Results 21 to 30 of about 7,517 (258)

Application of Photodynamic Therapy with 5-Aminolevulinic Acid to Extracorporeal Photopheresis in the Treatment of Patients with Chronic Graft-versus-Host Disease: A First-in-Human Study

Pharmaceutics, 2021
Extracorporeal photopheresis (ECP), an immunomodulatory therapy for the treatment of chronic graft-versus-host disease (cGvHD), exposes isolated white blood cells to photoactivatable 8-methoxypsoralen (8-MOP) and UVA light to induce the apoptosis of T ...
Eidi Christensen, Olav A. Foss, Petter Quist-Paulsen, Ingrid Staur, Frode Pettersen, Toril Holien, Petras Juzenas, Qian Peng   +7 more
doaj   +1 more source

Extracorporeal photopheresis as an immunomodulatory treatment modality for chronic GvHD and the importance of emerging biomarkers

Frontiers in Immunology, 2023
Haematopoietic stem cell transplantation (HSCT) is the treatment of choice for malignant haematological diseases. Despite continuous improvements in pre- and post-transplantation procedures, the applicability of allo-HSCT is limited by life-threatening ...
I. Bojanić, N. Worel, Carolina P. Pacini, G. Stary, A. Piekarska, A. Flinn, Kimberly J. Schell, A. Gennery, R. Knobler, J. Lacerda, H. Greinix, D. Pulanić, R. Crossland   +12 more
semanticscholar   +1 more source

Boost of innate immunity cytokines as biomarkers of response to extracorporeal photopheresis in leukaemic cutaneous T-cell lymphoma patients.

British Journal of Dermatology, 2023
BACKGROUND Extracorporeal photopheresis (ECP) has emerged as a systemic first-line immunomodulatory therapy in leukaemic cutaneous T-cell lymphoma (L-CTCL) and now beginning to be utilized in other T-cell-mediated diseases. Although ECP has been used for
Y. Tsai, T. Schlaepfer, D. Ignatova, Yun-Tsan Chang, A. Valaperti, Boyko Amarov, G. Blanchard, K. Pehr, Maya Vonow-Eisenring, Mirjana Urosevic-Maiwald, W. Hoetzenecker, S. Pascolo, C. Iselin, C. Fassnacht, F. Dimitriou, M. Bobrowicz, E. Guenova   +16 more
semanticscholar   +1 more source

The effect of UVA light/8-methoxypsoralen exposure used in Extracorporeal Photopheresis treatment on platelets and extracellular vesicles

bioRxiv, 2023
Extracorporeal Photopheresis (ECP) is a leukapheresis based treatment for Cutaneous T-Cell Lymphoma, which takes advantage of the cellular lethal effects of UVA light in combination with a photoactivated drug, 8-methoxypsoralen.
H. Macleod, L. Weiss, S. Kelliher, B. Kevane, F. N. Ní Áinle, Patricia B Maguire   +5 more
semanticscholar   +1 more source

Mogamulizumab Multimodality Therapy with Systemic Retinoids, Interferon, or Extracorporeal Photopheresis for Advanced Cutaneous T-Cell Lymphoma

Dermatologic Therapy, 2023
Mogamulizumab is a novel monoclonal antibody designed to target CC chemokine receptor 4 (CCR4), which is expressed by tumor cells in cutaneous T-cell lymphoma (CTCL).
David M. Weiner, Supriya Rastogi, Daniel J. Lewis, Leah Cohen, Sara Choi, C. Vittorio, P. Haun, Sara S. Samimi, J. Villaseñor‐Park, R. Bhansali, E. Chong, D. Landsburg, S. Nasta, S. Schuster, J. Svoboda, Ellen J. Kim, A. Rook, Stefan K. Barta   +17 more
semanticscholar   +1 more source

Enhancement of antibody-dependent cellular cytotoxicity is associated with treatment response to extracorporeal photopheresis in Sézary syndrome [PDF]

, 2021
Sézary syndrome (SS) is a rare, leukemic type of cutaneous T-cell lymphoma (CTCL), for which extracorporeal photopheresis (ECP) is a first-line therapy. Reliable biomarkers to objectively monitor the response to ECP in patients with SS are missing.
Bobrowicz, Malgorzata, Chang, Yun-Tsan, Dimitriou, Florentia, Fassnacht, Christina, Guenova, Emmanuella, Hoetzenecker, Wolfram, Iselin, Christoph, Nägeli, Mirjam, Pascolo, Steve, Schlaepfer, Tanja   +9 more
core   +4 more sources

Effects of Extracorporeal Photopheresis on Quality of Life and the Course of Diseases in Patients With Mycosis Fungoides and Graft-Versus-Host Disease: A Single-Center Analysis

Cureus, 2023
Introduction: The aim of the study was to systematically analyze the influence of extracorporeal photopheresis (ECP) on the quality of life (LQ) and the course of the disease in patients with Mycosis Fungoides (MF), as well as with Graft-versus-Host ...
Romanos Vogiatzis, W. Krüger, M. Jünger, A. Arnold   +3 more
semanticscholar   +1 more source

What Does the Future Hold for Biomarkers of Response to Extracorporeal Photopheresis for Mycosis Fungoides and Sézary Syndrome?

Cells, 2023
Extracorporeal photopheresis (ECP) is an FDA-approved immunotherapy for cutaneous T-cell lymphoma, which can provide a complete response in some patients. However, it is still being determined who will respond well, and predictive biomarkers are urgently
O. Akilov
semanticscholar   +1 more source

EXTRACORPOREAL PHOTOCHEMOTHERAPY IN PSORIASIS AND PSORIATIC ARTHRITIS

Alʹmanah Kliničeskoj Mediciny, 2016
Background: Psoriasis is the most prevalent chronic dermatosis of an autoimmune origin that is characterized by increasing incidence of both severe clinical forms and complications, the most threatening of which is psoriatic arthritis.
E. S. Yakubovskaya, V. A. Molochkov, A. V. Kil'dyushevskiy, O. V. Karzanov   +3 more
doaj   +1 more source

CLINICAL EFFICACY OF EXTRA-CORPOREAL PHOTOCHEMOTHERAPY IN SYSTEMIC LUPUS ERYTHEMATOSUS

Alʹmanah Kliničeskoj Mediciny, 2016
Aim: To assess clinical efficacy of extracorporeal photochemotherapy in patients with systemic lupus erythematosus (SLE). Materials and methods: 30 SLE patients were thoroughly examined.
A. V. Molochkov, A. V. Kil’dyushevskiy, O. V. Karzanov, L. S. Bagapsh   +3 more
doaj   +1 more source