Results 201 to 210 of about 240,809 (322)

Aquaporin‐1, aquaporin‐3 and aquaporin‐5 differentially modulate cell biophysical and biomechanical properties, impacting cell stiffness and cell–cell adhesion

open access: yesThe FEBS Journal, EarlyView.
GA text Overexpression of aquaporins AQP1, AQP3, or AQP5 in HEK‐293 T cells induced changes in cell biophysical properties and migration. Atomic force microscopy (AFM)–based force spectroscopy studies demonstrated that AQP1 overexpression increased cell stiffness and cell–cell adhesion, AQP3 augmented cell stiffness but reduced cell–cell adhesion ...
Catarina Pimpão   +5 more
wiley   +1 more source

The fc fragment of IgMs binds C1q to activate the first step of the classical complement pathway, while inhibiting complement‐dependent cytotoxicity

open access: yesThe FEBS Journal, EarlyView.
Multimeric IgM‐fragment crystallizable region (Fc) fragments retain the ability to bind C1q and initiate the classical complement pathway, leading to C4 activation and deposition in vitro. However, the Fc cores can also inhibit complement‐dependent cytotoxicity by competing with surface‐bound antibodies for C1q engagement.
Andrea J. Pinto   +9 more
wiley   +1 more source

Moderate increase of MET in hepatocytes protects against cholestatic liver injury by promoting an effective antioxidant response

open access: yesThe FEBS Journal, EarlyView.
Moderate overexpression of wild‐type Met in hepatocytes (Alb‐R26Met mouse model) boosts a strong antioxidant response dependent on the glutathione system while impairing TGF‐β signaling in the liver. This leads to improved liver regeneration and protects against DDC‐induced injury, a model for cholestatic disease sharing features with primary ...
Carlos González‐Corralejo   +16 more
wiley   +1 more source

Inflammatory and Myocardial Biomarker Response Following Pulmonary Vein Isolation: Cryoballoon Versus Balloon‐in‐Basket Pulsed Field Ablation

open access: yesJournal of Cardiovascular Electrophysiology, EarlyView.
ABSTRACT Background Cryoballoon ablation (CB) is a well‐established thermal technique for pulmonary vein isolation (PVI), while balloon‐in‐basket pulsed field ablation (BiB‐PFA) represents a novel non‐thermal alternative. Both single‐shot systems may trigger systemic inflammation and myocardial injury, yet direct comparisons are lacking.
Jan‐Per Wenzel   +9 more
wiley   +1 more source

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