Results 21 to 30 of about 39,501 (165)

A GTP-dependent Vertebrate-type Phosphoenolpyruvate Carboxykinase from Mycobacterium smegmatis [PDF]

Journal of Biological Chemistry, 2001
This is the first report on a bacterial verterbrate-type GTP-dependent phosphoenolpyruvate carboxykinase (PCK). The pck gene of Mycobacterium smegmatis was cloned. The recombinant PCK was overexpressed in Escherichia coli in a soluble form and with high activity. The purified enzyme was found to be monomeric (72 kDa), thermophilic (optimum temperature,
B, Mukhopadhyay, E M, Concar, R S, Wolfe
openaire   +2 more sources

Phosphoenolpyruvate Cycling via Mitochondrial Phosphoenolpyruvate Carboxykinase Links Anaplerosis and Mitochondrial GTP with Insulin Secretion [PDF]

Journal of Biological Chemistry, 2009
Pancreatic beta-cells couple the oxidation of glucose to the secretion of insulin. Apart from the canonical K(ATP)-dependent glucose-stimulated insulin secretion (GSIS), there are important K(ATP)-independent mechanisms involving both anaplerosis and mitochondrial GTP (mtGTP).
Stark, Romana, Pasquel, Francisco, Turcu, Adina, Pongratz, Rebecca L., Roden, Michael, Cline, Gary W., Shulman, Gerald I., Kibbey, Richard G.   +7 more
openaire   +2 more sources

Glucocorticoid exposure in late gestation permanently programs rat hepatic phosphoenolpyruvate carboxykinase and glucocorticoid receptor expression and causes glucose intolerance in adult offspring [PDF]

, 1998
Low birth weight in humans is predictive of insulin resistance and diabetes in adult life. The molecular mechanisms underlying this link are unknown but fetal exposure to excess glucocorticoids has been implicated, The fetus is normally protected from ...
Kenyon, C J, Seckl, J R, C J Kenyon, Burchell, A, R S Lindsay, A Burchell, J R Seckl, Lindsay, R S, M J Nyirenda, Nyirenda, M J   +9 more
core   +1 more source

Crossroads between drug and energy metabolism : role of constitutive androstane receptor and AMP-activated kinase [PDF]

, 2010
Phenobarbital (PB) is a prototype inducer of genes encoding drug metabolizing enzymes including the cytochromes P450 (CYPs). Additionally, phenobarbital was found to repress genes that encode enzymes involved in gluconeogenesis such as ...
Harach, Taoufiq
core   +1 more source

The promoter polymorphism -232C/G of the PCK1 gene is associated with type 2 diabetes in a UK-resident South Asian population [PDF]

, 2009
Background: The PCK1 gene, encoding cytosolic phosphoenolpyruvate carboxykinase (PEPCK-C), has previously been implicated as a candidate gene for type 2 diabetes (T2D) susceptibility.
Britten, Abigail C, Barnett Anthony H, Barnett, Anthony, Britten, Abigail C., Bellary, S, Barnett, Anthony H., Anthony H Barnett, Kumar Sudhesh, Rees, Simon D, Britten, Abigail, Sudhesh Kumar, O'Hare, J Paul, Kelly, M Ann, Rees, Simon D., Rees, Simon, Kelly, M. Ann, Kelly, Marilyn, Britten Abigail C, Kelly M Ann, Bellary, Srikanth, Rees Simon D, Srikanth Bellary, Abigail C Britten, J Paul O'Hare, Bellary Srikanth, O'Hare, JP, Kumar, Sudhesh, Barnett, Anthony H, Simon D Rees, Barnett, A. H., O'Hare J Paul, Kumar, S, O'Hare, J. Paul, M Ann Kelly   +33 more
core   +3 more sources

Illegitimate recombination: An efficient method for random mutagenesis in Mycobacterium avium subsp. hominissuis

BMC Microbiology, 2012
Background The genus Mycobacterium (M.) comprises highly pathogenic bacteria such as M. tuberculosis as well as environmental opportunistic bacteria called non-tuberculous mycobacteria (NTM).
Khattak Faisal, Kumar Ashutosh, Kamal Elisabeth, Kunisch Ralph, Lewin Astrid   +4 more
doaj   +1 more source

Progressive, transgenerational changes in offspring phenotype and epigenotype following nutritional transition [PDF]

, 2011
Induction of altered phenotypes during development in response to environmental input involves epigenetic changes. Phenotypic traits can be passed between generations by a variety of mechanisms, including direct transmission of epigenetic states or by ...
Burdge, GC, Karen A Lillycrop, Lillycrop, KA, Samuel P Hoile, Peter D Gluckman, Karen A. Lillycrop, Graham C. Burdge, Hoile, SP, Hanson, MA, Peter D. Gluckman, Lillycrop, Karen A., Nicola A. Thomas, Hoile, Samuel P., Thomas, Nicola A., Nicola A Thomas, Gluckman, PD, Burdge, Graham C., Mark A Hanson, Graham C Burdge, Uller, T, Tobias Uller, Samuel P. Hoile, Thomas, NA, Uller, Tobias, Hanson, Mark A., Mark A. Hanson, Gluckman, Peter D.   +26 more
core   +2 more sources

Consequences of Postnatally Elevated Insulin-Like Growth Factor-II in Transgenic Mice: Endocrine Changes and Effects on Body and Organ Growth. [PDF]

, 1994
Insulin-like growth factor-II (IGF-II) is an important regulator of embryonic growth and differentiation, but its function in postnatal life is unclear. To address this point, we generated transgenic mice harboring fusion genes in which a human IGF-II
E. Wolf, Eckhard Wolf, Kramer, Rainer, Föll, Jürgen, Gottfried Brem, Brem, Gottfried, Wolf, Eckhard, Jijrgen Fijll, Blum, Werner F., Werner F. Blum, Rainer Kramer   +10 more
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Phosphoenolpyruvate carboxykinase and the critical role of cataplerosis in the control of hepatic metabolism

Nutrition & Metabolism, 2005
Background The metabolic function of PEPCK-C is not fully understood; deletion of the gene for the enzyme in mice provides an opportunity to fully assess its function. Methods The gene for the cytosolic form of phosphoenolpyruvate carboxykinase (GTP) (EC
Kalhan Satish C, Conlon Ronald A, Lepage David F, Yang Jianqi, Johnson Mark T, Hakimi Parvin, Reshef Lea, Tilghman Shirley M, Hanson Richard W   +8 more
doaj   +1 more source

Two Genetically Defined Tram-Acting Loci Coordinately Regulate Overlapping Sets of Liver-Specific Genes [PDF]

, 1990
Mice homozygous for deletions around the albino locus fail to activate expression of a set of neonatal liver functions and die shortly after birth. This phenotype is thought to result from the loss of a positive trans-acting factor, denoted alf, in ...
Boshart, Michael, Bosch, Franz X., Ruppert, Siegfried, Schmidt, Walter, Schlitz, Günther, Fournier, R. E. Keith   +5 more
core   +1 more source