Results 51 to 60 of about 13,836,709 (221)

Disseminated Xanthogranuloma Harboring a GAB2::BRAF Fusion and MITF Pathogenic Variant Successfully Treated With Cobimetinib: A Rare Case Report

Journal of Cutaneous Pathology, EarlyView.
ABSTRACT Several activating mutations and gene fusions involving the mitogen‐activated protein kinase (MAPK) pathway have appeared in the literature regarding histiocytic neoplasms. We identified a GAB2::BRAF fusion in a cutaneous lesion of a 36‐year‐old male who developed central diabetes insipidus and reddish‐pink grouped papules on the bilateral ...
Pauline C. Xu, Allison M. Cushman‐Vokoun, Christopher R. D’Angelo, Dinesh Pradhan   +3 more
wiley   +1 more source

Methotrexate enhances 5-aminolevulinic acid-mediated photodynamic therapy-induced killing of human SCC4 cells by upregulation of coproporphyrinogen oxidase

, 2017
Background/Purpose: Topical 5-aminolevulinic acid-mediated photodynamic therapy (ALA-PDT) is effective for treatment of oral precancerous and cancerous lesions. This in vitro study tried to examine whether the SCC4 cell killing by ALA-PDT was enhanced by
Yang, Deng-Fu; Lee, Jeng-Woei; Chen, Hsin-Ming; Huang, Zheng; Hsu, Yih-Chih
core   +1 more source

Enhanced Delivery of 5‐Aminolevulinic Acid by Lecithin Invasomes in 3D Melanoma Cancer Model [PDF]

, 2023
Photodynamic therapy (PDT) is a noninvasive therapeutic approach for the treatment of skin cancer and diseases. 5-Aminolevulinic acid is a prodrug clinically approved for PDT.
Alfredo Zito, Annalisa Caputo, Andrea Ragusa, Clara Piccirillo, Raffaele Filotico, Luca Salvatore, Gabriella Guida, Alessandra Quarta, Antonio Gaballo, Alessia Nito, Nunzia Gallo, Concetta Nobile, and Alessandra Quarta   +12 more
core   +1 more source

Photodynamic therapy in the treatment of patients with mycosis fungoides

Biomedical Photonics, 2022
The review highlights the current understanding of the epidemiology, etiology, pathogenesis, existing classifications of mycosis fungoides. Methods for diagnosis and treatment of the pathology are described, among which photodynamic therapy (PDT) plays ...
E. V. Filonenko, V. I. Ivanova-Radkevich
doaj   +1 more source

Unraveling the active site cover of coproheme decarboxylase from Listeria monocytogenes

The FEBS Journal, EarlyView.
During heme biosynthesis in Gram‐positive bacteria, coproheme decarboxylase (ChdC) catalyzes the conversion of four‐propionate substrate coproheme to the two propionate product heme b. Its active site is universally covered by a flexible linking loop. This study identifies an important histidine residue, which stabilizes the loop in a ChdC homolog.
Nikolaus Falb, Dominik Hörtnagel, Chris Oostenbrink, Paul G. Furtmüller, Stefan Hofbauer   +4 more
wiley   +1 more source

5-Aminolevulinic acid-mediated photodynamic therapy for oral cancers and precancers

, 2014
Previous studies have used both systemic and topical 5-aminolevulinic acid (ALA)-mediated photodynamic therapy (PDT) to treat.oral precancers including oral leukoplakia (DL), oral erythroleukoplakia (DEL), and oral verrucous hyperplasia (OVH) as well as ...
Chen, Hsin-Ming;Yu, Chuan-Hang;Lin, Hung-Pin;Cheng, Shih-Jung;Chiang, Chun-Pin, 江俊斌 ;陳信銘 ;鄭世榮   +1 more
core   +1 more source

Awake magic: glioblastoma resection under 5-aminolevulinic acid guidance during awake craniotomy. A case report with video demonstration [PDF]

Ķazaķstannyṇ Klinikalyķ Medicinasy
An awake craniotomy's primary goal is to remove the tumor or damaged cells as much as possible without affecting the patient's capacity for clear thought or other crucial functions.
Aidos Moldabekov, Aiman Maidan, Nurzhan Ryskeldiyev, Nurali Ashirov, Serik Akshulakov   +4 more
doaj   +1 more source

Topical methotrexate pretreatment enhances the therapeutic effect of topical 5-aminolevulinic acid-mediated photodynamic therapy on hamster buccal pouch precancers

, 2017
Background/Purpose: Topical 5-aminolevulinic acid-mediated photodynamic therapy (ALA-PDT) is effective for treatment of human oral precancerous lesions.
Yang, Deng-Fu; Lee, Jeng-Woei; Chen, Hsin-Ming; Hsu, Yih-Chih
core   +1 more source

Photodynamic therapy in the treatment of onychomycosis – a review

Przegląd Dermatologiczny, 2017
Toenail onychomycosis is a common infection, affecting up to 14% of the population. Moreover, poor penetration of topical drugs into the nail bed leads to frequent recurrences of the disease. The cure rate of toenail onychomycosis is estimated at 63–76%.
Katarzyna Kalinowska, Anita Hryncewicz-Gwóźdź   +1 more
doaj   +1 more source

MdPHYB2‐MdPIF1 Module Regulates Transcription Factors to Mediate Light‐Dependent ALA‐Induced Apple Anthocyanin Biosynthesis

Plant, Cell &Environment, EarlyView.
ABSTRACT Light is a primary environmental signal that induces plant anthocyanin accumulation. The plant growth regulator 5‐aminolevulinic acid (ALA) has also been proven to effectively promote anthocyanin accumulation in apple. However, the underlying regulatory mechanisms remain unknown.
Liuzi Zhang, Yuyan An, Jianting Zhang, Liangju Wang   +3 more
wiley   +1 more source