Results 221 to 230 of about 50,030 (271)

The G protein‐coupled receptor GPR89A is a novel potential therapeutic target to overcome cisplatin resistance in NSCLC Calu1 cells

open access: yesThe FEBS Journal, EarlyView.
A genome‐wide CRISPR‐Cas9‐based genetic screen in cisplatin‐resistant NSCLC cells revealed 63 potential candidate genes for overcoming cisplatin resistance, including GPR89A. GPR89A, localised in the Golgi, modulates voltage‐gated anion channel activity and is involved in intracellular pH reduction.
Hale Guler Kara   +9 more
wiley   +1 more source

Effect of light‐cured pulp capping materials on human dental pulp cells in vitro

open access: yesInternational Endodontic Journal, EarlyView.
Abstract Aim Gold standard as material in vital pulp therapy (VPT) is hydraulic calcium silicate cements (HCSC). To circumvent their prolonged setting time, light‐cured pulp capping materials containing calcium silicate or calcium hydroxide powder are available.
Laurentia Schuster   +3 more
wiley   +1 more source

A Personalized 4D Workflow for the Manufacturing of Functional and Removable Esthetic Devices: A Technical Report

open access: yesJournal of Esthetic and Restorative Dentistry, EarlyView.
ABSTRACT Objective This technical report describes a fully digital workflow for the manufacturing of a functional removable esthetic device (FRED) that addresses multiple clinical scenarios before prosthetic rehabilitation. The proposed method integrates advanced digital tools to achieve functional and esthetic outcomes while ensuring reversibility and
Mauro Merli   +6 more
wiley   +1 more source

Modulation of Sodium and Ammonia Transporters in the Context of Viral Gill Diseases in Common Carp (Cyprinus carpio)

open access: yesJournal of Fish Diseases, EarlyView.
ABSTRACT Osmoregulation and ammonia removal are among key physiological processes that take place in gills and affect fish homeostasis and well‐being. These processes can be disrupted by numerous environmental factors, but also by viral infections, especially those leading to severe gill disorders.
Maria Zawisza   +5 more
wiley   +1 more source

A comparison of super‐resolution microscopy techniques for imaging tightly packed microcolonies of an obligate intracellular bacterium

open access: yesJournal of Microscopy, EarlyView.
Abstract Conventional optical microscopy imaging of obligate intracellular bacteria is hampered by the small size of bacterial cells, tight clustering exhibited by some bacterial species and challenges relating to labelling such as background from host cells, a lack of validated reagents, and a lack of tools for genetic manipulation.
Alison J. North   +7 more
wiley   +1 more source

Model‐free machine learning‐based 3D single molecule localisation microscopy

open access: yesJournal of Microscopy, EarlyView.
Abstract Single molecule localisation microscopy (SMLM) can provide two‐dimensional super‐resolved image data from conventional fluorescence microscopes, while three dimensional (3D) SMLM usually involves a modification of the microscope, for example, to engineer a predictable axial variation in the point spread function.
Miguel A. Boland   +8 more
wiley   +1 more source

Neuroendocrine mechanisms responsible for elevated gonadotrophin‐releasing hormone and luteinising hormone pulses in polycystic ovary syndrome

open access: yesJournal of Neuroendocrinology, EarlyView.
Abstract Polycystic ovary syndrome (PCOS) is the leading cause of anovulatory infertility in premenopausal individuals with ovaries worldwide. Despite the diagnostic features of anovulation, ovarian cysts, and hyperandrogenemia, which indicate that ovary dysfunction is the cause of the syndrome, changes in central neuroendocrine circuits are a ...
Aleisha M. Moore
wiley   +1 more source

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