Results 71 to 80 of about 1,477 (175)

Iloperidone treatment mitigates the Juvenile Huntington's Disease phenotype possibly via Sigma‐1 Receptor Modulation

The FEBS Journal, EarlyView.
We investigated the potential of iloperidone as an activator of Sigma‐1 receptor (S1R) neuroprotective function in juvenile Huntington's disease (jHD). We tested iloperidone on cortical neurons differentiated from patient‐derived iPSCs, demonstrating that it acts as a S1R agonist, decreasing apoptosis, huntingtin aggregation, and oxidative stress ...
Ersilia Fornetti, Gaia Galluzzi, Mario Frezzini, Cécile Exertier, Vittorio Brufani, Gianni Colotti, Giancarlo Ruocco, Jessica Rosati, Angelo Luigi Vescovi, Daniele Narzi, Ilaria Genovese, Andrea Ilari   +11 more
wiley   +1 more source

FORECASTOR. I. Finding Optics Requirements and Exposure Times for the Cosmological Advanced Survey Telescope for Optical and UV Research Mission

The Astronomical Journal
The Cosmological Advanced Survey Telescope for Optical and ultraviolet Research (CASTOR) is a proposed Canadian-led 1 m class space telescope that will carry out ultraviolet and blue optical wide-field imaging, spectroscopy, and photometry.
Isaac Cheng, Tyrone E. Woods, Patrick Côté, Jennifer Glover, Dhananjhay Bansal, Melissa Amenouche, Madeline A. Marshall, Laurie Amen, John Hutchings, Laura Ferrarese, Kim A. Venn, Michael Balogh, Simon Blouin, Ryan Cloutier, Nolan Dickson, Sarah Gallagher, Martin Hellmich, Vincent Hénault-Brunet, Viraja Khatu, Cameron Lawlor-Forsyth, Cameron Morgan, Harvey Richer, Marcin Sawicki, Robert Sorba   +23 more
doaj   +1 more source

Impact of optical aberrations on axial position determination by photometry

Nature Methods, 2018
ImPhys/Imaging ...
Rasmus Ø. Thorsen, Christiaan N. Hulleman, Mathias Hammer, David Grünwald, Sjoerd Stallinga, Bernd Rieger   +5 more
openaire   +6 more sources

Long‐read sequencing‐based atlas of tissue‐specific expression of DNM1L transcript variants

The FEBS Journal, EarlyView.
Targeted long‐read sequencing resolves full‐length DNM1L (Drp1) isoforms and reveals conserved, tissue‐specific expression patterns across human and mouse tissues. Functional assays show that Drp1 isoforms differ in their ability to drive mitochondrial fission, independent of abundance, with specific exons modulating activity.
Feng Yan, Jafar S. Jabbari, Naomi X. L. Ling, Anne M. Kong, Jia Q. Truong, Marnie L. Maddock, Ayeshah A. Rosdah, Christopher G. Langendorf, Lifang Zhang, Jarmon G. Lees, Sebastian Bass‐Stringer, Danise Ann Onda, Alice Pébay, Mirella Dottori, Kim Loh, Jessica K. Holien, Sean Lal, Nadia M. Davidson, Jonathan S. Oakhill, Shiang Y. Lim   +19 more
wiley   +1 more source

Keck and Hubble Observations Show that MOA-2008-BLG-379Lb is a Super-Jupiter Orbiting an M Dwarf

The Astronomical Journal
We present high angular resolution imaging that detects the MOA-2008-BLG-379L exoplanet host star using Keck adaptive optics and the Hubble Space Telescope.
David P. Bennett, Aparna Bhattacharya, Jean-Philippe Beaulieu, Naoki Koshimoto, Joshua W. Blackman, Ian A. Bond, Clément Ranc, Natalia Rektsini, Sean K. Terry, Aikaterini Vandorou, Jessica R. Lu, Jean Baptiste Marquette, Greg Olmschenk, Daisuke Suzuki   +13 more
doaj   +1 more source

Experimental Study of PWM-Controlled Emission From a Large-Aperture VCSEL

IEEE Photonics Journal
This study demonstrates the use of pulse-width modulation (PWM) for mode selection in a large-aperture vertical-cavity surface-emitting laser (VCSEL). Experimental results reveal that driving the device with 1 kHz PWM pulses maintains a stable far-field ...
Miroslav Slouka, Dalibor Javurek, Erik Hendrych, Marcel Stofik, Martin Kutac, Jan Latal   +5 more
doaj   +1 more source

Unraveling the active site cover of coproheme decarboxylase from Listeria monocytogenes

The FEBS Journal, EarlyView.
During heme biosynthesis in Gram‐positive bacteria, coproheme decarboxylase (ChdC) catalyzes the conversion of four‐propionate substrate coproheme to the two propionate product heme b. Its active site is universally covered by a flexible linking loop. This study identifies an important histidine residue, which stabilizes the loop in a ChdC homolog.
Nikolaus Falb, Dominik Hörtnagel, Chris Oostenbrink, Paul G. Furtmüller, Stefan Hofbauer   +4 more
wiley   +1 more source

Probing Disk Ice Content and Polycyclic Aromatic Hydrocarbon Emission through Multiband MagAO+Clio Images of HD 141569

The Astrophysical Journal
We present resolved images of the inner disk component around HD 141569A using the Magellan adaptive optics system with the Clio2 1–5 μ m camera, offering a glimpse of a complex system thought to be in a short evolutionary phase between protoplanetary ...
Jay K. Kueny, Alycia J. Weinberger, Jared R. Males, Katie M. Morzinski, Laird M. Close, Katherine B. Follette, Philip M. Hinz   +6 more
doaj   +1 more source

Data-calibrated point spread function prediction

Astronomy & Astrophysics
Context. Precise knowledge of the point spread function (PSF) underpins many data analysis steps in astronomy, from photometry and astrometry to source de-blending and deconvolution.
Kuznetsov Arseniy, Neichel Benoit, Oberti Sylvain, Fusco Thierry   +3 more
doaj   +1 more source

Performance of Automated Hematology Analyzer Criteria in Detecting Peripheral Blood Smear Abnormalities: A Systematic Literature Review

International Journal of Laboratory Hematology, EarlyView.
ABSTRACT Objectives Criteria for visual examination of stained peripheral blood smear (PBS) differ among institutions in the United States and internationally. In an effort to standardize review criteria, the International Consensus Group for Hematology Review (ICGHR) proposed in 2005 a consensus list of rules for CBC findings that should trigger a ...
Elizabeth L. Courville, Michelle Grant, Emily Mason, Xueyan Chen, Giuseppe d'Onofrio, Ben Hedley, John L. Frater, Madhu M. Ouseph, Gina Zini, Stefanie McFadden, Jin‐Yeong Han, Cara Shirai, Amrom Obstfeld, Lauren H. Yaeger, Olga Pozdnyakova   +14 more
wiley   +1 more source