Drug-Induced Photosensitivity: Clinical Types of Phototoxicity and Photoallergy and Pathogenetic Mechanisms [PDF]
Frontiers in Allergy, 2022 Drug-induced photosensitivity (DIP) is a common cutaneous adverse drug reaction, resulting from the interaction of ultraviolet radiations, mostly ultraviolet A, with drugs. DIP includes phototoxicity and photoallergy.
Natasha Irrera +2 more
exaly +6 more sources
Toward Animal-Free Phototoxicity Testing: A Keratinocyte-Based UVA Screening Assay to Distinguish Photoirritation From Photoallergy [PDF]
ToxicsPhototoxicity represents an increasing concern due to the presence of photoreactive chemicals in consumer products, including household products, pharmaceuticals, and cosmetic formulations.
Elisabet Teixido +2 more
exaly +5 more sources
Journal of Immunotoxicology, 2019 FMX101 4% contains 4% micronized minocycline (as an HCl) formulated in a lipophilic foam vehicle for topical administration. FMX101 4% has been shown to be an effective and well-tolerated treatment for moderate-to-severe acne in three Phase 3 pivotal ...
Iain Stuart
exaly +3 more sources
Innovative Strategies for Photoallergy Assessment: Breaking Free From Animal Models in Cosmetic Ingredient Development [PDF]
CosmeticsPhotoallergy, a unique form of skin sensitization induced by specific compounds under ultraviolet irradiation, has traditionally been investigated using animals.
Adriana Solange Maddaleno +2 more
exaly +4 more sources
Latest Evidence Regarding the Effects of Photosensitive Drugs on the Skin: Pathogenetic Mechanisms and Clinical Manifestations [PDF]
Pharmaceutics, 2020 Photosensitivity induced by drugs is a widely experienced problem, concerning both molecule design and clinical practice. Indeed, photo-induced cutaneous eruptions represent one of the most common drug adverse events and are frequently an important issue
Flavia Lozzi +10 more
doaj +5 more sources
PhotoChem Reference Chemical Database for the Development of New Alternative Photosafety Test Methods [PDF]
ToxicsPhotosafety assessments are a key requirement for the safe development of pharmaceuticals, cosmetics, and agrochemicals. Although in vitro methods are widely used for phototoxicity and photoallergy testing, their limited applicability and predictive ...
Ga-Young Lee +4 more
doaj +3 more sources
JDDG: Journal der Deutschen Dermatologischen Gesellschaft, 2015 SummaryMany – topically applied or systemically administered – substances may trigger photoallergic skin reactions following exposure to ultraviolet (UV) radiation. While most cases represent photoallergic contact dermatitis due to topically applied agents, systemically triggered photoallergy is considerably less common.
Anna, Wilm, Mark, Berneburg
core +4 more sources
Contact Sensitization and Phototoxic and Photoallergic Potential of Tirbanibulin 1% Ointment in Healthy Volunteers [PDF]
JID Innovations, 2023 Tirbanibulin 1% ointment is approved for the topical treatment of actinic keratosis, applied once daily for 5 days. Three phase 1 randomized, single-center, controlled, within-subject comparison studies were conducted to evaluate the sensitization (KX01 ...
Jonathan Dosik +3 more
doaj +2 more sources
Drug-Induced Photosensitivity—From Light and Chemistry to Biological Reactions and Clinical Symptoms [PDF]
Pharmaceuticals, 2021 Photosensitivity is one of the most common cutaneous adverse drug reactions. There are two types of drug-induced photosensitivity: photoallergy and phototoxicity. Currently, the number of photosensitization cases is constantly increasing due to excessive
Justyna Kowalska +3 more
doaj +2 more sources
Revista da Sociedade Portuguesa de Dermatologia e Venereologia, 2022 Drug photosensitivity is a relatively frequent adverse event, although not always recognized due to its clinical polymorphism and difficulties in performing tests to prove drug causality.
Ana S. Pereira +2 more
doaj +3 more sources