Biological Evaluation of a Mitochondrial Phosphoenolpyruvate Carboxykinase Inhibitor
Proceedings, 2019 Phosphoenolpyruvate carboxykinase (PEPCK) is a key enzyme in gluconeogenesis, catalyzingthe decarboxylation of oxaloacetate to phosphoenolpyruvate. [...]
Sergio Rodríguez-Arévalo +9 more
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Effects of heterologous expression of phosphoenolpyruvate carboxykinase and phosphoenolpyruvate carboxylase on organic acid production in Aspergillus carbonarius [PDF]
Journal of Industrial Microbiology & Biotechnology, 2015 Aspergillus carbonarius has a potential as a cell factory for production of various organic acids. In this study, the organic acid profile of A. carbonarius was investigated under different cultivation conditions.
Lei Yang, M. Lübeck, P. Lübeck
semanticscholar +2 more sources
Expression and functional significance of phosphoenolpyruvate carboxykinase 1 in uveal melanoma [PDF]
Cell Death DiscoveryUveal melanoma (UVM), an uncommon yet potentially life-threatening ocular cancer, arises from melanocytes in the uveal tract of the eye. The exploration of novel oncotargets for UVM is of paramount importance.
Hui-e Bi +6 more
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Cytosolic phosphoenolpyruvate carboxykinase as a cataplerotic pathway in the small intestine.
Am J Physiol Gastrointest Liver Physiol, 2018 Cytosolic phosphoenolpyruvate carboxykinase (PEPCK) is a gluconeogenic enzyme that is highly expressed in the liver and kidney but is also expressed at lower levels in a variety of other tissues where it may play adjunct roles in fatty acid ...
Potts A +9 more
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Succinate Dehydrogenase-Regulated Phosphoenolpyruvate Carboxykinase Sustains Copulation Fitness in Aging C. elegans Males [PDF]
iScience, 2020 Summary: Dysregulated metabolism accelerates reduced decision-making and locomotor ability during aging. To identify mechanisms for delaying behavioral decline, we investigated how C.
Jimmy Goncalves +7 more
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What Is the Metabolic Role of Phosphoenolpyruvate Carboxykinase? [PDF]
Journal of Biological Chemistry, 2009 The enzyme phosphoenolpyruvate carboxykinase (GTP; EC 4.1.1.32) (PEPCK)2 has the unusual distinction of being very well studied but metabolically misunderstood. As we will document in this minireview, the enzyme has been almost exclusively linked to gluconeogenesis to the point that changes in the levels of PEPCK mRNA or its activity are associated ...
Jianqi, Yang +2 more
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Kinetic and functional properties of human mitochondrial phosphoenolpyruvate carboxykinase [PDF]
Biochemistry and Biophysics Reports, 2016 The cytosolic form of phosphoenolpyruvate carboxykinase (PCK1) plays a regulatory role in gluconeogenesis and glyceroneogenesis. The role of the mitochondrial isoform (PCK2) remains unclear.
M. Escós +5 more
semanticscholar +2 more sources
Phosphoenolpyruvate carboxykinases as emerging targets in cancer therapy
Frontiers in Cell and Developmental Biology, 2023 Metabolic reprogramming is commonly accompanied by alterations in the expression of metabolic enzymes. These metabolic enzymes not only catalyze the intracellular metabolic reaction, but also participate in a series of molecular events to regulate tumor ...
Yong Yu, Jingying Li, Kaiming Ren
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Association of mitochondrial phosphoenolpyruvate carboxykinase with prognosis and immune regulation in hepatocellular carcinoma [PDF]
Scientific ReportsMitochondrial phosphoenolpyruvate carboxykinase (PCK2), a mitochondrial isoenzyme, supports the growth of cancer cells under glucose deficiency conditions in vitro.
Chenxuan Li +5 more
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Characterization of interaction and ubiquitination of phosphoenolpyruvate carboxykinase by E3 ligase UBR5 [PDF]
Biology Open, 2018 Phosphoenolpyruvate carboxykinase (PEPCK1) is ubiquitinated by E3 ubiquitin ligase UBR5, which was thought to be facilitated by the acetylation of Lys70, Lys71 and Lys594 in PEPCK1.
Qingya Shen +4 more
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