Results 101 to 110 of about 15,911 (308)

Multivariate Screening and Automated Clustering of Macrophage Immunoreactome to Nanoparticles and Photothermal Therapy

Advanced Science, EarlyView.
Predicting immune responses to treatments, including nanomedicines, with high throughput test is challenging due to the immunoreactome's complexity and plasticity. A predictive screening platform integrating pathway activation and gene profiling in macrophages has been developed as a versatile tool for designing effective immunotherapies.
Sonia Becharef, Léa Jabbour, Nassima Bekaddour, Giulio Avveduto, Nathalie Luciani, Gautier Laurent, Rana Bazzi, Edouard Alphandery, Stéphane Roux, Amanda K. A. Silva, Kelly Aubertin, Jean‐Philippe Herbeuval, Florence Gazeau   +12 more
wiley   +1 more source

Hypomorphic PCNA mutation underlies a novel human DNA repair disorder [PDF]

, 2014
A number of human disorders, including Cockayne syndrome, UV-sensitive syndrome, xeroderma pigmentosum and trichothiodystrophy, result from the mutation of genes encoding molecules important for nucleotide excision repair.
Baple, Emma L, Chambers, Helen, Chioza, Barry A, Coblentz, Roselyn, Crosby, Andrew H, Cross, Harold E, Fawcett, Heather, Green, Catherine M, Harlalka, Gaurav V, Jackson, Andrew P, Last, James I, Lehmann, Alan R, Mansour, Sahar, Muggenthaler, Martina, Nakazawa, Yuka, Ogi, Tomoo, Patton, Michael A, Rich, Phillip, Sreekantan-Nair, Ajith, Stein, Constance K, Taylor, A Malcolm R, Wagner, Karin   +21 more
core  

Advances in Microfluidic Cochlea‐On‐A‐Chip

Advanced Science, EarlyView.
This review systematically examines diverse cell sources for inner ear organoids and outlines stepwise induction protocols. Furthermore, it discusses current applications and prospective developments of cochlea‐on‐a‐chip technologies in areas such as deafness modeling, mechanistic studies, and drug evaluation, with particular focus on gene‐therapy drug
Tian Shen, Shanying Han, Weiwei He, Wen Yang, Xinghua Tang, Xiaolong Zhao, Xinghong Liu, Zhenhua Shao, Lin Cheng, Yu Zhao, Jiangang Fan   +10 more
wiley   +1 more source

IncRNA‐ZFAS1, an Emerging Gate‐Keeper in DNA Damage‐Dependent Transcriptional Regulation

Advanced Science, EarlyView.
LncZFAS1 plays a crucial role during DNA damage response in mammalian cells. Loss of lncZFAS1 results in deficient DNA lesion removal and reduced cell viability. Mechanistically, lncZFAS1 modulates RNAPII phosphorylation and transcription and thereby promotes both GG‐NER and TC‐NER upon UV damage.
Jiena Liu, Qing Lu, Zixuan Fan, Jiahui Lin, Nan He, Xin Zhang, Zhaoya Han, Tingting Zhu, Zhenzhen Wu, Yingying Xu, Yuming Wang   +10 more
wiley   +1 more source

Myositis-specific and myositis-associated autoantibody profiles and their clinical associations in a large series of patients with polymyositis and dermatomyositis

Clinics, 2013
OBJECTIVE: To analyze the prevalence of myositis-specific and myositis-associated autoantibodies and their clinical correlations in a large series of patients with dermatomyositis/polymyositis.
Marcela Gran Pina Cruellas, Vilma dos Santos Trindade Viana, Maurício Levy-Neto, Fernando Henrique Carlos de Souza, Samuel Katsuyuki Shinjo   +4 more
doaj   +1 more source

Minimally Invasive Chemical Biopsy Needle with Self‐Wettable Extraction Phase For In Vivo Tissue Sampling During Medical Procedures

Advanced Science, EarlyView.
A new tissue sampling device using an acupuncture needle with bio‐compatible extraction sorbents in the recessed section is developed. The coating material using self‐wettable particles doesn't require solvent activation after sterilization. This device is applied for the anti‐cancer drug concentration monitoring during the in vivo lung perfusion ...
Runshan Will Jiang, Wei Zhou, Marcelo Cypel, Todd L. Demmy, Gal Shafirstein, Guillermo Garza, Emily Gawrys, Joanna Bogusiewicz, Barbara Bojko, Janusz Pawliszyn   +9 more
wiley   +1 more source

Seven- and 23-year-old Siblings with Papulonodular Lesions after Sun Exposure: A Quiz

Acta Dermato-Venereologica, 2021
Davide Neri, Karola Maria Stieler, Annika Vogt, Kamran Ghoreschi, Ulrike Blume-Peytavi   +4 more
doaj   +1 more source

Ictal epileptic headache. an old story with courses and appeals [PDF]

, 2012
The term "ictal epileptic headache" has been recently proposed to classify the clinical picture in which headache is the isolated ictal symptom of a seizure.
MARTELLETTI, Paolo, NEGRO, ANDREA, PARISI, Pasquale, Pasquale Striano, Vincenzo Belcastro   +4 more
core   +1 more source

Generation of Neural Organoids and Their Application in Disease Modeling and Regenerative Medicine

Advanced Science, EarlyView.
Neural organoids provide a versatile platform for neurological research. Advances in organoid technology have partially achieved human neural tissue complexity in terms of tissue structure, cell diversity, and neural signaling, offering insights into neural disorders and regenerative strategies. Technology advances from biomaterials, bio‐manufacturing,
Ruiqi Huang, Feng Gao, Liqun Yu, Haokun Chen, Rongrong Zhu   +4 more
wiley   +1 more source

Formoterol dynamically alters endocannabinoid tone in the periaqueductal gray inducing headache

The Journal of Headache and Pain
Background Headache is a pain disorder present in populations world-wide with a higher incidence in females. Specifically, the incidences of medication overuse headache (MOH) have increased worldwide.
Ingrid L. Peterson, Erika Liktor-Busa, Kelly L. Karlage, Sally J. Young, Natalie E. Scholpa, Rick G. Schnellmann, Tally M. Largent-Milnes   +6 more
doaj   +1 more source