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The Multifaceted Legacy of Thalidomide: Chemistry and Biology Driving Modern Drug Design. [PDF]

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Nikovia K   +4 more
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Developmental toxicity evaluation of phthalic acid, one of the metabolites of phthalic acid esters, in rats

Toxicology Letters, 1997
The objective of this study was to evaluate the developmental toxicity of phthalic acid (PA), which is one of the metabolites of phthalic acid esters (PAEs). Pregnant rats were given PA at a dose of 0 (control), 1.25, 2.5, or 5.0% in the diet on day 7 through day 16 of pregnancy.
Akira Harazono   +2 more
exaly   +3 more sources

Phthalic Acid Esters

Food and Chemical Toxicology, 1984
The twentieth century can as properly be called the age of organic chemistry as it can the atomic age. The dramatic increase in the production of synthetic fibers, processed foods, pesticides, plastics, pharmaceuticals, and a thousand other materials has completely altered our immediate human environment and provided a wealth of new materials.
C. S. Giam   +3 more
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The diamagnetic susceptibilities of phthalic acid and phthalic anhydride

Proceedings of the Indian Academy of Sciences - Section A, 1949
1. The gram-molecular susceptibilities of carefully purified samples of phthalic acid and its anhydride are determined. The susceptibilities are: Phthalic acid, Xm=−81·24×10−6 Phthalic anhydride, Xm=−67·31×10−6 It is found that whereas the value of the gram-molecular susceptibility of phthalic acid found by Gray and Birse and ourselves is nearly ...
Bawa Kartar Singh   +3 more
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Toxicokinetics of Phthalic Acid: The Common Final Metabolite of Phthalic Acid Esters in Rats

Journal of Toxicology and Environmental Health, Part A, 2007
The toxicokinetic profiles of phthalic acid (PA), which is the common final metabolite of phthalic acid esters (PAE), were studied in rats after orally administering doses 20, 100, or 500 mg/kg. Concentrations of PA were determined in serum or urine by high-performance liquid chromatography (HPLC). The plasma concentrations of PA showed a biexponential
Duck Soo, Lim   +6 more
openaire   +2 more sources

Aqueous solubility of m-phthalic acid, o-phthalic acid and p-phthalic acid from 298 to 483 K

Separation and Purification Technology, 1999
Abstract In an equilibrium cell, the aqueous solubility of m -phthalic acid ( m -PTA), o -phthalic acid ( o -PTA), p -phthalic acid ( p -PTA) was determined from 298 to 483 K using a method in which an excess amount of solubilizate was equilibrated with the aqueous solution and the saturated liquid compositions were analyzed by titration.
Nanyin Han   +3 more
openaire   +1 more source

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