Results 1 to 10 of about 39,501 (165)

Epizootic shell disease induces systemic transcriptomic shifts in Homarus americanus, characterized by increased shell degradation and impaired energy metabolism across tissues [PDF]

Frontiers in Physiology
Epizootic shell disease (ESD) is characterized by shell erosion, pitting, and melanization in the American lobster (Homarus americanus) and is associated with a polymicrobial infection.
Minseo Kim, Dianjun Cao, Vincent Cavaleri, Kyudong Han, Kyudong Han, Kyudong Han, Seyoung Mun, Seyoung Mun, Seyoung Mun, Soo Jin Jeon   +9 more
doaj   +2 more sources

Structural mechanisms for cold-adapted activity of phosphoenolpyruvate carboxykinase. [PDF]

Protein Sci
Abstract Temperature is a critical factor in enzyme function, as most enzymes are thermally activated. Across Earth's diverse environments (−20 to 120°C), enzymes have evolved to function optimally at their organism's growth temperature. Thermophilic enzymes must resist denaturation, while psychrophilic enzymes must maintain activity with limited ...
McLeod MJ, Yazdani S, Barwell SAE, Holyoak T.   +3 more
europepmc   +2 more sources

Disruption of Mitochondrial Dynamics and Integrity Drives Divergent Metabolic Flexibility and Resilience in Podocytes. [PDF]

FASEB J
We investigated two models of mitochondrial dysfunction in podocytes, using two cell culture models: podocytes isolated from mice with Oma1 deletion (Oma1del) and mouse podocytes modified with an inducible knockdown of PHB2 (Phb2kd). OMA1 deficiency induced a glycolytic shift, enhanced glutamine anaplerosis, and sustained energy homeostasis after ...
Özel C, Reitmeier KM, Kieckhöfer E, Abualia K, Nguyen-Minh D, Matin M, Hagmann H, Coward RJM, Brähler S, Antczak P, Schermer B, Benzing T, Giavalisco P, Brinkkoetter PT.   +13 more
europepmc   +2 more sources

Biochemical characterization of phosphoenolpyruvate carboxykinases from multiple species of brown algae. [PDF]

J Phycol
Abstract Phosphoenolpyruvate carboxykinase (PEPCK) is involved in the conversion of phosphoenolpyruvate (PEP) to oxaloacetate (OAA). In addition to playing a role in gluconeogenesis in various organisms, PEPCK also functions in the C4 cycle to concentrate CO2 for photosynthesis in some C4 plants.
Jin JQ, Yokooji Y, Shibata T, Atomi H.
europepmc   +2 more sources

In Vitro Analysis of Promoter Elements Regulating Transcription of the Phosphoenolpyruvate Carboxykinase (GTP) Gene [PDF]

Molecular and Cellular Biology, 1990
A cell-free system for the study of transcription from the promoter of the phosphoenolpyruvate carboxykinase (GTP) gene by using nuclear extracts from rat tissues was developed. The level of basal transcription from the phosphoenolpyruvate carboxykinase (PEPCK) promoter between -490 and +73 was highest when extracts from liver nuclei, rather than ...
William J Roesler, Richard W. Hanson, Dwight J Klemm   +2 more
exaly   +3 more sources

Short-term actions of epigalocatechin-3-gallate in the liver: a mechanistic insight into hypoglycemic and potential toxic effects. [PDF]

FEBS Open Bio
Epigallocatechin‐3‐gallate (EGCG) acutely inhibited gluconeogenesis and enhanced glycolysis, glycogenolysis, and fatty acid oxidation in perfused rat livers. Mechanistic assays revealed mitochondrial uncoupling, inhibition of pyruvate carboxylation and glucose‐6‐phosphatase, shift of NADH/NAD+ ratios toward oxidation, and loss of membrane integrity ...
Bonetti CI, Lopes Correia B, Nakamura Manicardi FC, de Queiroz Eskuarek Melo NM, de Oliveira Pateis V, Comar JF, Babeto de Sá-Nakanishi A, Bracht A, Bracht L.   +8 more
europepmc   +2 more sources

Mechanisms and Predisposing Conditions for Statin-Induced New-Onset Type 2 Diabetes Mellitus: A Paradox Relative to Their Pleiotropic Metabolic Effects. [PDF]

Endocrinol Diabetes Metab
The primary function of statins is to inhibit cholesterol synthesis, which contributes to their antidiabetic effects. However, the majority of the diabetic effects of statins are due to inhibition of isoprenoid synthesis. Atorvastatin, simvastatin and rosuvastatin possess the most pronounced diabetogenic properties. In contrast, lovastatin, fluvastatin,
Andevari AN, Koolivand M.
europepmc   +2 more sources

The PCK2-Traf6-Tollip Axis Restricts PEDV Replication by Orchestrating Selective Autophagic Degradation of the Viral Nucleocapsid Protein. [PDF]

Transbound Emerg Dis
Porcine epidemic diarrhea virus (PEDV) is a devastating enteric pathogen in neonatal piglets, causing outbreaks with high mortality. The lack of effective vaccines or treatments makes elucidating host‐pathogen interactions essential for developing control strategies.
Gao A, Yang X, Qin W, Zheng D, Liu Y, Sun H, Chen Z, Tong G, Xue S, Kong N, Zheng L.   +10 more
europepmc   +2 more sources

The Role of the CCAAT/Enhancer-Binding Protein in the Transcriptional Regulation of the Gene for Phosphoenolpyruvate Carboxykinase (GTP) [PDF]

Molecular and Cellular Biology, 1990
Previous studies have identified a region in the promoter of the gene for phosphoenolpyruvate carboxykinase (GTP) (PEPCK) (positions -460 to +73) containing the regulatory elements which respond to cyclic AMP, glucocorticoids, and insulin and confer the tissue- and developmental stage-specific properties to the gene.
Jon D Shuman, William J Roesler, Alan D Friedman   +2 more
exaly   +3 more sources

Overexpression of the cytosolic form of phosphoenolpyruvate carboxykinase (GTP) in skeletal muscle repatterns energy metabolism in the mouse. [PDF]

J Biol Chem, 2007
Transgenic mice, containing a chimeric gene in which the cDNA for phosphoenolpyruvate carboxykinase (GTP) (PEPCK-C) (EC 4.1.1.32) was linked to the alpha-skeletal actin gene promoter, express PEPCK-C in skeletal muscle (1-3 units/g). Breeding two founder lines together produced mice with an activity of PEPCK-C of 9 units/g of muscle (PEPCK-C(mus) mice).
Hakimi P, Yang J, Casadesus G, Massillon D, Tolentino-Silva F, Nye CK, Cabrera ME, Hagen DR, Utter CB, Baghdy Y, Johnson DH, Wilson DL, Kirwan JP, Kalhan SC, Hanson RW.   +14 more
europepmc   +4 more sources