and has been linked to liver steatosis.
Qian Ye, Yi Liu, Guiji Zhang, Haijun Deng, Xiaojun Wang, Lin Tuo, Chang Chen, Xuanming Pan, Kang Wu, Jiangao Fan, Qin Pan, Kai Wang, Ailong Huang, Ni Tang   +13 more
doaj   +1 more source

The promoter polymorphism -232C/G of the PCK1 gene is associated with type 2 diabetes in a UK-resident South Asian population [PDF]

, 2009
Background: The PCK1 gene, encoding cytosolic phosphoenolpyruvate carboxykinase (PEPCK-C), has previously been implicated as a candidate gene for type 2 diabetes (T2D) susceptibility.
Britten, Abigail C, Barnett Anthony H, Barnett, Anthony, Britten, Abigail C., Bellary, S, Barnett, Anthony H., Anthony H Barnett, Kumar Sudhesh, Rees, Simon D, Britten, Abigail, Sudhesh Kumar, O'Hare, J Paul, Kelly, M Ann, Rees, Simon D., Rees, Simon, Kelly, M. Ann, Kelly, Marilyn, Britten Abigail C, Kelly M Ann, Bellary, Srikanth, Rees Simon D, Srikanth Bellary, Abigail C Britten, J Paul O'Hare, Bellary Srikanth, O'Hare, JP, Kumar, Sudhesh, Barnett, Anthony H, Simon D Rees, Barnett, A. H., O'Hare J Paul, Kumar, S, O'Hare, J. Paul, M Ann Kelly   +33 more
core   +3 more sources

Structural and functional studies of phosphoenolpyruvate carboxykinase from Mycobacterium tuberculosis. [PDF]

PLoS ONE, 2015
Tuberculosis, the second leading infectious disease killer after HIV, remains a top public health priority. The causative agent of tuberculosis, Mycobacterium tuberculosis (Mtb), which can cause both acute and clinically latent infections, reprograms ...
Iva Machová, Jan Snášel, Jiří Dostál, Jiří Brynda, Jindřich Fanfrlík, Mahavir Singh, Ján Tarábek, Ondřej Vaněk, Lucie Bednárová, Iva Pichová   +9 more
doaj   +1 more source

Compensatory Increase of Serum Hepassocin Protects Hyperthyroidism-Induced Hepatic Dysfunction

Biomedicines, 2023
Hepatic dysfunction is commonly observed in subjects with hyperthyroidism. Hepassocin is a hepatokine playing an important role in metabolic diseases and exhibiting a hepatic protective effect.
Chih-Chen Wang, Ching-Han Lin, Hsuan-Wen Chou, Chung-Teng Wang, Yu-Cheng Liang, Hung-Tsung Wu, Horng-Yih Ou   +6 more
doaj   +1 more source

Crossroads between drug and energy metabolism : role of constitutive androstane receptor and AMP-activated kinase [PDF]

, 2010
Phenobarbital (PB) is a prototype inducer of genes encoding drug metabolizing enzymes including the cytochromes P450 (CYPs). Additionally, phenobarbital was found to repress genes that encode enzymes involved in gluconeogenesis such as ...
Harach, Taoufiq
core   +1 more source

Consequences of Postnatally Elevated Insulin-Like Growth Factor-II in Transgenic Mice: Endocrine Changes and Effects on Body and Organ Growth. [PDF]

, 1994
Insulin-like growth factor-II (IGF-II) is an important regulator of embryonic growth and differentiation, but its function in postnatal life is unclear. To address this point, we generated transgenic mice harboring fusion genes in which a human IGF-II
E. Wolf, Eckhard Wolf, Kramer, Rainer, Föll, Jürgen, Gottfried Brem, Brem, Gottfried, Wolf, Eckhard, Jijrgen Fijll, Blum, Werner F., Werner F. Blum, Rainer Kramer   +10 more
core   +2 more sources

Phosphoenolpyruvate carboxykinase deficiency [PDF]

Pediatric Research, 1974
Inborn errors of 3 of the 4 enzymes specific for gluconeogenesis are known. The present report describes a deficiency of the 4th enzyme phosphoenolpyruvate carboxykinase (PEP-CK). characterized by severe hypoglycemia and extreme fatty changes of liver and kidney.
F A Hommes, C Bendien, J D Elema
openaire   +1 more source

Comparison of pepck gene expression in developing seeds and leaves of chickpea (Cicer arietinum L.) plant [PDF]

Journal of Cell and Molecular Research, 2009
Phosphoenolpyruvate Carboxykinase, encoded by the pepck gene, plays an important role in gluconeogenesis. It also seems to be important in metabolism of nitrogenous compounds in developing seeds of legumes, including amides and ureides which are then ...
Ahmad Reza Bahrami, Maria Beihaghi, Abdolreza Bagheri, Richard Leegood, Mehdi Ghabooli, Jafar Zolala, Farajollah Shahriari   +6 more
doaj   +1 more source

Prognostic and immunological significance of key gluconeogenesis regulators, PCK1 and PCK2, in human cancers especially kidney renal clear cell carcinoma: Insights from pan-cancer analysis, PCKs signature construction, and in vitro experiments

Journal of Radiation Research and Applied Sciences, 2023
Background: Metabolic reprogramming is a significant feature of tumor cells, and targeting metabolic pathways has become a viable strategy for cancer therapy.
Zebin Shang, Haonan Zhao, Tianhao Yang, Xuewen Xue, Binggang Zhao, Yujie Sun   +5 more
doaj   +1 more source

Progressive, transgenerational changes in offspring phenotype and epigenotype following nutritional transition [PDF]

, 2011
Induction of altered phenotypes during development in response to environmental input involves epigenetic changes. Phenotypic traits can be passed between generations by a variety of mechanisms, including direct transmission of epigenetic states or by ...
Burdge, GC, Karen A Lillycrop, Lillycrop, KA, Samuel P Hoile, Peter D Gluckman, Karen A. Lillycrop, Graham C. Burdge, Hoile, SP, Hanson, MA, Peter D. Gluckman, Lillycrop, Karen A., Nicola A. Thomas, Hoile, Samuel P., Thomas, Nicola A., Nicola A Thomas, Gluckman, PD, Burdge, Graham C., Mark A Hanson, Graham C Burdge, Uller, T, Tobias Uller, Samuel P. Hoile, Thomas, NA, Uller, Tobias, Hanson, Mark A., Mark A. Hanson, Gluckman, Peter D.   +26 more
core   +2 more sources