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CHAPTER 3. Basic Biological Mechanisms of Photodynamic Diagnosis/Photodynamic Therapy
2016Biological processes in photodynamic diagnosis and tumor therapy start with the delivery of a suitable photosensitizer (PS), transportation via the vasculature and selective accumulation in the tumor, including tumor cells, tumor vessels, extracellular matrix, stroma cells and immune cells.
B. Krammer, T. Verwanger
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Photodynamic Therapy and Photodynamic Diagnosis for Head and Neck Cancer
Practica Oto-Rhino-Laryngologica, 2009Photodynamic therapy (PDT) is recognized as one of the treatment options for early stage cancers. This treatment is a first-line treatment for carcinoma based on a photochemical reaction in which a photosensitizer is excited by laser irradiation, causing selective death of tumor tissue.
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mTHPC-mediated Photodynamic Diagnosis of Malignant Brain Tumors¶
Photochemistry and Photobiology, 2001Radical tumor resection is the basis for the prolonged survival of patients suffering from malignant brain tumors such as glioblastoma multiforme. We have carried out a phase-II study involving 22 patients with malignant brain tumors to assess the feasibility and the effectiveness of the combination of intraoperative photodynamic diagnosis and ...
A, Zimmermann +2 more
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Block Copolymer Nanoassemblies for Photodynamic Therapy and Diagnosis
Therapeutic Delivery, 2013Light can be a powerful therapeutic and diagnostic tool. Light-sensitive molecules can be used to develop locally targeted cancer therapeutics. This approach is known as photodynamic therapy (PDT). Similarly, it is possible to diagnose diseases and track the course of treatment in vivo using ligh-sensitive molecules.
Matthew, Dickerson, Younsoo, Bae
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Photodynamic Diagnosis in Urology: State-of-the-Art
European Urology, 2008To provide an overview on the methodology and clinical relevance of fluorescence diagnosis with exogenous fluorochromes or fluorochrome prodrugs in urology.The methodology is summarised on the basis of our experience and the relevant literature. Clinical results and perspectives are reported and concluded after we scanned and evaluated sources from ...
Dieter, Jocham +2 more
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Photodynamic diagnosis in surgery for spinal ependymoma
Journal of Neurosurgery: Spine, 2006Protoporphyrin IX (PPIX), a metabolic product of 5-aminolevulinic acid (5-ALA) accumulating specifically in tumor tissue, shows fluorescence on exposure to excitation light having a peak wavelength of 405 6 1 nm (laser spectrum overlaps that of ultraviolet light), and thus it allows detection of small amounts of tumor.
Satoru, Shimizu +5 more
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Photodynamic Diagnosis and Therapy and the Brain
2010Photodynamic techniques such as photodynamic diagnosis (PDD), fluorescence-guided tumour resection (FGR) and photodynamic therapy (PDT) are currently undergoing intensive clinical investigations as adjuvant treatment for malignant brain tumours. The following chapter provides an overview on the current clinical data and trials of PDT as well as ...
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Photodynamic Therapy and Fluorescence Diagnosis of Skin Cancers
2002In several countries throughout the world the photosensitizer porfimer-sodium has been approved for systemic photodynamic therapy (PDT) for different oncological indications. However, owing to the prolonged photosensitization entailed, the use of this porphyrin derivative is restricted.
Rolf-Markus, Szeimies +1 more
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Quail Chorioallantoic Membrane - A Tool for Photodynamic Diagnosis and Therapy.
Journal of Visualized Experiments, 2022M. Máčajová +5 more
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