Repurposing Old Drugs: Substituted Benzodiazepines as New Antibacterial Agents [PDF]
, 2017 This project aims to develop a greater understanding of how old drugs can be repurposed into new and exciting therapeutic areas. In particular, developing an understanding of the antibacterial mode of action exerted by modified benzodiazepines possessing
MA, SHUWEN
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Lipid phosphatases and related proteins: from regulation of phospholipid metabolism to filopodia formation [PDF]
, 2007 Phospholipids and sphingolipids play critical roles in signal transduction, intracellular membrane trafficking, and control of cell growth and survival.
Sigal, Yury J.
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Crystallographic studies on membrane and cytoplasmic enzymes [PDF]
, 2013 Dissertation presented to obtain the Ph.D degree in Biochemistry, Structural BiochemistryHaloacid dehalogenase (HAD) superfamily (CL0137), includes a diverse range of enzymes that use an aspartate carboxylate as nucleophile (Aravind et al., 1998 ...
Nogly, Przemyslaw
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The role of the C8 proton of ATP in the regulation of phosphoryl transfer within kinases and synthetases [PDF]
, 2011 Background The kinome comprises functionally diverse enzymes, with the current classification indicating very little about the extent of conserved regulatory mechanisms associated with phosphoryl transfer.
Kenyon, Colin P +5 more
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Characterization of a Phosphonate-Specific Cytidylyltransferase [PDF]
, 2016 Antibiotic resistance is a major global health concern that requires new therapeutic approaches. Furthermore, a lack of narrow spectrum antibiotics on the market produces unintended consequences with respect to changes in our microbial make up ...
Batul, Kissa
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DISCOVERY OF NOVEL MURAYMYCIN ANTIBIOTICS AND INSIGHT INTO THE BIOSYNTHETIC PATHWAY [PDF]
, 2018 New antibiotics with novel targets or mechanisms of action are needed to counter the steady emergence of bacterial pathogens that are resistant to antibiotics used in the clinic.
Cui, Zheng
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Prevalence and mechanisms of aminoglycoside-resistance in clinical isolates in Hong Kong. [PDF]
, 1996 by Chin Miu Ling, Nathalie.Thesis (M.Phil.)--Chinese University of Hong Kong, 1996.Includes bibliographical references (leaves 130-143).ABSTRACT --- p.iACKNOWLEDGEMENTS --- p.iiiLIST OF TABLES --- p.viiLIST OF FIGURES --- p.xINTRODUCTION --- p ...
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Studies on the mechanism of action of arginine kinase [PDF]
, 2018 Smith, Elizabeth
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Synthesis Of Netilmicin And Apramycin Derivatives For The Treatment Of Multidrug-Resistant Infectious Diseases [PDF]
, 2017 The ever-growing bacterial resistance to existing antibiotics is alarming to humanity. Many researchers decided to revisit aminoglycosides with renewed emphasis on chemical modification as they have long been used as highly potent antibiotics for ...
Sonousi, Amr Sayed Motawi
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