Results 41 to 50 of about 193,535 (345)

Crystal structure, epitope, and functional impact of an antibody against a superactive FVIIa provide insights into allosteric mechanism

open access: yesResearch and Practice in Thrombosis and Haemostasis, 2019
Background Blood coagulation factor VIIa (FVIIa) plays its critical physiological role in the initiation of hemostasis. Even so, recombinant FVIIa is successfully used as a bypassing agent for factor VIII or IX in the treatment of bleeds in patients with
Longguang Jiang   +4 more
doaj   +1 more source

Spatial Distribution of a Porphyrin-Based Photosensitizer Reveals Mechanism of Photodynamic Inactivation of Candida albicans

open access: yesFrontiers in Medicine, 2021
The antimicrobial photodynamic therapy (aPDT) is a promising approach for the control of microbial and especially fungal infections such as mucosal mycosis.
Thomas Voit   +8 more
doaj   +1 more source

Application of Photosensitive Chitosan-based Composite Films in the Preservation of Litopenaeus vannamei

open access: yesShipin gongye ke-ji, 2023
The purpose of this paper was to study the application of a fresh preservation mode of composite film-photodynamic technology to delay the quality deterioration of Litopenaeus vannamei.
Shuangjie WU   +6 more
doaj   +1 more source

Light Sources and Dosimetry Techniques for Photodynamic Therapy

open access: yesPhotochemistry and Photobiology, 2020
Effective treatment delivery in photodynamic therapy (PDT) requires coordination of the light source, the photosensitizer, and the delivery device appropriate to the target tissue.
Michele M. Kim, A. Darafsheh
semanticscholar   +1 more source

An unexpected strategy to alleviate hypoxia limitation of photodynamic therapy by biotinylation of photosensitizers

open access: yesNature Communications, 2022
The most common working mechanism of photodynamic therapy is based on high-toxicity singlet oxygen, which is called Type II photodynamic therapy. But it is highly dependent on oxygen consumption.
Jing An   +9 more
semanticscholar   +1 more source

Folic acid-modified phthalocyanine-nanozyme loaded liposomes for targeted photodynamic therapy [PDF]

open access: yes, 2021
The hypoxic tumour microenvironment and poor spatiotemporal localization of photosensitizers are two significant obstacles that limit practical applications of photodynamic therapy. In response, a biocompatible, light-activatable liposome integrated with
Abrahams, Garth   +7 more
core   +1 more source

Self-assembled single-atom nanozyme for enhanced photodynamic therapy treatment of tumor

open access: yesNature Communications, 2020
Hypoxia of solid tumor compromises the therapeutic outcome of photodynamic therapy (PDT) that relies on localized O2 molecules to produce highly cytotoxic singlet oxygen (1O2) species. Herein, we present a safe and versatile self-assembled PDT nanoagent,
Dongdong Wang   +10 more
semanticscholar   +1 more source

Supramolecular photodynamic agents for simultaneous oxidation of NADH and generation of superoxide radical

open access: yesNature Communications, 2022
Given that Type-I photosensitizers (PSs) have hypoxia tolerance, developing general approaches to prepare Type-I PSs is of great importance, but remains a challenge.
Kun-Xu Teng   +3 more
semanticscholar   +1 more source

Antimicrobial effects of photodynamic therapy with Fotoenticine on Streptococcus mutans isolated from dental caries [PDF]

open access: yes, 2021
Photodynamic therapy (PDT) is a promising strategy to control cariogenic pathogens, such as Streptococcus mutans. Seeking to reach the total bacterial elimination from dental surfaces, novel photosensitizers have been investigated, such as Fotoenticine ...
Strixino, Juliana Ferreira   +26 more
core   +1 more source

An open source and reduce expenditure ROS generation strategy for chemodynamic/photodynamic synergistic therapy

open access: yesNature Communications, 2020
The therapeutic effect of reactive oxygen species (ROS)-involved cancer therapies is significantly limited by shortage of oxy-substrates, such as hypoxia in photodynamic therapy (PDT) and insufficient hydrogen peroxide (H2O2) in chemodynamic therapy (CDT)
Cong-Hui Liu   +7 more
semanticscholar   +1 more source

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