MicrobiologyOpen, Volume 14, Issue 4, August 2025.Pseudomonas loganensis sp. nov., is a novel strain identified through genomic and biochemical analysis, exhibits salt and pH tolerance, and harbors biosynthetic gene clusters for turnerbactin, carotenoids, and trehalose, highlighting its potential in agriculture and industrial biotechnology.
Melisa Z. Karaman +3 more
wiley +1 more source
Measuring catalytic mechanism similarity – a new approach to study enzyme function and evolution
The FEBS Journal, Volume 292, Issue 16, Page 4200-4210, August 2025.We introduce a previously undescribed computational method to measure the similarity of enzyme mechanisms, enabling comparison of catalytic steps across hundreds of enzymes. Applying this method to a database of enzyme mechanisms demonstrated its ability to automatically uncover functional and evolutionary relationships, independently of sequence and ...
Antonio J. M. Ribeiro +5 more
wiley +1 more source
MOZART, a QSAR Multi-Target Web-Based Tool to Predict Multiple Drug–Enzyme Interactions [PDF]
Developing models able to predict interactions between drugs and enzymes is a primary goal in computational biology since these models may be used for predicting both new active drugs and the interactions between known drugs on untested targets. With the
Concu, Riccardo +3 more
core +1 more source
CATALYTIC MECHANISM AND FUNCTION EVOLVEMENT STUDIES OF PHOSPHATASES WITHIN HALOACID DEHALOGENASE SUPERFAMILY (HADSF) [PDF]
, 2013 The haloacid dehalogenase superfamily (HADSF) is one of the largest known enzyme superfamilies, having more than 32,000 nonredundant members. Enzymes in this superfamily catalyze a number of different chemical reactions including dehalogenation ...
Zheng, Li
core +1 more source
Advanced Science, Volume 12, Issue 18, May 15, 2025.Traditional Chinese Medicine (TCM), while holistic and historically esteemed, faces challenges in “miracle cures” due to slow onset, long cycles, and difficulty controlling quality. This study obtains the active ingredients, glabridin (GLA) and puerarin (PUE), from Ge‐Gen Decoction (GGD), developing a safe and effective drug delivery system, GLA‐PUE ...
Jianhong Qi +7 more
wiley +1 more source
Synthesis Of Apramycin And Paromomycin Derivatives As Potential Next Generation Aminoglycoside Antibiotics And Chemistry Of Isothiocyanato Sialyl Donors [PDF]
, 2016 AGAs are clinically important antibacterials for human therapy and have long been used as highly potent antibiotics for treating several bacterial infections.
Mandhapati, Appi Reddy
core +1 more source
, 2016 In the United States, binge drinking is considered a ‘normal’ experience among teens and young adults; however, excessive alcohol consumption often results in severe or even fatal consequences.
A. Carlin +4 more
semanticscholar +1 more source
Structural and functional characterization of the aminoacetone utilization microcompartment from Mycobacterium smegmatis MC2 155 [PDF]
, 2019 Bacterial microcompartments are proteinacious complexes made by bacteria, which metabolize volatile or cytotoxic chemicals, by sequestering a series of reactions within a selectively permeable shell.
Mallette, Evan
core +1 more source
HMGA1 drives stem cell, inflammatory pathway, and cell cycle progression genes during lymphoid tumorigenesis [PDF]
, 2011 Background Although the high mobility group A1 (HMGA1) gene is widely overexpressed in diverse cancers and portends a poor prognosis in some tumors, the molecular mechanisms that mediate its role in transformation have remained elusive.
A Belton +88 more
core +3 more sources
Structure and mechanism of the RNA polymerase II CTD phosphatase Scp1 and large-scale preparation of the RNA polymerase II-TFIIF complex [PDF]
, 2006 TFIIF is the only general transcription factor that has been implicated in the preinitiation complex assembly, open complex formation, initiation and transcription elongation. In addition, TFIIF stimulates Fcp1, a central phosphatase needed for recycling
Kamenski, Tomislav
core