Results 51 to 60 of about 34,272 (324)

Quantification of cellular phototoxicity of organelle stains by the dynamics of microtubule polymerization

View
Being able to quantify the phototoxicity of dyes and drugs in live cells allows biologists to better understand cell responses to exogenous stimuli during imaging.
Shivam Mahapatra, Seohee Ma, Bin Dong, Chi Zhang   +3 more
doaj   +1 more source

Integrated ultrasonic particle positioning and low excitation light fluorescence imaging [PDF]

, 2013
A compact hybrid system has been developed to position and detect fluorescent micro-particles by combining a Single Photon Avalanche Diode (SPAD) imager with an acoustic manipulator. The detector comprises a SPAD array, light-emitting diode (LED), lenses,
Al-Rawhani, M., Beeley, J., Bernassau, A.L., Cumming, D.R.S.   +3 more
core   +2 more sources

Photoactivated Proximity Protein Labeling Reveals Enhanced Tumor Retention of a D‐Peptide‐Ruthenium Prodrug Conjugate

Advanced Healthcare Materials, EarlyView.
Six stereoisomeric ruthenium‐peptide conjugates were synthesized and characterized, which showed high potential in photoactivated chemotherapy (PACT) and proximity protein labeling. Abstract Amino acid chirality is known to influence the biological properties of peptide‐containing prodrugs.
Liyan Zhang, Peiyuan Wang, Hildert Bronkhorst, Yurii Husiev, Ludovic Bretin, Maarten N. van Ginkel, Wen Sun, Sylvestre Bonnet   +7 more
wiley   +1 more source

The blue light hazard and its use on the evaluation of photochemical risk for domestic lighting. An in vivo study

Environment International
Background: Nowadays artificial light highly increases human exposure to light leading to circadian rhythm and sleep perturbations. Moreover, excessive exposure of ocular structures to photons can induce irreversible retinal damage.
Anaïs Françon, Francine Behar-Cohen, Alicia Torriglia   +2 more
doaj   +1 more source

A highly soluble, non-phototoxic, non-fluorescent blebbistatin derivative [PDF]

, 2016
Blebbistatin is a commonly used molecular tool for the specific inhibition of various myosin II isoforms both in vitro and in vivo. Despite its popularity, the use of blebbistatin is hindered by its poor water-solubility (below 10 micromolar in aqueous ...
Hegyi, György, Horváth, István Ádám, Képiró, Miklós, Lenkei, Zsolt, Málnási-Csizmadia, András, Ráti, Szilvia, Varga, Máté, Várkuti, Boglárka, Végner, László, Zsigmond, Áron   +9 more
core   +1 more source

A Novel Microfluidic System for 3D Epidermis and Full‐Thickness Skin Growth for Nanoparticle Safety Assessment

Advanced Healthcare Materials, EarlyView.
This work presents a novel, dynamically perfused, configurable microfluidic system for epidermis‐only (E and full‐thickness skin (FT SoC) growth, emulating human skin structure and barrier function. Upon TiO2 nanoparticle exposure, the system reveals compromised barrier integrity, reduced metabolic activity, increased permeability, and chemokine‐driven
Samantha Costa, Ana B. Carneiro, Filipa Lebre, João Meneses, Alar Ainla, Cacilda Moura, Ernesto Alfaro‐Moreno, Ana R. Ribeiro   +7 more
wiley   +1 more source

Retinal phototoxicity after macular hole surgery in a patient under paclitaxel [PDF]

, 2023
José M. Ruiz‐Moreno, María García‐Zamora, Jorge Ruiz‐Medrano   +2 more
openalex   +1 more source

Phototoxicity of Lumidoxycycline

Journal of Investigative Dermatology, 1993
Doxycycline (DOTC) is a photosensitizing drug whose mechanism of phototoxicity is complicated by the large variety of stable photoproducts formed. To assess the role of a DOTC photoproduct, lumidoxycycline (LuDOTC), in the photosensitization mechanism of DOTC, MGH-U1 human bladder carcinoma cells were treated in vitro with either DOTC or LuDOTC, and ...
Shea, Christopher R, Olack, Gerard A, Morrison, Harry, Chen, Norah, Hasan, Tayyaba   +4 more
openaire   +2 more sources

Fluorescent Polymeric Nanofibers as Ratiometric Multiplexed Skin Sensors of pH and Oxygen

Advanced Healthcare Materials, EarlyView.
Fluorescent polymeric nanofibers and nanorods are produced as ratiometric sensors of two important physiological parameters: pH and oxygen. They operate by dual Forster resonance energy transfer from large number of energy donor dyes to limited number of two distinct energy acceptors, enabling simultaneous sensing of pH and oxygen.
Rémi Pelletier, Anila Hoskere Ashoka, Andrey S. Klymchenko   +2 more
wiley   +1 more source

Titanium Dioxide Induces Apoptosis under UVA Irradiation via the Generation of Lysosomal Membrane Permeabilization-Dependent Reactive Oxygen Species in HaCat Cells

Nanomaterials, 2021
Titanium dioxide nanoparticles (TiO2 NPs) have wide commercial applications, owing to their small size; however, the biosafety of TiO2 NPs should be evaluated further.
In Young Kim, Tae Geol Lee, Vytas Reipa, Min Beom Heo   +3 more
doaj   +1 more source