Results 51 to 60 of about 41,991 (249)

Function of phosphoenolpyruvate carboxykinase in mammary gland epithelial cells[S]

Journal of Lipid Research, 2011
Previously, we have shown that Pck1 expression in mammary gland adipocytes and white adipose tissue maintains triglyceride stores through glyceroneogenesis, and these lipids were used for synthesis of milk triglycerides during lactation.
Chang-Wen Hsieh, Charles Huang, Ilya Bederman, Jianqi Yang, Michelle Beidelschies, Maria Hatzoglou, Michelle Puchowicz, Colleen M. Croniger   +7 more
doaj   +1 more source

Two Genetically Defined Tram-Acting Loci Coordinately Regulate Overlapping Sets of Liver-Specific Genes [PDF]

, 1990
Mice homozygous for deletions around the albino locus fail to activate expression of a set of neonatal liver functions and die shortly after birth. This phenotype is thought to result from the loss of a positive trans-acting factor, denoted alf, in ...
Boshart, Michael, Bosch, Franz X., Ruppert, Siegfried, Schmidt, Walter, Schlitz, Günther, Fournier, R. E. Keith   +5 more
core   +1 more source

Upregulation of cytosolic phosphoenolpyruvate carboxykinase is a critical metabolic event in melanoma cells that repopulate tumors

Cancer Research, 2015
While metabolic defects have been investigated extensively in differentiated tumor cells, much less attention has been directed to the metabolic properties of stem-like cells that repopulate tumors (tumor-repopulating cells [TRC]).
Yong Li, Shunqun Luo, R. Ma, Jing Liu, P. Xu, Hua-Feng Zhang, Ke Tang, Junwei Ma, Yi Zhang, Xiao-Yu Liang, Yanling Sun, T. Ji, Ning Wang, Bo Huang   +13 more
semanticscholar   +1 more source

Pyrosequencing primers and phosphoenolpyruvate carboxykinase CpG identifiers.

, 2013
Pyrosequencing primers and phosphoenolpyruvate carboxykinase CpG identifiers.
Graham C. Burdge (173729), Nicola A. Thomas (338568), Mark A. Hanson (114427), Samuel P. Hoile (173705), Karen A. Lillycrop (173718)   +4 more
core   +1 more source

The liver‐brain axis: A multidimensional regulatory network implicated in Alzheimer's disease pathogenesis and clinical implications

Animal Models and Experimental Medicine, EarlyView.
Schematic diagram of the core pathways of the liver‐brain axis in regulating AD. The liver regulates cerebral Aβ deposition, tau phosphorylation, and neuroinflammation through pathways such as metabolic detoxification (urea cycle, ketone body metabolism, glutathione antioxidant system), molecular secretion (APOE, CRP, FGF21, IGF‐1), and Aβ clearance ...
Ning Zhang, Wei Chen, Meng Wang
wiley   +1 more source

Optimum flux rerouting for efficient production of naringenin from acetate in engineered Escherichia coli

Biotechnology for Biofuels and Bioproducts, 2022
Background Microbial production of naringenin has received much attention owing to its pharmaceutical applicability and potential as a key molecular scaffold for various flavonoids.
Dong Hwan Kim, Hyun Gyu Hwang, Gyoo Yeol Jung   +2 more
doaj   +1 more source

Cross‐Species Single‐Cell Comparative Analysis Reveals Gluconeogenic Features of Hepatocytes in Ruminants

Animal Research and One Health, EarlyView.
In this study, we used cross‐species comparisons to identify ruminant hepatocyte features. We also identified potential genes and TFs involved in coordinating gluconeogenesis in ruminant hepatocytes. By integrating single‐cell data with population genetic analyses, we further identified candidate genetic variation in glucose metabolism and ...
Yaqi Zhou, Wuqiang Huo, Yingran Liu, Yihang Liu, Fei Wang, Tao Shi, Yu Jiang   +6 more
wiley   +1 more source

Discovery of PPi-type Phosphoenolpyruvate Carboxykinase Genes in Eukaryotes and Bacteria*

Journal of Biological Chemistry, 2015
Background: Inorganic pyrophosphate-type phosphoenolpyruvate carboxylase (PPi-PEPCK) was unidentified. Results: A conserved hypothetical protein was annotated as PPi-PEPCK.
Y. Chiba, Ryoma Kamikawa, Kumiko Nakada-Tsukui, Yumiko Saito-Nakano, T. Nozaki   +4 more
semanticscholar   +1 more source

Hypoglycemic mechanisms of Polygonatum sibiricum polysaccharide in db/db mice via regulation of glycolysis/gluconeogenesis pathway and alteration of gut microbiota

Heliyon, 2023
Polygonatum rhizoma polysaccharide (PP) is a main ingredient of Polygonatum rhizoma, which is both food and traditional herbal medicine. In this study, we aimed to investigate the hypoglycemic effect of PP and the underlying mechanisms in db/db mice. Our
Xuan Chen, Ye-ling Tong, Ze-ming Ren, Si-si Chen, Xi-yu Mei, Qing-yun Zhou, Guan-hai Dai   +6 more
doaj   +1 more source

Overexpression of PCK1 Gene Antagonizes Hepatocellular Carcinoma Through the Activation of Gluconeogenesis and Suppression of Glycolysis Pathways

Cellular Physiology and Biochemistry, 2018
Background/Aims: Gluconeogenesis, a reverse process of glycolysis, is suppressed in neoplastic livers. Cytoplasmic phosphoenolpyruvate carboxykinase (PEPCK-C/PCK1, encoded by PCK1) is a step limiting enzyme of gluconeogenesis.
Yufu Tang, Yibing Zhang, Chunhui Wang, Zhongyi Sun, Longfei Li, Shuqun Cheng, Wenping Zhou   +6 more
doaj   +1 more source