Results 81 to 90 of about 17,416 (268)

Lethal photosensitisation of bacteria using Silica-TBO nanoconjugates [PDF]

, 2016
Pathogenic microorganisms are gradually becoming resistant to antibiotics, thereby novel antimicrobial technologies are urgently needed. Photodynamic therapy (PDT) is a process that employs the energy of photons to generate reactive oxygen species ...
Drexler, Sammy, Perni, Stefano, Prokopovich, Polina, Ruppel, Sergej   +3 more
core   +2 more sources

Rewiring NADH Metabolism Through NQO1‐Mediated Redox Cycling for Targeted Follicular Lymphoma Therapy

Advanced Science, EarlyView.
ABSTRACT Follicular lymphoma (FL) remains an incurable B‐cell malignancy with high relapse rates, and conventional therapies are often limited by significant toxicity, highlighting the need for novel treatments. We identified that FL exhibits markedly low expression of NAD(P)H: quinone oxidoreductase 1 (NQO1), a key enzyme required for activating ...
Jinxing Zhang, Ziqi Wang, Ye Weng, Yulin Fu, Yuelong Jiang, Beilin Zhuang, Wenzi Zeng, Xiangchun Zhang, Bing Xu, Jie Zha, Hongjun Zhuang   +10 more
wiley   +1 more source

H2S‐Amplified “Three‐in‐One” Antibacterial Strategy for Periodontitis Treatment Using a Photosensitive Pillararene‐Embedded COF/MOF Hybrid

Advanced Science, EarlyView.
The integration of ROS‐generating systems with H2S depletion strategies effectively overcomes the limitations imposed by endogenous antioxidant defenses on ROS‐based antimicrobial therapies. In this study, the Cu‐MOF is incorporated into pillararene‐embedded COF, achieving a “three‐in‐one” antimicrobial effect that markedly alleviated periodontal ...
Shuang Liang, Meng‐Hao Li, Liang Cheng, Tian‐Shou Zhang, Hui Hui, Yan Wang, Hong‐Pu Zhang, Bo‐Wen Liu, Lin Wang, Ying‐Wei Yang   +9 more
wiley   +1 more source

Fluorescence modulation of an aggregation-induced emission active ligand via rigidification in a coordination polymer and its application in singlet oxygen sensing

, 2019
A new Zn(II)-based coordination polymer (CP) having the formula [Zn(L)(2,2'-bpy)] (1) was synthesized using ZnCl2, 3,3'-(anthracene-9,10-diyl)diacrylic acid ligand (H2L), and 2,2'-bipyridine (2,2'-bpy) in DMF under solvothermal conditions.
Biswas, Shyam, Dalapati, Rana, Nandi, Soutick, Van Hecke, Kristof   +3 more
core   +2 more sources

Light-Independent Inactivation of Dengue-2 Virus by Carboxyfullerene C3 Isomer [PDF]

, 2000
Carboxyfullerene (C60) is known as a photosensitizer for virus inactivation. Its regioisomer with C3 symmetry, named the C3 isomer, could also inactivate the dengue-2 virus without light when the dose of C3 isomer was increased to 40 μM, indicating the ...
Lin, Yin-Ling, Lei, Huan-Yao, Wen, Yu-Ye, Luh, Tien-Yau, Chou, Cheng-Kung, Liu, Hsiao-Sheng   +5 more
core   +1 more source

Biomaterial design strategies for enhancing mitochondrial transplantation therapy

BMEMat, EarlyView.
Biomaterials to facilitate mitochondrial transplantation therapy: biomaterials as barriers to protect mitochondria from pathophysiological microenvironments, like osmotic stress caused by the excessive concentration of calcium ion, reactive oxygen species, and advanced glycation end products; biomaterials integrating with biochemical cues to improve ...
Shaoyang Kang, Yushan Zhang, Hang Li, Sirui Peng, Donghao Lyu, Chunxiao Zhou, Sheng Ding, Zujian Feng, Pingsheng Huang, Chuangnian Zhang, Hongjun Wang, Deling Kong, Weiwei Wang   +12 more
wiley   +1 more source

Nanomaterials‐mediated glycolysis rewriting to potentiate tumor immunotherapy

BMEMat, EarlyView.
This review systematically summarizes cutting‐edge advances in glycolysis‐rewiring nanomedicines, emphasizing their mechanisms in reversing immunosuppression and reinvigorating antitumor immune responses. Challenges in clinical translation and future directions for designing multifunctional metabolic‐immune modulators are also critically discussed ...
Zilin Ma, Songyan Li, Jie Yan, Xuechun Wang, Wen Zhao, Yunxuan Song, Dongdong Liu, Jianwei Jiao, Xiuying Duan, Guiqiang Zhang   +9 more
wiley   +1 more source

Photodynamic Inactivation of Endopathogenic Microbiota Using Curcumin- mediated Antimicrobial Photodynamic Therapy [PDF]

Journal of Sciences, Islamic Republic of Iran, 2018
Root canal disinfection is one of the main factors governing success of endodontic therapy. Antimicrobial photodynamic therapy (aPDT) is presented as a promising antimicrobial therapy that can eliminate microbiota present in infected root canal systems ...
M. Khoobi, Sh. Farkhonde Masoule, M. Pourhajibagher, J. Safari   +3 more
doaj   +1 more source

The anti-adhesive effect of curcumin on Candida albicans biofilms on denture materials [PDF]

, 2017
The use of natural compounds as an alternative source of antimicrobials has become a necessity given the growing concern over global antimicrobial resistance. Polyphenols, found in various edible plants, offers one potential solution to this. We aimed to
Alalwan, Hasanain, Combet, Emilie, Lappin, David F., Nile, Christopher J., Rajendran, Ranjith, Ramage, Gordon, Robertson, Douglas, Shahzad, Muhammad, Williams, Craig   +8 more
core   +1 more source

Targeting neutrophil extracellular traps in metabolic and immune niche: Nanomaterials for diabetes tissue regeneration

BMEMat, EarlyView.
The effects of NETs on regeneration of various diabetic tissues, and strategies targeting NETs for diabetes tissue regeneration. In the diabetic environment, NETs undergo complex metabolic and immune reprogramming, leading to dynamic changes in antibacterial and proinflammatory functions, and affecting regeneration of multiple systemic tissues.
Xinyi Jiang, Muxin Yue, Kai Mao, Boon Chin Heng, Noor Azlin Yahya, Yunsong Liu, Zheng Li   +6 more
wiley   +1 more source