Results 91 to 100 of about 34,838 (281)

Time‐series multi‐omics analysis of micronutrient stress in Sorghum bicolor reveals iron and zinc crosstalk and regulatory network conservation

Plant Biology, EarlyView.
Overlap between Fe and Zn responsive gene regulatory networks (GRNs) were found, indicative of micronutrient crosstalk, and conservation of root and leaf GRNs and genes suggests strong constraint on homeostasis networks in plants. Abstract Micronutrient stress impacts growth, biomass production, and grain yield in crops.
A. Mishra, A. Bhat, S. Kumari, R. Sharma, J. Braynen, D. Tadesse, S. El Alaoui, S. Seaver, N. Grosjean, D. Ware, M. Xie, T. Paape   +11 more
wiley   +1 more source

LCAA, a Novel Factor Required for Magnesium Protoporphyrin Monomethylester Cyclase Accumulation and Feedback Control of Aminolevulinic Acid Biosynthesis in Tobacco

, 2012
Low Chlorophyll Accumulation A (LCAA) antisense plants were obtained from a screen for genes whose partial down-regulation results in a strong chlorophyll deficiency in tobacco (Nicotiana tabacum).
Albus, C., Bock, R., Czarnecki, O., Grimm, B., Kahlau, S., Lein, W., Rothbart, M., Salinas, A., Schöttler, M., Thiele, W.   +9 more
core   +1 more source

The effect of 5-aminolevulinic acid on cytochrome c oxidase activity in mouse liver [PDF]

, 2011
Background 5-Aminolevulinic acid (ALA) is a precursor of heme that is fundamentally important in aerobic energy metabolism. Among the enzymes involved in aerobic energy metabolism, cytochrome c oxidase (COX) is crucial.
Shun-ichiro Ogura, Kouji Maruyama, Yuichiro Hagiya, Yuta Sugiyama, Kyoko Tsuchiya, Kiwamu Takahashi, Fuminori Abe, Kenji Tabata, Ichiro Okura, Motowo Nakajima, Tohru Tanaka   +10 more
core   +2 more sources

Zinc‐Coordination‐Driven Pyroptosis Nano‐Inductor Sensitizes Colorectal Cancer Chemo‐Immunotherapy by Specific Delivery and Cell Stemness Suppression

MedComm – Oncology, Volume 5, Issue 2, June 2026.
CD44‐targeted CNPs co‐deliver Zn2+ and MIT–ALA to CRC cells. Intracellularly, Zn2+ inhibits GLUT1‐dependent glycolysis, and ALA disrupts mitochondrial function, driving metabolic exhaustion in CSCs. This mitochondrial damage primes GSDMD‐mediated pyroptosis, accompanied by the release of pro‐inflammatory cytokines (IL‑1β, IL‑18).
Qinxia Chang, Wenting Cheng, Hailong Tian, Siyuan Qin, Yaying Zhang, Jing Zuo, Wenbing Pu, Shuaijun Lu, Na Xie   +8 more
wiley   +1 more source

Assembly of the precursor and processed light-harvesting chlorophyll a/b protein of Lemna into the light-harvesting complex II of barley etiochloroplasts. [PDF]

, 1986
When the in vitro synthesized precursor of a light-harvesting chlorophyll a/b binding protein (LHCP) from Lemna gibba is imported into barley etiochloroplasts, it is processed to a single form.
Chitnis, PR, Harel, E, Kohorn, BD, Thornber, JP, Tobin, EM   +4 more
core   +1 more source

The Keto Functions of Heme d1 Are Introduced by NirF and NirC

ChemBioChem, Volume 27, Issue 10, 27 May 2026.
During heme d1 biosynthesis, the proteins NirF and NirC together catalyze the formation of dihydro‐heme d1, thereby introducing the unique keto functions of heme d1. In this paper, the development of an in vitro enzyme activity assay for NirF/NirC is described, which demonstrates the function of the two proteins for the first time.
Pia Hebecker, Gunhild Layer
wiley   +1 more source

Topical photodynamic therapy using different porphyrin precursors leads to differences in vascular photosensitization and vascular damage in normal mouse skin [PDF]

, 2014
Different distributions of hexyl aminolevulinate (HAL), aminolevulinic acid (ALA) and methyl aminolevulinate (MAL) in the superficial vasculature are not well studied but they are hypothesized to play an important role in topical photodynamic therapy ...
Bruijn, H.S. (Riette) de, Haas, E.R.M. (Ellen) de, Middelburg, T.A. (Tom), Neumann, H.A.M. (Martino), Ploeg-van den Heuvel, A. (Angélique) van der, Robinson, D.J. (Dominic), Vijlder, H.C. (Hanke) de   +6 more
core   +1 more source

Soil applied silicon and manganese combined with foliar application of 5-aminolevulinic acid mediate photosynthetic recovery in Cd-stressed Salvia miltiorrhiza by regulating Cd-transporter genes [PDF]

, 2022
Yue-E Sun, Xin Li, Najeeb Ullah, Zhuoni Hou, Noman Ali Buttar, Zongqi Yang, Basharat Ali, Ling Xu   +7 more
openalex   +1 more source

Synthesis of Amines for Active Pharmaceutical Ingredients Using the Whole‐Cell Factory Saccharomyces Cerevisae

ChemBioChem, Volume 27, Issue 9, 14 May 2026.
This review highlights advances in engineering Saccharomyces cerevisiae for the sustainable biocatalytic production of pharmaceutically relevant amines, amino alcohols, amino acids, and complex alkaloids. It focuses on strategies to increase productivity, including enhanced enzyme expression, cofactor regeneration, precursor channeling, pathway ...
Natalia Kwiatos, Stephen Ossel, Francesco G. Mutti   +2 more
wiley   +1 more source

Heme deficiency in skeletal muscle exacerbates sarcopenia and impairs autophagy by reducing AMPK signaling

Scientific Reports
Heme serves as a prosthetic group in hemoproteins, including subunits of the mammalian mitochondrial electron transfer chain. The first enzyme in vertebrate heme biosynthesis, 5-aminolevulinic acid synthase 1 (ALAS1), is ubiquitously expressed and ...
Takeru Akabane, Hiromori Sagae, Koen van Wijk, Shinichi Saitoh, Tomohiro Kimura, Satoshi Okano, Ken Kodama, Kiwamu Takahashi, Motowo Nakajima, Tohru Tanaka, Michiaki Takagi, Osamu Nakajima   +11 more
doaj   +1 more source