Results 21 to 30 of about 41,991 (249)
Biological Research, 2010 The functional signifcance of tyrosine 207 of Saccharomyces cerevisiae phosphoenolpyruvate carboxykinase was explored by examining the kinetic properties of the Tyr207Leu mutant. The variant enzyme retained the structural characteristics of the wild-type
Cherie Andrade +3 more
doaj +2 more sources
Journal of Education, Health and Sport, 2023 Existing types of muscles differ not only structurally, but also metabolically (direction of energy exchange, choice of biosubstrates, dependence on the action of mediators, hormones, etc.).
G. Stepanov +3 more
doaj +1 more source
The NADPH oxidase NOX4 regulates redox and metabolic homeostasis preventing HCC progression
Hepatology, EarlyView., 2022 Loss of NOX4 in HCC tumor cells induces metabolic reprogramming in a Nrf2/MYC‐dependent manner to promote HCC progression. Abstract Background and Aims The NADPH oxidase NOX4 plays a tumor‐suppressor function in HCC. Silencing NOX4 confers higher proliferative and migratory capacity to HCC cells and increases their in vivo tumorigenic potential in ...
Irene Peñuelas‐Haro +14 more
wiley +1 more source
The possible role of Phosphoenolpyrovate Carboxykinase (PEPCKin protein content of chickpea seeds (Cicer arietinum L [PDF]
پژوهشهای حبوبات ایران, 2010 Phosphoenolpyruvate Carboxykinase (PEPCK) has been shown to be present in plants andanimals, playing different metabolic roles in different tissues. The basic role of this enzyme is itscontribution in the gluconeogenesis pathway.
Maria Beihaghi +4 more
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Genetic variability in exon 9 of PEPCK-M gene in different strains of chickens using PCR-RFLP method [PDF]
مجله بیوتکنولوژی کشاورزی, 2015 Phosphoenolpyruvate carboxykinase (PEPCK) catalyzes the first step of the gluconeogenesis cycle. There are two isozymes forms of this enzyme, cytosolic phosphoenolpyruvate carboxykinase (PEPCK-C) and mitochondrial phosphoenolpyruvate carboxykinase (PEPCK-
Zohreh Yousefi +2 more
doaj +1 more source
O-GlcNAcylated p53 in the liver modulates hepatic glucose production
Nature Communications, 2021 p53 regulates signalling pathways involved in metabolic homeostasis. Here the authors show that O-GlcNAcylation of p53 in the liver plays a key role in the physiological regulation of glucose homeostasis, potentially via controlling the expression of the
Maria J. Gonzalez-Rellan +42 more
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IUCrJ, 2021 Time-resolved crystallography of biomolecules in action has advanced rapidly as methods for serial crystallography have improved, but the large number of crystals and the complex experimental infrastructure that are required remain serious obstacles to ...
Jonathan A. Clinger +4 more
doaj +1 more source
Regulation of gluconeogenesis in type 2 diabetes mellitus: An investigation of the role of corticosteroids? [PDF]
, 2012 PhDType 2 diabetes mellitus (T2DM) is a complex disease involving various physiological factors, hormones and metabolites. Over expression of key gluconeogenic enzymes, such as PEPCK, cause features of T2DM including obesity and insulin resistance ...
Nayuni, Nanda Kishore Babu
core +4 more sources
Glucocorticoid exposure in late gestation permanently programs rat hepatic phosphoenolpyruvate carboxykinase and glucocorticoid receptor expression and causes glucose intolerance in adult offspring [PDF]
, 1998 Low birth weight in humans is predictive of insulin resistance and diabetes in adult life. The molecular mechanisms underlying this link are unknown but fetal exposure to excess glucocorticoids has been implicated, The fetus is normally protected from ...
Kenyon, C J +9 more
core +1 more source
Dibenzylxanthines as PPEPCK-M Inhibitors for Cancer Therapy
Proceedings, 2019 Phosphoenolpyruvate carboxykinase (PEPCK) is the key enzyme in gluconeogenesis/glyceroneogenesis, which catalyzes the decarboxylation of oxaloacetate to phosphoenolpyruvate. [...]
Marc Aragó +9 more
doaj +1 more source