Results 31 to 40 of about 3,969 (139)
Measuring catalytic mechanism similarity – a new approach to study enzyme function and evolution
We introduce a previously undescribed computational method to measure the similarity of enzyme mechanisms, enabling comparison of catalytic steps across hundreds of enzymes. Applying this method to a database of enzyme mechanisms demonstrated its ability to automatically uncover functional and evolutionary relationships, independently of sequence and ...
Antonio J. M. Ribeiro+5 more
wiley +1 more source
Modification Of 4,5- Aminoglycosides To Overcome Drug Resistance Bacteria And Toxic Side Effect [PDF]
MODIFICATION OF 4,5- AMINOGLYCOSIDES TO OVERCOME DRUG RESISTANCE BACTERIA AND TOXIC SIDE EFFECT by Guanyu Yang September 2018 Advisor: Professor David Crich Major: Chemistry Degree: Doctor of Philosophy Infectious diseases causing by antibiotic resistant
Yang, Guanyu
core +1 more source
Structural and Functional Investigation of Bacterial Membrane Biosynthesis [PDF]
Integral membrane enzymes contribute a unique repertoire to the cell, as they are capable of synthesizing products from substrates of different chemical character at the membrane-water interface.
Belcher Dufrisne, Meagan Leigh
core +2 more sources
Complete structure of the enterococcal polysaccharide antigen (EPA) of vancomycin-resistant enterococcus faecalis V583 reveals that EPA decorations are teichoic acids covalently linked to a rhamnopolysaccharide backbone [PDF]
All enterococci produce a complex polysaccharide called the enterococcal polysaccharide antigen (EPA). This polymer is required for normal cell growth and division and for resistance to cephalosporins and plays a critical role in host-pathogen ...
Ainsworth+64 more
core +2 more sources
APPLICATION OF NANOSTRUCTURES IN ANTIMICROBIAL THERAPY [PDF]
There are many infectious diseases that may be biofilm mediated, medical device-mediated or from some other agent, are now becoming life-threatening. Despite of availability of many antimicrobial agents, new drugs or therapeutics, these infections have ...
Mahavir, Joshi+3 more
core +3 more sources
Traditional Chinese Medicine (TCM), while holistic and historically esteemed, faces challenges in “miracle cures” due to slow onset, long cycles, and difficulty controlling quality. This study obtains the active ingredients, glabridin (GLA) and puerarin (PUE), from Ge‐Gen Decoction (GGD), developing a safe and effective drug delivery system, GLA‐PUE ...
Jianhong Qi+7 more
wiley +1 more source
MOZART, a QSAR Multi-Target Web-Based Tool to Predict Multiple Drug–Enzyme Interactions [PDF]
Developing models able to predict interactions between drugs and enzymes is a primary goal in computational biology since these models may be used for predicting both new active drugs and the interactions between known drugs on untested targets. With the
Concu, Riccardo+3 more
core +1 more source
Structures of alternatively spliced isoforms of human ketohexokinase [PDF]
The structures of the two alternatively spliced isoforms of human ketohexokinase, hepatic KHK-C and peripheral KHK-A, and of the ternary complex of KHK-A with the substrate fructose and AMP-PNP have been solved.
Asipu, Aruna+3 more
core +2 more sources
Predicting the mechanisms of polysaccharides against gastric ulcer. Abstract Gastric ulcer is a common peptic ulcer that affects human health and life quality seriously. As anti‐gastric ulcer drugs usually cause side‐effects, polysaccharides may be the potential alternatives because of better effectiveness and less toxicity.
Jia‐Yu Huang+9 more
wiley +1 more source
This study reveals the regulatory mechanism behind sugar metabolism and dextran synthesis by Leuconostoc pseudomesenteroides DSM20193 during the fermentation of a complex substrate like brewers spent grain. Understanding metabolic pathways and genetic adaptation of lactic acid bacteria in food environments can help develop fermented products with ...
Koirala Prabin+3 more
wiley +1 more source