Results 31 to 40 of about 13,836,709 (221)

Systems metabolic engineering of Escherichia coli for hyper-production of 5‑aminolevulinic acid

Biotechnology for Biofuels and Bioproducts, 2023
Background 5-Aminolevulinic acid (5-ALA) is a promising biostimulant, feed nutrient, and photodynamic drug with wide applications in modern agriculture and therapy.
Wei Pu, Jiuzhou Chen, Yingyu Zhou, Huamin Qiu, Tuo Shi, Wenjuan Zhou, Xuan Guo, Ningyun Cai, Zijian Tan, Jiao Liu, Jinhui Feng, Yu Wang, Ping Zheng, Jibin Sun   +13 more
doaj   +1 more source

Sequential Design of Activatable Photosensitizers for Ablation of Glioma Cells in Brain Cancer Tissues

Angewandte Chemie, EarlyView.
Gal‐SeNBD‐oleamide is an activatable photosensitizer (PS) with efficient uptake and selective, β‐galactosidase‐triggered activation in cancer cells, enabling efficient photodynamic ablation of glioma cells directly in brain tissue slices from mouse preclinical models and human glioblastoma patients.
Utsa Karmakar, Zhiming Cheng, Andrew D. M. Green, Sam Benson, Eleni Nestoros, Clarissa Lim, Justyna Cholewa‐Waclaw, Fabio de Moliner, Paula Lusarreta, Deborah Seah, Alsadeg Bilal, Neza Alfazema, Thibaud Aymoz‐Bressot, Gillian Morrison, Sonja Vermeren, Steven M. Pollard, Paul M. Brennan, Michael G. Tanner, Marc Vendrell   +18 more
wiley   +2 more sources

5-Aminolevulinic acid: A matter of life and caveats

Journal of Photochemistry and Photobiology, 2021
Our mini-review concerns the potential adverse pro-oxidant role of 5-aminolevulinic (ALA), the first protoporphyrin IX (PP-IX)/heme precursor widely used in commercial formulations for endogenous photodynamic therapy (PDT).
Etelvino J.H. Bechara, Luiz D. Ramos, Cassius V. Stevani   +2 more
doaj   +1 more source

5-Aminolevulinic acid synthesis in Escherichia coli [PDF]

Journal of Bacteriology, 1989
A hemA mutant of Escherichia coli containing a multicopy plasmid which complemented the mutation excreted 5-aminolevulinic acid (ALA) into the medium. [1-14C]glutamate was substantially incorporated into ALA by this strain, whereas [2-14C]glycine was not. Periodate degradation of labeled ALA showed that C-5 of ALA was derived from C-1 of glutamate. The
J M, Li, O, Brathwaite, S D, Cosloy, C S, Russell   +3 more
openaire   +2 more sources

Comparative Effectiveness of 5-Aminolevulinic Acid Photodynamic Therapy

, 2022
Comparative Effectiveness of 5-Aminolevulinic Acid Photodynamic Therapy with No Incubation Versus One-Hour Incubation for the Treatment of Actinic Keratosis: A Randomized-Controlled ...
Alam, M
core   +2 more sources

X-ray structure of a putative reaction intermediate of 5-aminolaevulinic acid dehydratase

, 2003
The X-ray structure of yeast 5-aminolaevulinic acid dehydratase, in which the catalytic site of the enzyme is complexed with a putative cyclic intermediate composed of both substrate moieties, has been solved at 0.16 nm (1.6 Å) resolution.
Youell, J.H., Butler, D., Cooper, J.B., Erskine, P.T., Warren, M.J., Brindley, A.A., Shoolingin-Jordan, P.M., Wood, S.P., Coates, L.   +8 more
core   +1 more source

Effect of 5-aminolevulinic acid-based photodynamic therapy via reactive oxygen species in human cholangiocarcinoma cells [PDF]

, 2011
Cy Hyun Kim1,2, Chung-Wook Chung1, Kyung Ha Choi1, Jin-Ju Yoo1, Do Hyung Kim1,2, Young-IL Jeong1, Dae Hwan Kang1,21National Research and Development Center for Hepatobiliary Cancer, Research Institute for Convergence of Biomedical Science and Technology,
Jeong YI, Kim DH, Chung CW, Dae Hwan Kang, Kang DH, Kim CH, Chung-Wook Chung, Yoo JJ, Choi KH   +8 more
core   +1 more source

Photodynamic diagnosis for skull invasion [PDF]

, 2008
OBJECTIVE: We present a case of a meningioma in which photodynamic diagnosis (PDD) using 5-aminolevulinic acid was very useful in identifying the cranial involvement. CLINICAL PRESENTATION: An 83-year-old woman presented with a bony, hard, immobile bulge
Nagata, Izumi, Hayashi, Yukishige, Suyama, Kazuhiko, Morofuji, Yoichi, Matsuo, Takayuki   +4 more
core   +1 more source

Beyond a dual role: how Purpureocillium lilacinum reprograms citrus metabolism for integrated biocontrol and growth promotion

Journal of the Science of Food and Agriculture, EarlyView.
Abstract BACKGROUND Plants harbor complex microbial communities that are fundamental to their health and productivity. Among them, endophytic fungi such as Purpureocillium lilacinum establish mutualistic associations, offering dual benefits as plant growth promoters and biocontrol agents.
Sana Bouzembila, Kamel Charaabi, Haytham Hamden, Salma Fadhel, Nesrine Tanfouri, Meriem Msaad Guerfali   +5 more
wiley   +1 more source

5-Aminolevulinic acid fermentation using engineered Saccharomyces cerevisiae

Microbial Cell Factories, 2019
Background 5′-Aminolevulinic acid (ALA) is widely used in the pharmaceutical industry, healthcare, and food production, and is a substrate for the biosynthesis of heme, which is required for respiration and photosynthesis. Enhancement of ALA biosynthesis
Kiyotaka Y. Hara, Masaru Saito, Hiroko Kato, Kana Morikawa, Hiroshi Kikukawa, Hironari Nomura, Takanori Fujimoto, Yoko Hirono-Hara, Shigeyuki Watanabe, Kengo Kanamaru, Akihiko Kondo   +10 more
doaj   +1 more source