Synthesis Of Apramycin And Paromomycin Derivatives As Potential Next Generation Aminoglycoside Antibiotics And Chemistry Of Isothiocyanato Sialyl Donors [PDF]
AGAs are clinically important antibacterials for human therapy and have long been used as highly potent antibiotics for treating several bacterial infections.
Mandhapati, Appi Reddy
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Abstract Multiple sensorial, technological, and nutritional challenges must be overcome when developing plant‐based fermented dairy alternatives (PBFDA) to mimic their dairy counterparts. The elimination of plant‐derived off‐flavors (green, earthy, bitter, astringent) and the degradation of antinutrients are crucial quality factors highlighted by the ...
Guillermo Eduardo Sedó Molina+5 more
wiley +1 more source
Structural and functional characterization of the aminoacetone utilization microcompartment from Mycobacterium smegmatis MC2 155 [PDF]
Bacterial microcompartments are proteinacious complexes made by bacteria, which metabolize volatile or cytotoxic chemicals, by sequestering a series of reactions within a selectively permeable shell.
Mallette, Evan
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Metagenomic analysis of three thermophilic species was performed to identify key species for stable biogas production at high free ammonia levels (> 0.7 g/L). Potential acetogens and syntrophic acetate‐oxidising bacteria (SAOB) were recovered by looking for genes of the Wood–Ljungdahl pathway and glycine synthase reductase pathway.
George B. Cheng+2 more
wiley +1 more source
Structure and mechanism of the RNA polymerase II CTD phosphatase Scp1 and large-scale preparation of the RNA polymerase II-TFIIF complex [PDF]
TFIIF is the only general transcription factor that has been implicated in the preinitiation complex assembly, open complex formation, initiation and transcription elongation. In addition, TFIIF stimulates Fcp1, a central phosphatase needed for recycling
Kamenski, Tomislav
core
The Mysterious World of Non‐Canonical Caps – What We Know and Why We Need New Sequencing Techniques
This review describes sophisticated methodologies such as LC–MS that enabled the identification of 5’ non‐canonical RNA caps and also surveys so far developed sequencing methods, evaluating their advantages and disadvantages. It emphasizes the need for developing new, reliable sequencing techniques to identify RNA types with non‐canonical caps enabling
Flaminia Mancini, Hana Cahova
wiley +1 more source
HMGA1 drives stem cell, inflammatory pathway, and cell cycle progression genes during lymphoid tumorigenesis [PDF]
Background Although the high mobility group A1 (HMGA1) gene is widely overexpressed in diverse cancers and portends a poor prognosis in some tumors, the molecular mechanisms that mediate its role in transformation have remained elusive.
A Belton+88 more
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Paradigms of convergent evolution in enzymes
Some enzymes are able to catalyse the same reaction despite possessing different structures. Here, we used a combined strategy of analysing published literature and knowledge‐based computational resources to explore this. We conclude that multiple varieties of convergent functional evolution exist to date, but that it is necessary to investigate ...
Ioannis G. Riziotis+5 more
wiley +1 more source
Application of computer-based methods to design inhibitors of zinc-dependent enzymes [PDF]
Die vorliegende Arbeit veranschaulicht die Anwendung von Computergestütztes Wirkstoffdesign im Kontext der Entwicklung von Enzyminhibitoren. Sie berichtet, wie neuartige Hits für das antiparasitäre Target (SmHDAC8) mithilfe von virtuellem Screening ...
Melesina, Jelena
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Acetate Metabolism: The physiological role of ADP-forming acetyl-CoA synthetase and acetate kinase in Entamoeba histolytica [PDF]
Entamoeba histolytica is a protozoan parasite that causes amoebic colitis and liver abscess in approximately 90 million people each year, resulting in 50,000-100,000 fatalities.
Dang, Thanh
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