Results 1 to 10 of about 13,836,709 (221)

Fluorescence‐based discrimination of breast cancer cells by direct exposure to 5‐aminolevulinic acid

Cancer Medicine, 2019
Protoporphyrin IX‐fluorescence measurement is a powerful in situ approach for cancer detection after oral/topical administration of 5‐aminolevulinic acid.
Midori Morita, Hideo Tanaka, Yasuaki Kumamoto, Akihiro Nakamura, Yoshinori Harada, Takehiro Ogata, Koichi Sakaguchi, Tetsuya Taguchi, Tetsuro Takamatsu   +8 more
doaj   +1 more source

Neuroprotective effects of 5-aminolevulinic acid against neurodegeneration in rat models of Parkinson's disease and stroke

Journal of Pharmacological Sciences, 2020
Oxidative stress is associated with the progression of the neurodegenerative diseases Parkinson's disease (PD) and cerebral ischemia. Recently, 5-aminolevulinic acid (5-ALA), an intermediate in the porphyrin synthesis pathway, was reported to exert ...
Masanori Hijioka, Kanori Kitamura, Daijiro Yanagisawa, Kaneyasu Nishimura, Kazuyuki Takata, Masatoshi Inden, Yoshihisa Kitamura   +6 more
doaj   +1 more source

Bioquímica e ação citotóxica de alfa-aminocetonas endógenas Biochemistry and cytotoxicity of alpha-aminoketones

Química Nova, 2005
alpha-Aminoketones are expected to undergo enolization and subsequent aerobic oxidation yielding oxyradicals and highly toxic a-oxoaldehydes. Our interest has been focused on two endogenous a-aminoketones: 5-aminolevulinic acid (ALA) and aminoacetone (AA)
Fernando Dutra, Etelvino J. H. Bechara
doaj   +1 more source

Natural 5-Aminolevulinic Acid: Sources, Biosynthesis, Detection and Applications

Frontiers in Bioengineering and Biotechnology, 2022
5-Aminolevulinic acid (5-ALA) is the key precursor for the biosynthesis of tetrapyrrole compounds, with wide applications in medicine, agriculture and other burgeoning fields. Because of its potential applications and disadvantages of chemical synthesis,
Meiru Jiang, Kunqiang Hong, Yufeng Mao, Hongwu Ma, Tao Chen, Zhiwen Wang   +5 more
doaj   +1 more source

Stability of 5-aminolevulinic acid in aqueous solution

European Journal of Pharmaceutical Sciences, 1999
The chemical stability of 5-aminolevulinic acid (ALA) was studied in aqueous solution as a function of concentration, pH, temperature and in the presence of ethylenediaminetetraacetic acid (EDTA). The degradation of ALA was followed by reversed-phase liquid chromatography using a pH where ALA is protonated (pKa1=3.90; pKa2=8.
B, Elfsson, I, Wallin, S, Eksborg, K, Rudaeus, A M, Ros, H, Ehrsson   +5 more
openaire   +2 more sources

5-Aminolevulinic acid photoactivated over planktonic and biofilm forms of Enterococcus faecalis as a pharmacological therapy alternative

Brazilian Journal of Pharmaceutical Sciences, 2020
The purpose of the study was to evaluate the antibacterial effect of protoporphyrin IX (PpIX) generated by the exogenous administration of 5-aminolevulinic acid or δ-ALA and activated with an argon laser over a planktonic and biofilm of Enterococcus ...
Adriana Beltran-Leal, Abraham Muñoz-Ruiz, Vicente Esparza-Villalpando, Yolanda Castro, Amaury Pozos-Guillen, Héctor Flores   +5 more
doaj   +1 more source

5-Aminolevulinic acid photodynamic diagnosis of laryngeal papillomatosis

Медицинский совет, 2019
Photodynamic diagnosis is a promising method in the treatment of laryngeal papillomatosis, which includes an assessment of the increased visual and spectrometric contrast of papillomatosis masses against the background of the introduction of the ...
I. G. Guseinov, K. Sh. Davudov, T. I. Garashchenko, I. I. Nazhmudinov, V. V. Vavin, B. K. Davudova, K. M. Magomedova, M. Yu. Khoranova, B. Z. Abdullaev   +8 more
doaj   +1 more source

Evolutionary Trend Analysis of Research on 5-ALA Delivery and Theranostic Applications Based on a Scientometrics Study

Pharmaceutics, 2022
5-aminolevulinic acid (5-ALA) has been extensively studied for its sustainability and broad-spectrum applications in medical research and theranostics, as well as other areas.
You Zhou, Mulan Mo, Dexu Luo, Yi Yang, Jialin Hu, Chenqing Ye, Longxiang Lin, Chuanshan Xu, Wenjie Chen   +8 more
doaj   +1 more source

Derivatives of 5-Aminolevulinic Acid for Photodynamic Therapy

Perspectives in Medicinal Chemistry, 2007
Photodynamic therapy (PDT) is a clinical treatment that combines the effects of visible light irradiation with subsequent biochemical events that arise from the presence of a photosensitising drug (possessing no dark toxicity) to cause destruction of selected cells. Today, the most common agent used in dermatological PDT is 5-aminolevulinic acid (ALA).
Ryan F, Donnelly, Paul A, McCarron, A David, Woolfson   +2 more
openaire   +2 more sources

Severe hypotension and postoperative cardiac arrest caused by 5-aminolevulinic acid: a case report

Journal of Medical Case Reports
Background Although 5-aminolevulinic acid is useful for the photodynamic diagnosis of bladder tumors, it often causes severe intraoperative hypotension.
Taishi Miyazaki, Shinya Taguchi, Norihiko Obata, Satoshi Mizobuchi   +3 more
doaj   +1 more source