Results 61 to 70 of about 41,991 (249)

Human biomarker navigator

iMeta, EarlyView.
The Human Biomarker Navigator integrates the disease continuum, biomarker dynamics, cross‐organ biomarker networks, biomarker classification, and technology‐driven paradigms. It maps how biomarkers link multi‐system physiology and pathology across the nervous, respiratory, endocrine, circulatory, immune, digestive, urinary, reproductive, and ...
Meng‐Yao Li, Qian Zhang, Zijie Wang, Zeping Gui, Jing Liu, Jingda Li, Maojun Jiang, Zukang Chang, Qingqing Han, Bendong Yang, Tariq Saeed, Jun Li, Jinghan Jia, Chenghu Song, Tong Shao, Tianhuan Peng, Xueying Zhang, Pingping Guo, Jun Luo, Gangao Yang, Yuan Wan, Gokhan Zengin, Quan Yuan, Lingru Li, Xiaohui Fan, Yang Luo, Lvyun Zhu, Yanfei Zheng, Wenjun Mao, Wenlong Sun   +29 more
wiley   +1 more source

Mitochondrial Phosphoenolpyruvate Carboxykinase (PEPCK-M) Is a Pro-survival, Endoplasmic Reticulum (ER) Stress Response Gene Involved in Tumor Cell Adaptation to Nutrient Availability*

Journal of Biological Chemistry, 2014
Background: The integrated stress response (ISR) is necessary to help the tumor adapt to its microenvironment. Results: ATF4 activates a PEPCK-M-dependent pro-survival pathway under amino acid deprivation or ER stress (ISR) by binding to its proximal ...
Andrés Méndez-Lucas, P. Hyroššová, L. Novellasdemunt, F. Viñals, J. C. Perales   +4 more
semanticscholar   +1 more source

Functional Characterization of Serum-Free Cultured Rat Hepatocytes for Downstream Transplantation Applications

Cell Transplantation, 2005
Although ex vivo culture of hepatocytes is known to impair functionality, it may still be considered as desirable to propagate or manipulate them in culture prior to transplantation into the host liver.
Hendryk Aurich, Sarah Koenig, Christian Schneider, Jens Walldorf, Petra Krause, Wolfgang E. Fleig, Bruno Christ   +6 more
doaj   +1 more source

Ontogenic Profile of Gluconeogenic Key Enzyme Gene Expressions in Embryonic Chicken Liver and Muscle

The Journal of Poultry Science, 2013
To elucidate biochemical mechanisms underlining high plasma glucose in chicken embryo, gene expression profile of gluconeogenic key enzymes were characterized.
Tushar K. Roy, Atsushi Iwasawa, Yasutake Shimizu, Koji Kageyama, Norio Yoshizaki   +4 more
doaj   +1 more source

Aspects of the Control of Phosphoenolpyruvate Carboxykinase Gene Transcription [PDF]

Journal of Biological Chemistry, 2009
Abstract This article reviews our current understanding of factors that regulate transcription of the gene for PEPCK-C, focusing on the effect of methylation on gene expression. It also provides insight into the evolutionary status of the PEPCK-C gene.
Jianqi, Yang, Lea, Reshef, Hanoch, Cassuto, Gabriela, Aleman, Richard W, Hanson   +4 more
openaire   +2 more sources

Regulating Lipid Metabolism in Cancer: The Therapeutic Potential of Traditional Chinese Medicine

Phytotherapy Research, EarlyView.
By regulating the reprogramming of lipid metabolism in tumor cells, TCM provides a novel strategy for antitumor therapy with reduced toxicity and enhanced efficacy. ABSTRACT Lipid metabolic reprogramming is a key feature of tumor cells to adapt to the microenvironment and plays an important role in tumor growth, invasion, and metastasis.
Yufeng Gao, Huiming Huang, Xuejiao Wei, Xiaoxue Wang, Wanying Xie, Xinyu Qiu, Fei Wang, Zhuguo Wang, Ruoxin Zhang, Yilin Cai, Changhai Qu, Zhongdong Hu   +11 more
wiley   +1 more source

Mycobacterium tuberculosis Phosphoenolpyruvate Carboxykinase Is Regulated by Redox Mechanisms and Interaction with Thioredoxin*

Journal of Biological Chemistry, 2014
Background: Phosphoenolpyruvate carboxykinase (Pck) catalyzes the interconversion of phosphoenolpyruvate and oxaloacetate but typically prefers gluconeogenic formation of phosphoenolpyruvate.
I. Machová, J. Snášel, Michael Zimmermann, D. Laubitz, P. Płociński, W. Oehlmann, Mahavir Singh, J. Dostál, U. Sauer, I. Pichová   +9 more
semanticscholar   +1 more source

Phosphoenolpyruvate carboxykinase in Phycomyces blakesleeanus Bgff.

, 2014
Phosphoenolpyruvate carboxykinase (PEPCK) from Phycomyces blakesleeanus was partially purified by protamine sulfate precipitation, ammoniumsulfate precipitation, and diethylamino ethyl cellulose (DEAE) treatment.
Sandmann, Gerhard, Hilgenberg, Wilhelm
core   +1 more source

Application of a Novel and Automated Branched DNA in Situ Hybridization Method for the Rapid and Sensitive Localization of mRNA Molecules in Plant Tissues

Applications in Plant Sciences, 2014
Premise of the study: A novel branched DNA detection technology, RNAscope in situ hybridization (ISH), originally developed for use on human clinical and animal tissues, was adapted for use in plant tissue in an attempt to overcome some of the ...
Andrew J. Bowling, Heather E. Pence, Jeffrey B. Church   +2 more
doaj   +1 more source

Mycobacterium intracellulare M.i.198—A Promising Strain for Studying Pathogenesis of Nontuberculous Mycobacterial Pulmonary Disease (NTM‐PD)

Microbiology and Immunology, EarlyView.
ABSTRACT In this review, we introduce a promising strain for studying pathogenesis of nontuberculous mycobacterial pulmonary disease (NTM‐PD), Mycobacterium intracellulare M.i.198. M.i.198 was isolated from a patient with progressive Mycobacterium avium‐intracellulare complex pulmonary disease (MAC‐PD) in whom surgical operation was required to ...
Yoshitaka Tateishi, Ryoji Maekura, Yukiko Nishiuchi, Sohkichi Matsumoto   +3 more
wiley   +1 more source