Results 31 to 40 of about 1,784 (116)

Copper in cancer: friend or foe? Metabolism, dysregulation, and therapeutic opportunities

Cancer Communications, Volume 45, Issue 5, Page 577-607, May 2025.
Abstract Copper, one of the essential nutrients for the human body, acts as an electron relay in multiple pathways due to its redox properties. Both deficiencies and excesses of copper lead to cellular fragility. Therefore, it can manifest pro‐ and anti‐cancer properties in tumors. Therefore, it is crucial to clarify the copper activity within the cell.
Dan Shan, Jinling Song, Yuqing Ren, Yuyuan Zhang, Yuhao Ba, Peng Luo, Quan Cheng, Hui Xu, Siyuan Weng, Anning Zuo, Shutong Liu, Xinwei Han, Jinhai Deng, Zaoqu Liu   +13 more
wiley   +1 more source

Photodynamic therapy in actinic cheilitis: clinical and anatomopathological evaluation of 19 patients Tratamento de queilite actínica com terapia fotodinâmica: avaliação clínica e anatomopatológica de 19 pacientes

Anais Brasileiros de Dermatologia, 2012
BACKGROUND: Actinic cheilitis, a common disease caused by chronic solar exposure and tobacco use, is considered a premalignant lesion with potential to develop into squamous cell carcinoma.
Camila Ferrari Ribeiro, Fernanda Homem de Mello de Souza, Juliana Merheb Jordão, Letícia Cortes Haendchen, Lismary Mesquita, Juliano Vilaverde Schmitt, Luciana Lisboa Faucz   +6 more
doaj   +1 more source

Light-Enhanced Cytotoxicity of Doxorubicin by Photoactivation

Cells, 2023
The combination of photodynamic therapy with chemotherapy (photochemotherapy, PCT) can lead to additive or synergistic antitumor effects. Usually, two different molecules, a photosensitizer (PS) and a chemotherapeutic drug are used in PCT. Doxorubicin is
Giulia Greco, Luca Ulfo, Eleonora Turrini, Alessia Marconi, Paolo Emidio Costantini, Tainah Dorina Marforio, Edoardo Jun Mattioli, Matteo Di Giosia, Alberto Danielli, Carmela Fimognari, Matteo Calvaresi   +10 more
doaj   +1 more source

Alopecia Areata: Pathogenesis, Diagnosis, and Therapies

MedComm, Volume 6, Issue 5, May 2025.
This review probed into the immune factors in the pathogenesis of AA, focusing on the small molecule drugs and biologics for the treatment of AA, and anticipated the research direction in terms of the pathogenesis and targeted therapy of AA. It aims to emphasize the necessity for further exploration of its immunological pathogenesis and therapeutic ...
Tianyou Ma, Tingrui Zhang, Fengze Miao, Jun Liu, Quangang Zhu, Zhongjian Chen, Zongguang Tai, Zhigao He   +7 more
wiley   +1 more source

Clinical and Microbiological Effects of Photodynamic Therapy Associated with Non-surgical Treatment in Aggressive Periodontitis

Journal of Dental Research, Dental Clinics, Dental Prospects, 2014
Background and aims. The aim of this study was to compare the effectiveness of adjunctive photodynamic therapy (PDT) in the treatment of aggressive periodontitis. Materials and methods.
Mohammad Taghi Chitsazi, Adileh Shirmohammadi, Reza Pourabbas, Nader Abolfazli, Ilnaz Farhoudi, Behrouz Daghigh Azar, Farrokh Farhadi   +6 more
doaj   +1 more source

Dual Targeting Biomimetic Carrier‐Free Nanosystems for Photo‐Chemotherapy of Rheumatoid Arthritis via Macrophage Apoptosis and Re‐Polarization

Advanced Science, Volume 12, Issue 10, March 13, 2025.
In this manuscript, a dual‐targeting biomimetic carrier‐free nanosystem (BMC) is developed for synergistic photo‐chemotherapy of RA. Upon near‐infrared laser irradiation, BMC can not only synergistically kill anti‐inflammatory M1 macrophages, but also induce macrophages to reprogram into anti‐inflammatory M2 macrophages, as well as activate the cells ...
Guanghe Xue, Huimei Jiang, Zhenhua Song, Yifan Zhao, Wen Gao, Bai Lv, Jie Cao   +6 more
wiley   +1 more source

A Surgical Approach for Stable Lesions of Linear Scleroderma

Kaohsiung Journal of Medical Sciences, 2010
A 29-year-old Japanese woman presented with alopecia lesions in her occipital region and was diagnosed as linear scleroderma. Topical steroids along with psoralen and UVA light therapy were applied, but the lesion persisted.
Hiroshi Kato, Yoichi Shintani, Yuji Yamaguchi, Akimichi Morita   +3 more
doaj   +1 more source

Recent Perspectives on Anticancer Potential of Coumarin Against Different Human Malignancies: An Updated Review

Food Science &Nutrition, Volume 13, Issue 1, January 2025.
The paper highlights coumarin's ability to induce apoptosis, inhibit cell proliferation, and interfere with cancer cell signaling pathways. Coumarin disrupts key signaling pathways, including NF‐κB and PI3K/Akt, which are crucial for cancer cell survival and proliferation.
Muhammad Shahbaz, Asfa Perween, Ushna Momal, Muhammad Imran, Muhammad Hammad Ul Hassan, Hammad Naeem, Ahmed Mujtaba, Muzzamal Hussain, Suliman A. Alsagaby, Waleed Al Abdulmonem, Mohamed A. Abdelgawad, Ahmed H. El‐Ghorab, Samy Selim, Ehab M. Mostafa, Entessar Al Jbawi   +14 more
wiley   +1 more source

Reduction of Multispecies Biofilms on an Acrylic Denture Base Model by Antimicrobial Photodynamic Therapy Mediated by Natural Photosensitizers

Pharmaceuticals
Objectives: The aim of this study is to investigate the antimicrobial efficacy of antimicrobial photodynamic therapy (PDT) using natural photosensitizers (curcumin, riboflavin, and phycocyanin) and light-emitting diode (LED) irradiation against ...
Ali Shahi Ardakani, Stefano Benedicenti, Luca Solimei, Sima Shahabi, Shima Afrasiabi   +4 more
doaj   +1 more source

Combination Therapy With CGF and Microneedling‐Assisted Compound Betamethasone for Resistant Alopecia Areata: A Pilot Study

Journal of Cosmetic Dermatology, Volume 24, Issue 1, January 2025.
ABSTRACT Background Alopecia areata (AA), an autoimmune disorder characterized by hair loss, can be particularly difficult to manage when patients do not respond to standard therapeutic approaches such as topical or injectable corticosteroids, contact immunotherapy, and systemic treatments.
Lingling Jia, Changjiang Zhao, Hongyi Zhang, Hua Jiang, Jiachao Xiong, Yufei Li   +5 more
wiley   +1 more source