Results 31 to 40 of about 34,838 (281)

Perspective review of what is needed for molecular-specific fluorescence-guided surgery [PDF]

, 2018
Molecular image-guided surgery has the potential for translating the tools of molecular pathology to real-time guidance in surgery. As a whole, there are incredibly positive indicators of growth, including the first United States Food and Drug ...
Achilefu, Samuel, Pogue, Brian W., Rosenthal, Eben L., van Dam, Gooitzen M.   +3 more
core   +4 more sources

Stability of 5-aminolevulinic acid in aqueous solution

European Journal of Pharmaceutical Sciences, 1999
The chemical stability of 5-aminolevulinic acid (ALA) was studied in aqueous solution as a function of concentration, pH, temperature and in the presence of ethylenediaminetetraacetic acid (EDTA). The degradation of ALA was followed by reversed-phase liquid chromatography using a pH where ALA is protonated (pKa1=3.90; pKa2=8.
B, Elfsson, I, Wallin, S, Eksborg, K, Rudaeus, A M, Ros, H, Ehrsson   +5 more
openaire   +2 more sources

Acute Hepatic Porphyrias: Review and Recent Progress. [PDF]

, 2019
The acute hepatic porphyrias (AHPs) are a group of four inherited diseases of heme biosynthesis that present with episodic, acute neurovisceral symptoms.
Andant, Anderson, Andersson, Badawy, Balwani, Bissell, Bissell, Bloomer, Bonkovsky, Bonkovsky, Bonkovsky, Bonkovsky, Bonkowsky, Bonkowsky, Bonkowsky, Bylesjo, Chen, D’Avola, Ferrer, Glueck, Handschin, Jeans, Lambrecht, Lane, Marsden, McGuire, Pallet, Sardh, Sardh, Shen, Singal, Stein, Stewart, Tchernitchko, Wahlin, Watson, Watson, Willandt, Wu, Yarra, Yasuda   +40 more
core   +1 more source

Laser-induced generation of singlet oxygen and its role in the cerebrovascular physiology [PDF]

, 2017
For over 55 years, laser technology has expanded from laboratory research to widespread fields, for example telecommunication and data storage amongst others.
Bragina, O. A., Gekaluyk, A. S., Goltsov, Alexey, Rafailov, E. U., Saranceva, E. I., Semyachkina-Glushkovskaya, O. V., Sokolovski, S. G., Tuchin, V. V.   +7 more
core   +2 more sources

A Deep‐Red‐Absorbing Osmium(II) Complex as a Photosensitizer for Photodynamic Therapy Inducing Immunogenic Cell Death

Angewandte Chemie, EarlyView.
A deep‐red‐excited osmium(II) photosensitizer (Os2) induces immunogenic cell death (ICD) under 740 nm irradiation and triggers robust anti‐tumor immune responses both in vitro and in vivo. ABSTRACT Immunogenic cell death (ICD), which converts tumor cells into their own vaccine, plays a pivotal role in the development of novel anticancer therapies. Here,
Yiyi Zhang, Pierre Mesdom, Eduardo Izquierdo‐García, João P. M. António, Ruonan Gao, Bruno Saubaméa, Johanne Seguin, Morgane Moinard, Philippe Arnoux, Céline Frochot, Kevin Cariou, Bich‐Thuy Doan, Gilles Gasser   +12 more
wiley   +2 more sources

Fluorescence‐based discrimination of breast cancer cells by direct exposure to 5‐aminolevulinic acid

Cancer Medicine, 2019
Protoporphyrin IX‐fluorescence measurement is a powerful in situ approach for cancer detection after oral/topical administration of 5‐aminolevulinic acid.
Midori Morita, Hideo Tanaka, Yasuaki Kumamoto, Akihiro Nakamura, Yoshinori Harada, Takehiro Ogata, Koichi Sakaguchi, Tetsuya Taguchi, Tetsuro Takamatsu   +8 more
doaj   +1 more source

Novel pathway for corrinoid compounds production in lactobacillus [PDF]

, 2018
Vitamin B12 or cobalamin is an essential metabolite for humans, which makes it an interesting compound for many research groups that focus in different producer-strains synthesis pathways.
Font, Graciela Maria, Saavedra, Maria Lucila, Taranto, Maria Pia, Torres, Andrea Carolina, Vannini, María Verónica   +4 more
core   +2 more sources

5-Aminolevulinic acid hydrochloride

IUCrData
The crystal structure of 5-aminolevulinic acid hydrochloride (systematic name: 4-carboxy-2-oxobutan-1-aminium chloride), C5H10NO3+·Cl−, has been solved and refined using synchrotron X-ray powder diffraction data, and optimized using density functional ...
Jean guillaume Ducreux, James A. Kaduk, Anja Dosen, Thomas N. Blanton   +3 more
doaj   +1 more source

Neuroprotective effects of 5-aminolevulinic acid against neurodegeneration in rat models of Parkinson's disease and stroke

Journal of Pharmacological Sciences, 2020
Oxidative stress is associated with the progression of the neurodegenerative diseases Parkinson's disease (PD) and cerebral ischemia. Recently, 5-aminolevulinic acid (5-ALA), an intermediate in the porphyrin synthesis pathway, was reported to exert ...
Masanori Hijioka, Kanori Kitamura, Daijiro Yanagisawa, Kaneyasu Nishimura, Kazuyuki Takata, Masatoshi Inden, Yoshihisa Kitamura   +6 more
doaj   +1 more source

5-Aminolevulinic acid: A matter of life and caveats

Journal of Photochemistry and Photobiology, 2021
Our mini-review concerns the potential adverse pro-oxidant role of 5-aminolevulinic (ALA), the first protoporphyrin IX (PP-IX)/heme precursor widely used in commercial formulations for endogenous photodynamic therapy (PDT).
Etelvino J.H. Bechara, Luiz D. Ramos, Cassius V. Stevani   +2 more
doaj   +1 more source