Results 311 to 320 of about 180,433 (381)

Photo‐Empowered Macrophage‐Based Drug Delivery System Overcomes Motility Suppression and Significantly Enhances Deep Tumor Drug Delivery

open access: yesAdvanced Science, EarlyView.
This study develops a photo‐empowered macrophage‐based (PEM) drug delivery system that provides a novel and effective solution for restoring cellular motility to enhance drug delivery and overcome hypoxia‐induced multidrug resistance. The construction of the PEM system fully exploits the unique biological properties of macrophages and the energy ...
Zhaoming Fu   +10 more
wiley   +1 more source

Recent Advances in Mediator and Proton Relay Usage in Molecular Catalysis

open access: yesAdvanced Science, EarlyView.
The use of electron–proton transfer mediators, redox mediators, and proton relays in synergy with molecular catalysts in energy‐related small‐molecule and organic transformations is discussed, with a focus on recent advances. Linear free‐energy relationship and catalytic Tafel plots provide a systematic foundation for benchmarking these catalytic ...
Yu‐Lin Chi   +3 more
wiley   +1 more source

Stimuli‐Responsive Supramolecular Biomaterials for Cancer Theranostics

open access: yesAdvanced Science, EarlyView.
The ultimate goal of cancer theranostics is to get imaging agents and therapeutic cargo to tumor sites when and where they are required. “Smart” systems should be developed. This review discusses the characteristics of physiological stimuli, types and action modes of external stimuli, construction approaches and working principles, as well as ...
Wenting Hu   +4 more
wiley   +1 more source

Electronic and Steric Tuning of Molecular Acidity toward Unified Models for Excited State Proton Transfer

open access: yesAdvanced Science, EarlyView.
Conventional excited‐state proton transfer (ESPT) theories explain the kinetics of fluorescent photoacids, but face challenges for weakly or nonfluorescent ones. This missing link is bridged by making and dissecting series of green fluorescent protein chromophore derivatives with varied photoacidities via strategic substitutions. Structure‐photoacidity
Cheng Chen   +3 more
wiley   +1 more source

Photochemical Rearrangements of Pyridine N-Oxides: Pathways to Oxaziridine Derivatives. [PDF]

open access: yesMolecules
Guerra CJ   +11 more
europepmc   +1 more source

Smart Nanoparticles Disrupting Energy Supply through Triple Mechanisms to Kill Tumors via Dual Disruption of Mitochondria and Lysosomes

open access: yesAdvanced Science, EarlyView.
This study introduces a biomimetic nanoplatform (MTCA@C) designed for precise cancer therapy. It targets mitochondria to induce dysfunction through photodynamic activation, while concurrently blocking mitophagy via lysosomal alkalinization. The platform further triggers methuosis, resulting in tumor cell death through vacuolization and energy pathway ...
Xiao Xu   +6 more
wiley   +1 more source

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