Results 31 to 40 of about 39,501 (165)

Identification of vicinal thiols of phosphoenolpyruvate carboxykinase (GTP).

Journal of Biological Chemistry, 1993
Phosphoenolpyruvate carboxykinase (PEPCK) from the cytosol of rat liver has 13 cysteines, at least one of which (Cys288) is known to be very reactive and critical for catalytic activity (Lewis, C. T., Seyer, J. M., and Carlson, G. M. (1989) J. Biol. Chem. 264, 27-33).
C T, Lewis, J M, Seyer, R G, Cassell, G M, Carlson   +3 more
openaire   +2 more sources

Mn2+-sensitive and -insensitive forms of phosphoenolpyruvate carboxykinase (GTP).

Journal of Biological Chemistry, 1981
Phosphoenolpyruvate carboxykinase (GTP) (EC 4.1.1.32) from rat liver cytosol is activated by micromolar concentrations of Mn2+ under conditions where GTP is present as the MgGTP complex and free Mg2+ is present in excess. The purified, homogeneous enzyme rapidly loses the ability to be activated by Mn2+ upon storage, incubation with oxidized ...
R I, Brinkworth, R W, Hanson, F A, Fullin, V L, Schramm   +3 more
openaire   +2 more sources

Regulation of phosphoenolpyruvate carboxykinase (GTP) in adipose tissue in vivo by glucocorticoids and insulin [PDF]

Biochemical Journal, 1976
1. The regulation of the synthesis of phosphoenolpyruvate carboxykinase (GTP) (EC 4.1.1.32) in epididymal adipose tissue, liver and kidney in vivo was studied immunochemically. 2. Phosphoenolpyruvate carboxykinase (GTP) synthesis in adipose tissue is increased by starvation, diabetes and noradrenaline, and decreased by re-feeding and insulin.
O, Meyuhas, L, Reshef, J M, Gunn, R W, Hanson, F J, Ballard   +4 more
openaire   +2 more sources

Cysteine 288: An essential hyperreactive thiol of cytosolic phosphoenolpyruvate carboxykinase (GTP)

Journal of Biological Chemistry, 1989
Phosphoenolpyruvate carboxykinase from the cytosol of rat liver has 13 cysteines, at least one of which is known to be very reactive and essential for catalytic activity (Carlson, G. M., Colombo, G., and Lardy, H. A. (1978) Biochemistry 17, 5329-5338). In order to identify the essential cysteine, this enzyme was modified with the fluorescent sulfhydryl
C T, Lewis, J M, Seyer, G M, Carlson
openaire   +2 more sources

Promoter Polymorphism in PCK1 (Phosphoenolpyruvate Carboxykinase Gene) Associated with Type 2 Diabetes Mellitus [PDF]

, 2004
"We sequenced the promoter and coding regions of PCK1 encoding cytosolic phosphoenolpyruvate carboxykinase from genomic DNA of subjects with type 2 diabetes mellitus (DM).
Hanley, Anthony J.G., Harris, S. B., Hegele, Robert A., Young, T. Kue, van der Veer, Eric, Ban, Matthew R., Zinman, Bernard, Pickering, J. Geoffrey, Cao, Henian   +8 more
core   +1 more source

Effect of hyperosmotic shock on phosphoenolpyruvate carboxykinase gene expression and gluconeogenic activity in the crab muscle [PDF]

, 2004
Chasmagnathus granulata phosphoenolpyruvate carboxykinase (PEPCK) cDNA from jaw muscle was cloned and sequenced, showing a specific domain to bind phosphoenolpyruvate in addition to the kinase-1 and kinase-2 motifs to bind guanosine triphosphate (GTP ...
Schein, Vanessa, Da Silva, Roselis S.M, Luiz Carlos Kucharski, Vanessa Schein, Yann Waché, Kucharski, Luiz Carlos, Rodrigo Etges, Alain van Wormhoudt, van Wormhoudt, Alain, Roselis S.M Da Silva, Etges, Rodrigo, Waché, Yann   +11 more
core   +1 more source

Is the p29 protein involved in the rapid regulation of phosphoenolpyruvate carboxykinase (GTP)?

Journal of Biological Chemistry, 1991
It has been postulated that a protein with a molecular mass of 29,000 daltons (p29), which copurifies with hepatic phosphoenolpyruvate (P-enolpyruvate) carboxykinase, forms a complex with the enzyme and stabilizes its sensitivity to Mn2+ activation by protecting critical sulfhydryl groups from oxidation (Brinkworth, R. I., Hanson, R. W., Fullin, F. A.,
W, Höppner, L, Beckert, F, Buck, H J, Seitz   +3 more
openaire   +2 more sources

Alteration of de novo glucose production contributes to fasting hypoglycaemia in fyn deficient mice [PDF]

, 2013
Previous studies have demonstrated that glucose disposal is increased in the Fyn knockout (FynKO) mice due to increased insulin sensitivity. FynKO mice also display fasting hypoglycaemia despite decreased insulin levels, which suggested that hepatic ...
Bastie, Claire C., Kurland, Irwin J., Elena Tarabra, Gustavo Palacios, Jeffrey E Pessin, Yang Yingjuan, Bastie Claire C., Tarabra, Elena, Gong-She Yang (490794), Claire C. Bastie (187271), Palacios Gustavo, Yingjuan Yang (490792), Irwin J. Kurland (177409), Claire C Bastie, Yingjuan Yang, Yang Gong-She, Yang, Gong-She, Irwin J Kurland, Vaitheesvaran, Bhavapriya, Palacios, Gustavo, Pessin Jeffrey E., Jeffrey E. Pessin (187274), Vaitheesvaran Bhavapriya, Yang, Yingjuan, Bhavapriya Vaitheesvaran (177385), Elena Tarabra (490793), Tarabra Elena, Bhavapriya Vaitheesvaran, Gustavo Palacios (67191), Kurland Irwin J., Gong-She Yang, Pessin, Jeffrey E.   +31 more
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Glutamine Metabolism in Health and Diseases

MedComm, Volume 7, Issue 10, October 2026.
Glutamine metabolism acts as a metabolic hub connecting cellular stress adaptation, immune regulation, and disease development. Through regulating energy production, biosynthesis, redox balance, and nitrogen metabolism, glutamine supports cellular homeostasis under physiological and pathological conditions.
Yi Ding, Fan Tong, Jing Zeng, Chun‐Ping Cui   +3 more
wiley   +1 more source

Vanadate inhibits expression of the gene for phosphoenolpyruvate carboxykinase (GTP) in rat hepatoma cells.

Journal of Biological Chemistry, 1990
Vanadate, at concentrations between 0.5 and 2 mM, rapidly decreased the basal level of P-enolpyruvate carboxykinase (GTP) (EC 4.1.1.32) mRNA and blocked the dibutyryl cyclic AMP (Bt2cAMP)-induced increase in enzyme mRNA in both FTO-2B and H4IIE rat hepatoma cells.
Bosch i Tubert, Fàtima, Hatzoglou, Maria, Park, Edwards A., Hanson, Richard W.   +3 more
openaire   +3 more sources