Results 141 to 150 of about 522,256 (296)
Advanced Science, EarlyView.EasyAmplicon 2 is an updated, user‐friendly, and community‐supported pipeline designed for full‐length amplicon data from long‐read sequencing technologies such as PacBio and Nanopore. It supports multiple platforms (Illumina, PacBio, Nanopore, etc.), integrates tools like DADA2 and Emu, and offers a complete workflow from raw data processing to high ...
Hao Luo +24 more
wiley +1 more source
Distinct Phage‐Encoded Enzymes for Substitution of Deoxythymidine by Deoxyuridine in Phage Genomes
Advanced Science, EarlyView.Distinct enzymes including dCTP deaminases (Dcds), dTMP phosphatases (Dtms), and dTTP pyrophosphatases (Dtt) are found to be responsible for dU‐DNA biosynthesis in the phages PBS1, DSS3_VP1, and PhiR1‐37. Both PhiR1‐37‐derived and synthetic dU‐DNA are resistant to cleavage by restriction enzymes and Cas12a nuclease targeting dT‐containing sites.
Yating Li +7 more
wiley +1 more source
ON A NEW TYPE OF FERN-STELE, AND ITS PROBABLE PHYLOGENETIC RELATIONS
, 1902 A. G. Tansley, R. B. J. LULHAM
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Dual Disruption of the Immune Cytokine Spätzle Facilitates Fungal Infection of Diverse Insect Hosts
Advanced Science, EarlyView.The Toll pathway is essential for insect defense against fungal pathogens. This works reports that fungal parasites employ two divergent virulent effectors to target the Toll receptor ligand Spätzle: a metalloprotease degrading it and a hairpin‐like effector hijacking it to block signal transduction. This dual strategy enables the fungus to kill a wide
Shuangxiu Song +7 more
wiley +1 more source
Advanced Science, EarlyView.ARID1A is frequently mutated in both non‐malignant tissues and cancers, but its role in tumor development after exposure to genotoxic carcinogen remains unclear. It is found that aristolochic acid I accelerated liver tumorigenesis in ARID1A‐deficient context by impairing nucleotide excision repair and enhancing carcinogen bioactivation, revealing key ...
Lan Wang +8 more
wiley +1 more source
Insect I‐Type Lysozymes Function as Antiviral Proteases by Forming Biomolecular Condensates
Advanced Science, EarlyView.Upon rice viral infection, the insect vector activates the Toll–MyD88–Dorsal signaling cascade, inducing i‐type lysozyme (Lyz‐I1) expression. Lyz‐I1 functions as an antiviral protease through its conserved catalytic dyad Glu/Asp (E/D), mediating cleavage of viral proteins at specific Lys (K) residues.
Yu Du +5 more
wiley +1 more source
III. On the phylogenetic significance of the wing‐markings in certain genera of the Nymphalidæ.
, 1890 F. A. Dixey
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Molecular epidemiology and phylogenetic analysis of Dengue virus type-1 and 2 isolated in Malaysia [PDF]
, 1969 Muhd Hasyim Chew +2 more
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