Growth-coupled selection of 5-aminolevulinic acid synthetase mutants for 5-aminolevulinic acid biosynthesis in Corynebacterium glutamicum [PDF]
Frontiers in MicrobiologyIntroduction5-Aminolevulinic acid (5-ALA) is a nonprotein amino acid with broad applications in agriculture, medicine, and the food industry. In recent years, substantial efforts have been devoted to enhancing its biosynthesis.
Peng Yang +11 more
doaj +5 more sources
5-Aminolevulinic acid improves chicken sperm motility [PDF]
Animal Bioscience, 2021 Objective This study investigated the effects of 5-aminolevulinic acid (5-ALA) on the motility parameters, mitochondrial membrane depolarization, and ATP levels in chicken sperm. Methods The pooled semen from Barred Plymouth Rock males was used.
Shin Taniguchi +4 more
doaj +4 more sources
5-Aminolevulinic acid hydrochloride
IUCrDataThe crystal structure of 5-aminolevulinic acid hydrochloride (systematic name: 4-carboxy-2-oxobutan-1-aminium chloride), C5H10NO3+·Cl−, has been solved and refined using synchrotron X-ray powder diffraction data, and optimized using density functional ...
Jean guillaume Ducreux +3 more
doaj +2 more sources
Effect of 5-aminolevulinic Acid on Mitochondrial Activity
Frontiers in Bioscience-Scholar, 2023 Background: Mitochondrial dysfunction is considered an important mechanism in the pathogenesis of various diseases. Therefore, mitochondria are currently being considered as subjects for targeted therapies, particularly, phototherapy using 5 ...
Yuliya V. Markina +6 more
doaj +3 more sources
Supplementation of 5-Aminolevulinic Acid Suppressed Body Weight Loss and Reduced Disease Severity During Eimeria tenella Infection in Broiler Chickens [PDF]
The Journal of Poultry ScienceThis study aimed to evaluate the effects of 5-aminolevulinic acid (5-ALA) supplementation in broiler chickens infected with Eimeria tenella. To assess these effects, chickens supplemented with 20 ppm 5-ALA (5-ALA group) were compared ...
Taqi Ahmad Hanif +2 more
doaj +2 more sources
Case Report: Lack of Response to Givosiran in a Case of ALAD Porphyria
Frontiers in Genetics, 2022 Introduction: 5-Aminolevulinic acid dehydratase (ALAD) porphyria (ADP) is an autosomal recessive disease characterized by a profound deficiency in ALAD, the second enzyme in the heme biosynthetic pathway, and acute neurovisceral attacks with abdominal ...
Erica Graff +3 more
doaj +1 more source
Biomedical Photonics, 2023 Acne is one of the most common skin conditions in the world. A number of studies have shown that photodynamic therapy (PDT) is safe and effective for both inflammatory and non-inflammatory acne and can significantly improve skin conditions in this ...
E. V. Filonenko, V. I. Ivanova-Radkevich
doaj +1 more source
Photodynamic therapy using systemic administration of 5-aminolevulinic acid and a 410-nm wavelength light-emitting diode for methicillin-resistant Staphylococcus aureus-infected ulcers in mice. [PDF]
PLoS ONE, 2014 Bacterial resistance to antibiotics has become a worldwide problem. One potential alternative for bacterial control is photodynamic therapy. 5-aminolevulinic acid is a natural precursor of the photosensitizer protoporphyrin IX. Relatively little is known
Kuniyuki Morimoto +6 more
doaj +1 more source
Photodynamic therapy of psoriasis
Biomedical Photonics, 2023 Photodynamic therapy (PDT) in the treatment of psoriasis remains the subject of much debate. There is no consensus in the scientific community about effective and safe PDT regimens for psoriasis.
E. V. Filonenko, V. Ivanova-Radkevich
doaj +1 more source
Synthetic biology-instructed transdermal microneedle patch for traceable photodynamic therapy
Nature Communications, 2022 5-Aminolevulinic acid-based photodynamic therapy heavily depends on the biological transformation efficiency of 5-aminolevulinic acid to protoporphyrin IX, while the lack of an effective delivery system and imaging navigation are major hurdles in ...
Gang He +7 more
doaj +1 more source