Results 101 to 110 of about 123,739 (297)

Targeting Lactate and Lactylation in Cancer Metabolism and Immunotherapy

Advanced Science, EarlyView.
Lactate, once deemed a metabolic waste, emerges as a central regulator of cancer progression. This review elucidates how lactate and its epigenetic derivative, protein lactylation, orchestrate tumor metabolism, immune suppression, and therapeutic resistance.
Jiajing Gong, Yuhang Xie, Zhijie Weng, Yongzhi Wu, Longjiang Li, Bo Li   +5 more
wiley   +1 more source

NASA Light Emitting Diode Medical Applications from Deep Space to Deep Sea [PDF]

, 2001
This work is supported and managed through the NASA Marshall Space Flight Center-SBIR Program. LED-technology developed for NASA plant growth experiments in space shows promise for delivering light deep into tissues of the body to promote wound healing ...
Buchmann, Ellen V., Caviness, James, Cevenini, Vita, Chen, Gina, Cwiklinski, Joan, Gould, Lisa J., Hodgson, Brian D., Ignatius, Ron, Kane, Mary P., Martin, Todd, Meyer, Glenn A., Stinson, Helen, Turner, Scott G., Whelan, Harry T., Whelan, Noel T.   +14 more
core   +1 more source

Amplified singlet oxygen generation in metallated-porphyrin doped conjugated polymer nanoparticles [PDF]

, 2018
We report on the mechanism and efficiencies of singlet oxygen O2(1Δg) generation of nanoparticles (NP) of the conjugated polymer (CP) poly(9,9-dioctylfluorene-alt-benzothiadiazole) (F8BT) doped with platinum octaethylporphyrin (PtOEP) suspended in water.
Chesta, Carlos Alberto, Hernández, Laura, Ibarra, Luis Exequiel, Lorente, Carolina, Macor, Lorena Paola, Palacios, Rodrigo Emiliano, Ponzio, Rodrigo Andrés, Spada, Ramiro Martín   +7 more
core   +2 more sources

Visualization of Endosomal Escape of Intracellularly Delivered Protein With Unexpected Photochemical Internalization of Trypan Blue

Advanced Science, EarlyView.
TB, a conventional cell viability dye, acts as both a fluorescence modulator (quenching GFP fluorescence upon protein binding and recovering it upon release) and a photosensitizer that triggers endosomal escape via photochemical internalization (PCI) under 590 nm light.
Zhongqi Yao, Zhan Shi, Peng Hu, Changping Wang, Hui Wang   +4 more
wiley   +1 more source

Pharmaceutical and experimental-clinical aspects of photodynamic therapy combined with chemotherapy for malignant and premalignant tumors

Сибирский онкологический журнал
The aim of the study was to analyze the effectiveness of experimental and clinical photodynamic therapy combined with chemotherapy in the treatment of malignant and premalignant lesions. Material and methods.
Yu. S. Romanko, I. V. Reshetov
doaj   +1 more source

Intravital imaging reveals p53-dependent cancer cell death induced by phototherapy via calcium signaling. [PDF]

, 2014
One challenge in biology is signal transduction monitoring in a physiological context. Intravital imaging techniques are revolutionizing our understanding of tumor and host cell behaviors in the tumor environment.
Bonora, M, Giorgi, C, Mammano, Fabio, Missiroli, S, Morciano, G, Morganti, C, Pandolfi, Pp, Pinton, P., Poletti, F, Ramirez, Fg   +9 more
core   +3 more sources

Mitochondria and Neuromast Tagging With Fluorescent Gallium‐Triapine Analogues: In Cellulo MP FLIM and Zebrafish Live Imaging

Advanced Science, EarlyView.
Fluorescent BODIPY‐conjugated thiosemicarbazone ligands and their Ga(III), In(III), and Fe(III) complexes, inspired by Triapine, are developed as theranostic agents. Multiphoton FLIM and confocal microscopy in cancer cells and zebrafish reveal real‐time uptake, mitochondrial localisation, and whilst spectroscopic assays indicated preserved complex ...
Megan J. Green, Michael W. Jones, Merissa Saleem, Haobo Ge, Melita Tvardauskaite, Julia Dudzic, Fernando Cortezon‐Tamarit, Rory L. Arrowsmith, Charareh Pourzand, Gabriele Kociock‐Kohn, Nicholas H. Rees, Jonathan R. Dilworth, Stephen Faulkner, Stanley W. Botchway, David Gurevich, Sofia I. Pascu   +15 more
wiley   +1 more source

Assessing the Effect of Photodynamic Therapy on Peripheral Nerve and Cancer Cells Using a Thin Tissue Engineered Collagen Culture Model [PDF]

, 2008
not ...
MacRobert, A. J., Phillips, J. B., Wright, K. E.   +2 more
core   +1 more source

Leveraging Macrophage Metabolic Reprogramming for Enhanced Anti‐Tumor Immunity

Advanced Science, EarlyView.
Tumor‐associated macrophages (TAMs) are key regulators of the tumor microenvironment (TME), with their metabolic states playing a critical role in tumor progression or regression. This review summarizes current understanding of TAM metabolic plasticity alongside cutting‐edge bioengineering innovations, outlining a roadmap for transforming the ...
Zhiyun Liu, Lingyao Zeng, Xulin Gan, Yilin Zhou, Han Shen, Dan Wu, Xin Shou, Minmin Jiang, Liyun Shi   +8 more
wiley   +1 more source

Photodynamic Therapy for Esophageal cancer

Canadian Journal of Gastroenterology, 1990
In photodynamic therapy, a photosensitizing drug is injected and then activated by light in the red spectral region to produce reactive, highly toxic singlet oxygen, which causes cell tissue and damage.
R Lambert
doaj   +1 more source