Binding determinants for substrates and inhibitors of trehalose-6-phosphate phosphatase [PDF]
Trehalose is a sugar commonly found in archaeon, bacteria, fungi, plants, and invertebrates. It is utilized as an energy source and upregulated during stress conditions such as thermal fluctuations and oxidative stress.
Harvey, Christine Marie
core
CATALYTIC MECHANISM AND FUNCTION EVOLVEMENT STUDIES OF PHOSPHATASES WITHIN HALOACID DEHALOGENASE SUPERFAMILY (HADSF) [PDF]
The haloacid dehalogenase superfamily (HADSF) is one of the largest known enzyme superfamilies, having more than 32,000 nonredundant members. Enzymes in this superfamily catalyze a number of different chemical reactions including dehalogenation ...
Zheng, Li
core +1 more source
Crystallographic studies on membrane and cytoplasmic enzymes [PDF]
Dissertation presented to obtain the Ph.D degree in Biochemistry, Structural BiochemistryHaloacid dehalogenase (HAD) superfamily (CL0137), includes a diverse range of enzymes that use an aspartate carboxylate as nucleophile (Aravind et al., 1998 ...
Nogly, Przemyslaw
core
Quantitative and evolutionary global analysis of enzyme reaction mechanisms [PDF]
The most widely used classification system describing enzyme-catalysed reactions is the Enzyme Commission (EC) number. Understanding enzyme function is important for both fundamental scientific and pharmaceutical reasons.
Nath, Neetika
core
ENZYMES: Catalysis, Kinetics and Mechanisms [PDF]
Onemarvelsattheintricate designoflivingsystems,andwecannotbutwonderhow life originated on this planet. Whether ?rst biological structures emerged as the selfreproducing genetic templates (genetics-?rst origin of life) or the metabolic universality ...
N. S. Punekar
core
Evolution of structure and function among hotdog-fold thioesterases and HAD family phosphatases [PDF]
My doctoral research began with the function assignment to two domains of fusion protein BT4699, from Bacteriodes thetaiotaomicron, BF1314 from Bacteriodes fragilis and PG1653 from Porphyromonas gingivalis.
Min, Wang
core +1 more source
Discovery and characterization of a novel class of metabolic regulators in the malaria parasite Plasmodium falciparum [PDF]
The malaria parasite, Plasmodium falciparum, infects hundreds of millions of people per year and causes hundreds of thousands of deaths. Within the host red blood cell, the parasite relies on glycolysis for energy and synthesis of essential biomolecules.
Guggisberg, Ann Marie
core +1 more source
ESTUDIO GENÓMICO Y PROTEÓMICO DE CEPAS PROBIÓTICAS DE Lactobacillus pentosus AISLADAS DE ACEITUNAS ALOREÑA FERMENTADAS [PDF]
Nuestro objetivo fue analizar en profundidad las propiedades probióticas de las cepas de Lactobacillus pentosus aisladas de la fermentación natural de la aceituna Aloreña para así seleccionar cepas con el mejor potencial probiótico.
Pérez Montoro, Beatriz
core +1 more source
Dual functions of the retinal determination gene network member EYES ABSENT as a transcription factor and protein phosphatase [PDF]
Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept.
Brown, Serena Jean Silver
core
Regulation of cell fate by phosphorylation : a tale of two transcription factors [PDF]
Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Biology, 2004.Includes bibliographical references.As transcription factors are the nuclear effectors of signaling cascades, mechanisms must exist to specifically regulate their activities ...
Tootle, Tina Louise
core

