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Drug-Induced Photosensitivity: Clinical Types of Phototoxicity and Photoallergy and Pathogenetic Mechanisms [PDF]
Frontiers in Allergy, 2022 Drug-induced photosensitivity (DIP) is a common cutaneous adverse drug reaction, resulting from the interaction of ultraviolet radiations, mostly ultraviolet A, with drugs. DIP includes phototoxicity and photoallergy.
Natasha Irrera +2 more
exaly +4 more sources
Contact Sensitization and Phototoxic and Photoallergic Potential of Tirbanibulin 1% Ointment in Healthy Volunteers [PDF]
JID Innovations, 2023 Tirbanibulin 1% ointment is approved for the topical treatment of actinic keratosis, applied once daily for 5 days. Three phase 1 randomized, single-center, controlled, within-subject comparison studies were conducted to evaluate the sensitization (KX01 ...
Jonathan Dosik +3 more
doaj +2 more sources
Photoallergy to Naproxen. [PDF]
Cureus, 2021 Reactions caused by photosensitivity, also called photodermatosis, are cutaneous reactions induced or exacerbated by exposure to electromagnetic radiation, including UV radiation, visible light, and infrared radiation. We present the case of a 41-year-old man with no personal history of allergy and who is referred to our Drug Allergy Unit for study. We
Rojas Perez-Ezquerra P +4 more
europepmc +5 more sources
Drug-Induced Photosensitivity—From Light and Chemistry to Biological Reactions and Clinical Symptoms [PDF]
Pharmaceuticals, 2021 Photosensitivity is one of the most common cutaneous adverse drug reactions. There are two types of drug-induced photosensitivity: photoallergy and phototoxicity. Currently, the number of photosensitization cases is constantly increasing due to excessive
Justyna Kowalska +3 more
doaj +2 more sources
Photosensitivity Reactions Induced by Photochemical Degradation of Drugs [PDF]
Advanced Pharmaceutical Bulletin, 2022 Photochemical degradation of drugs can lead to degradation products with potential toxic or allergizing effects for the human body. A significant amount of work has been carried out over the past few decades to clarify the molecular mechanism of ...
Hajnal Klelemen +3 more
doaj +2 more sources
PhotoChem Reference Chemical Database for the Development of New Alternative Photosafety Test Methods [PDF]
ToxicsPhotosafety assessments are a key requirement for the safe development of pharmaceuticals, cosmetics, and agrochemicals. Although in vitro methods are widely used for phototoxicity and photoallergy testing, their limited applicability and predictive ...
Ga-Young Lee +4 more
doaj +2 more sources
Latest Evidence Regarding the Effects of Photosensitive Drugs on the Skin: Pathogenetic Mechanisms and Clinical Manifestations [PDF]
Pharmaceutics, 2020 Photosensitivity induced by drugs is a widely experienced problem, concerning both molecule design and clinical practice. Indeed, photo-induced cutaneous eruptions represent one of the most common drug adverse events and are frequently an important issue
Flavia Lozzi +10 more
doaj +2 more sources
Journal of Immunotoxicology, 2019 FMX101 4% contains 4% micronized minocycline (as an HCl) formulated in a lipophilic foam vehicle for topical administration. FMX101 4% has been shown to be an effective and well-tolerated treatment for moderate-to-severe acne in three Phase 3 pivotal ...
Iain Stuart
exaly +2 more sources
CosmeticsPhotoallergy, a unique form of skin sensitization induced by specific compounds under ultraviolet irradiation, has traditionally been investigated using animals.
Adriana Solange Maddaleno +2 more
exaly +3 more sources
Japanese Journal of Clinical Immunology, 2011 Photoallergy is an entity of allergy in the dermatological field. Sunlight is involved in the pathophysiology of photoallergy. Photoallergy is classified into intrinsic and extrinsic diseases. As extrinsic diseases, photosensitivity due to drugs and photocontact dermatitis are important for physicians as well as dermatologists.
exaly +4 more sources