Results 61 to 70 of about 15,420 (189)
PLoS ONE, 2015 Arabidopsis ubiquitin ligases ATL31 and homologue ATL6 control the carbon/nitrogen nutrient and pathogen responses. A mutant with the loss-of-function of both atl31 and atl6 developed light intensity-dependent pale-green true leaves, whereas the single ...
Shugo Maekawa +6 more
doaj +1 more source
Treatment of cutaneous lichen planus with ALA-mediated topical photodynamic therapy [PDF]
Journal of Innovative Optical Health Sciences, 2015 Purpose: To evaluate the effectiveness of topical 5-aminolevulinic acid (ALA)-mediated photodynamic therapy (PDT) for the treatment of cutaneous lichen planus (LP). Methods: A total of 17 symptomatic LP lesions in 7 Chinese patients were assessed.
Zhi-Xia Fan +5 more
doaj +1 more source
Antimicrobial photodynamic therapy in Candida spp. biofilms: In vitro and in vivo protocols
Photochemistry and Photobiology, EarlyView.This review addresses the critical challenges in translating in vitro antimicrobial photodynamic therapy protocols to in vivo models, with a particular focus on the hurdles of standardization. The vast diversity in photosensitizers and light parameters across different target cells and models requires a rigorous optimization process.
Lívia Mara Alves Figueiredo‐Godoi +2 more
wiley +1 more source
The effect of photodynamic therapy in head and neck cancer: A comprehensive review of in vivo models
Photochemistry and Photobiology, EarlyView.This review evaluates Photodynamic Therapy (PDT) in in vivo head and neck cancer models. PDT effectively generates ROS, reducing tumor growth, cell proliferation and angiogenesis while enhancing survival and immune responses. However, methodological heterogeneity highlights the urgent need for standardized dosimetric protocols to ensure reproducibility
Bibiana Padilha de Menezes da Silva +5 more
wiley +1 more source
Plant Biology, EarlyView.Overlap between Fe and Zn responsive gene regulatory networks (GRNs) were found, indicative of micronutrient crosstalk, and conservation of root and leaf GRNs and genes suggests strong constraint on homeostasis networks in plants. Abstract Micronutrient stress impacts growth, biomass production, and grain yield in crops.
A. Mishra +11 more
wiley +1 more source
Enzyme–MOF Composites: Quantitative Benchmarking and Evaluation of Biocatalyst Performance
Advanced Synthesis &Catalysis, Volume 368, Issue 13, 2 July 2026.Rigorous evaluation of enzyme@MOF composites requires quantitative benchmarking. This study illustrates this approach by applying and comparing enzyme‐loading and activity‐assessment strategies for two structurally and functionally distinct enzymes, phenolic acid decarboxylase, and cytochrome c.
Annika J. Weber +9 more
wiley +1 more source
Microneedle‐Assisted Systems for the Delivery of Proteolysis Targeting Chimeras (PROTACs)
Advanced Therapeutics, Volume 9, Issue 7, July 2026.The advent of Microneedle arrays has conferred a minimally invasive transdermal platform for the delivery of targeted protein‐degradation agents, especially Proteolysis‐Targeting Chimeras (PROTACs). By overcoming solubility and bioavailability barriers, this approach enhances localized cancer therapy.
Pooja Tiwary +5 more
wiley +1 more source
American Journal of Medical Genetics Part A, Volume 200, Issue 7, Page 1691-1695, July 2026.ABSTRACT Wilson disease (WD) is an autosomal recessive disorder of copper metabolism caused by ATP7B mutations. Diagnosis is usually straightforward in symptomatic patients, but can be challenging in children and adolescents with mild liver disease, borderline urinary copper excretion, or inconclusive genetic findings.
Emanuele Nicastro +10 more
wiley +1 more source
Scientific ReportsHeme serves as a prosthetic group in hemoproteins, including subunits of the mammalian mitochondrial electron transfer chain. The first enzyme in vertebrate heme biosynthesis, 5-aminolevulinic acid synthase 1 (ALAS1), is ubiquitously expressed and ...
Takeru Akabane +11 more
doaj +1 more source
Clinical Case Reports, Volume 14, Issue 7, July 2026.ABSTRACT Acute intermittent porphyria is a rare disorder causing neurotoxic precursor accumulation and severe neurological complications. We report a case progressing to tetraplegia and respiratory failure with delayed diagnosis. Treatment with hemin and givosiran resulted in prevention of attacks and functional recovery, highlighting the importance of
Natália Rebeca Alves de Araújo Karpejany +7 more
wiley +1 more source