Results 151 to 160 of about 21,611 (258)

Structural Mechanism of an Efficacy Photoswitch Targeting the β2‐adrenergic Receptor

Angewandte Chemie International Edition, Volume 65, Issue 18, 27 April 2026.
Time‐resolved structures from x‐ray free‐electron laser measurements combined with cellular assays demonstrate how the photoswitchable β‐blocker photoazolol‐1 acts as an efficacy switch of β2‐adrenergic receptor function. Light‐induced ligand repositioning shifts activity from inverse agonism toward neutral antagonism by altering local helical ...
Robin Stipp, Quentin Bertrand, Matilde Trabuco, Anna Duran‐Corbera, Maria Tindara Ignazzitto, Hannah Glover, Fabienne Stierli, Juanlo Catena, Melissa Carrillo, Sina Hartmann, Hans‐Peter Seidel, Matthias Mulder, Thomas Mason, Yasushi Kondo, Maximillian Wranik, Martin Appleby, Christoph Sager, Raymond Sierra, Gregory Gate, Pamela Schleissner, Xinxin Cheng, Tobias Weinert, Robert Cheng, Sandra Mous, John H. Beale, Michal Kepa, Amadeu Llebaria, Michael Hennig, Xavier Rovira, Joerg Standfuss   +29 more
wiley   +1 more source

Photochromic Cholesteric Liquid Crystals via Arylazopyrazole Functionalization of Hydroxypropyl Cellulose. [PDF]

Adv Mater
Fine SG, Hildenhagen N, Linke WR, Hansen MR, Ravoo BJ, Chazot CAC.   +5 more
europepmc   +1 more source

All-visible-light-responsive porous aromatic frameworks manipulate CO₂ uptake by reversible bulk isomerization of azobenzene pendants. [PDF]

Proc Natl Acad Sci U S A
Sheng J, Perego J, Bracco S, Cieciórski P, Danowski W, Comotti A, Feringa BL.   +6 more
europepmc   +1 more source

Recent Advances of Azobenzene-Based Photoresponsive Molecular Switches for Protein-Targeted Photopharmacology. [PDF]

Molecules
Jiang J, Yuan X, Hu L.
europepmc   +1 more source

Single-engineered-residue solvation perturbations regulate global protein architecture and function. [PDF]

Nat Commun
Liu Y, Zhai J, Cao S, Guo H, Zhang H, Song B, Guo J, Men D, He X, Li D.   +9 more
europepmc   +1 more source

Substituent Effects Govern the Efficiency of Isoxazole Photoisomerization to Carbonyl‑2<i>H</i>‑Azirines. [PDF]

ACS Org Inorg Au
Jackson KE, Szeto I, Seebald LM, Shepard SG.   +3 more
europepmc   +1 more source

Isomerization of spiropyran photoswitches in microphase-separated block copolymers. [PDF]

Sci Technol Adv Mater
Imato K, Momota K, Imae I, Hirai T, Ooyama Y.   +4 more
europepmc   +1 more source

Near-infrared-to-deep-blue photon upconversion engineered from PbS quantum dots and perylene derivatives. [PDF]

Chem Sci
Li H, Luan Q, Zhang S, Xi L, Feng Y, Hou L.   +5 more
europepmc   +1 more source

Acid- and Nucleophile-Gated Photoisomerization of Phosphaindirubin. [PDF]

Angew Chem Int Ed Engl
van der Wal JJ, Steen JD, Rückert AK, Peshkov RY, Hilbers MF, Prins PT, Buma WJ, Orthaber A, Crespi S.   +8 more
europepmc   +1 more source

Photo-Modulated Proton Transport in Merocyanine Metastable-State Photoacid Based Polymers. [PDF]

Small
Pacella G, Kim M, Hannah R, Chiechi RC, Faraji S, Portale G.   +5 more
europepmc   +1 more source