PHOSPHOMANNOMUTASE 2-CONGENITAL DISORDER OF GLYCOSYLATION: A CASE REPORT AND LITERATURE REVIE [PDF]
精准医学杂志, 2023 Objective To investigate the clinical and genetic features of patients with phosphomannomutase 2 (PMM2)-congenital disorder of glycosylation (CDG), and to provide a basis for the early diagnosis of PMM2-CDG. Methods A retrospective analysis was performed
WMENG Qiutong, ZHANG Tian, RAN Ni, YANG Zhaochuan, FU Peng, SHAN Yanchun
doaj +1 more source
Evolutionary Analysis and Functional Characterization of Different Histidinol Phosphate Phosphatases [PDF]
, 2023 The elaborate metabolism of modern organisms raises the question of how such a complex system could have developed from a simple ancient prestage with a presumably very limited repertoire of enzymes.
Kinateder, Thomas
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Identification and cloning of a novel phosphatase expressed at high levels in differentiating growth plate chondrocytes [PDF]
, 1999 Growth plate chondrocytes progress through a proliferative phase before acquiring a terminally-differentiated phenotype. In this study we used Percoll density gradients to separate chick growth plate chondrocytes into populations of different ...
Farquharson, C +6 more
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Quantitative comparison of catalytic mechanisms and overall reactions in convergently evolved enzymes : implications for classification of enzyme function [PDF]
, 2010 The authors thank the National Institutes of Health (NIH R01 GM60595 to PCB) and the Scottish Universities Life Sciences Alliance (SULSA to JBOM) for funding.Functionally analogous enzymes are those that catalyze similar reactions on similar substrates ...
Daniel E. Almonacid +124 more
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Murine CMP-sialic acid synthetase : structural analysis of the C-terminal domain and biochemical characterisation of nuclear localisation [PDF]
, 2008 [no ...
Oschlies, Melanie
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Structure guided insight into function, mechanism, and evolution in a phosphoryl- and phosphoglycosyl- transferase superfamily [PDF]
, 2021 The haloalkanoate dehalogenase (HAD) and monotopic phosphoglycosyl transferase (monoPGT) superfamilies were used to study structure/function relationships and protein evolution.
O'Toole, Katherine Hennessey
core
Substrate specificity and conformational activation mechanism of beta-phosphoglucomutase [PDF]
, 2016 Phosphate transfer is ubiquitous in nature, however the occurance of phosphomutases is rare. Their uniqueness can be attributed to the complex and malleable substrate recognition scheme that allows the enzyme to perform two similar, yet distinct ...
Saltzberg, Daniel John
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COMPARATIVE APPROACHES FOR PLANT GENOMES: UNRAVELING "INTRA" AND "INTER" SPECIES RELATIONSHIPS FROM PRELIMINARY GENE ANNOTATIONS [PDF]
, 2016 Comparative genomics studies the differences and similarities between different species, to transfer biological information from model organisms to newly sequenced genomes, and to understand the evolutionary forces that drive changes in genomic features ...
Ambrosino, Luca
core
YZGD pyridoxal phosphatase from P. thiaminolyticus; subcloning, expression, and purification for x-ray crystallography structure determination [PDF]
, 2008 The HAD superfamily contains enzymes that catalyze carbon or phosphate transfer reactions. One family within the HAD superfamily is the p-nitrophenyl phosphatase (PNPPase) family.
Strassner, Amanda M.
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Function assignment within the haloacid dehalogenase superfamily [PDF]
, 2012 The HaloacidDehalogenase Enzyme Superfamily (HADSF) is a ubiquitous family of enzymes. Presently, more than 45,000 deposited gene sequences encode proteins of the HADSF, and only a fraction of these have defined structure and/or function.
huang, hua
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