Results 81 to 90 of about 34,838 (281)

Unraveling the active site cover of coproheme decarboxylase from Listeria monocytogenes

The FEBS Journal, EarlyView.
During heme biosynthesis in Gram‐positive bacteria, coproheme decarboxylase (ChdC) catalyzes the conversion of four‐propionate substrate coproheme to the two propionate product heme b. Its active site is universally covered by a flexible linking loop. This study identifies an important histidine residue, which stabilizes the loop in a ChdC homolog.
Nikolaus Falb, Dominik Hörtnagel, Chris Oostenbrink, Paul G. Furtmüller, Stefan Hofbauer   +4 more
wiley   +1 more source

Genetic factors affecting intraoperative 5-aminolevulinic acid-induced fluorescence of diffuse gliomas

Radiology and Oncology, 2017
In patients operated for malignant glioma, 5-aminolevulinic acid (5-ALA)-induced fluorescence guidance is useful. However, we occasionally experience instances of non-visible fluorescence despite a histopathological diagnosis of high-grade glioma.
Saito Kiyotaka, Hirai Toshinori, Takeshima Hideo, Kadota Yoshihito, Yamashita Shinji, Ivanova Asya, Yokogami Kiyotaka   +6 more
doaj   +1 more source

Agents for fluorescence-guided glioma surgery: a systematic review of preclinical and clinical results [PDF]

, 2016
Background: Fluorescence-guided surgery (FGS) is a technique used to enhance visualization of tumor margins in order to increase the extent of tumor resection in glioma surgery.
Aditya V. Karhade, David J. Cote, Ivo S. Muskens, Joeky T. Senders, Marike L. D. Broekman, Rosalie Schnoor, Timothy R. Smith   +6 more
core   +2 more sources

Divergent roles of ent‐kaurene oxidase paralogs in rice momilactone biosynthesis

Journal of Integrative Plant Biology, EarlyView.
Rice contains a five‐gene tandem array of genes encoding members of the ent‐kaurene oxidase (KO) family, with OsKOL4 and OsKOL5 playing divergent roles in momilactone metabolism, but both acting in the production of antifungal and antibacterial phytoalexins, which are important for disease resistance.
Zhibiao Wang, Yiling Feng, Leiming You, Meimei Xu, Kristin Helwig, Riqing Li, Si Nian Char, Bing Yang, Reuben J. Peters   +8 more
wiley   +1 more source

Pale-green phenotype of atl31atl6 double mutant leaves is caused by disruption of 5-aminolevulinic acid biosynthesis in Arabidopsis thaliana.

PLoS ONE, 2015
Arabidopsis ubiquitin ligases ATL31 and homologue ATL6 control the carbon/nitrogen nutrient and pathogen responses. A mutant with the loss-of-function of both atl31 and atl6 developed light intensity-dependent pale-green true leaves, whereas the single ...
Shugo Maekawa, Atsushi Takabayashi, Thais Huarancca Reyes, Hiroko Yamamoto, Ayumi Tanaka, Takeo Sato, Junji Yamaguchi   +6 more
doaj   +1 more source

Reactive oxygen species involved cancer cellular specific 5-aminolevulinic acid uptake in gastric epithelial cells [PDF]

, 2014
journal ...
HYODO Ichinosuke, Indo Hiroko P., Ito Hiromu, Majima Hideyuki J., MATSUI Hirofumi, Tamura Masato   +5 more
core   +1 more source

Immunomodulatory effects of photodynamic therapy for skin cancer: Potential strategies to improve treatment efficacy and tolerability

Photochemistry and Photobiology, EarlyView.
Photodynamic therapy (PDT) is a nonscarring treatment modality that is widely used for skin cancers and early squamous precursor lesions. PDT was previously thought to work primarily by killing cancer cells directly (via apoptosis or necrosis). However, more recent work indicates that a significant mechanism for PDT is the stimulation of anti‐cancer ...
Mark P. Ortenzio, Sanjay Anand, Jeffrey B. Travers, Edward V. Maytin, Craig A. Rohan   +4 more
wiley   +1 more source

Improvement of the Efficacy of 5-aminolevulinic Acid-mediated Photodynamic Treatment in Human Oral Squamous Cell Carcinoma HSC-4 [PDF]

, 2013
Ever since protoporphyrin IX (PpIX) was discovered to accumulate preferentially in cancer cells after 5-aminolevulinic acid (ALA) treatment, photodynamic treatment or therapy (PDT) has been developed as an exciting new treatment option for cancer ...
Fujita, Hirofumi, Inoue, Keiji, Katase, Naoki, Nagatsuka, Hitoshi, Ohuchi, Hideyo, Sasaki, Junzo, Utsumi, Kozo, Yamamoto, Masanao   +7 more
core   +1 more source

Photodynamic priming (PDP) targets platinum resistance from chronic perfluoroalkyl substances (PFAS) exposure in ovarian cancer cells

Photochemistry and Photobiology, EarlyView.
PFAS are environmental contaminants that induce chemoresistance in ovarian cancer cells. This study evaluated BPD‐PDP or ALA‐PpIX‐PDP in combination with carboplatin or doxorubicin to overcome PFAS‐induced chemoresistance in two cell cohorts: (i) PFAS chronically‐exposed and (ii) PFAS outgrown cells (which underwent a “recovery period” after chronic ...
Brittany P. Rickard, Meghan M. Dillon, Lauren A. Sapienza‐Lundie, Suzanne E. Fenton, Imran Rizvi   +4 more
wiley   +1 more source

Treatment of cutaneous lichen planus with ALA-mediated topical photodynamic therapy [PDF]

Journal of Innovative Optical Health Sciences, 2015
Purpose: To evaluate the effectiveness of topical 5-aminolevulinic acid (ALA)-mediated photodynamic therapy (PDT) for the treatment of cutaneous lichen planus (LP). Methods: A total of 17 symptomatic LP lesions in 7 Chinese patients were assessed.
Zhi-Xia Fan, Ling-Lin Zhang, Hong-Wei Wang, Pei-Ru Wang, Zheng Huang, Xiu-Li Wang   +5 more
doaj   +1 more source