Results 141 to 150 of about 855,866 (324)

AI‐Driven De Novo Design of Ultra Long‐Acting GLP‐1 Receptor Agonists

Advanced Science, EarlyView.
De novo GLP‐1RAs can be computationally designed to exhibit extended half‐life and superior efficacy compared to Semaglutide. Abstract Peptide drugs have revolutionized modern therapeutics, offering novel treatment avenues for various diseases. Nevertheless, low design efficacy, time consumption, and high cost still hinder peptide drug design and ...
Ting Wei, Jiating Ma, Xiaochen Cui, Jiahui Lin, Zhuoqi Zheng, Liu Cheng, Taiying Cui, Xiaoqian Lin, Junjie Zhu, Xuyang Ran, Xiaokun Hong, Luke Johnston, Zhangsheng Yu, Haifeng Chen   +13 more
wiley   +1 more source

Long Non‐Coding RNA IGFRIL Couples with PTBP1 to Destabilize IGFBP3 mRNA to Promote the IGF1R‐AKT‐mTOR Axis and Hepatocellular Carcinoma

Advanced Science, EarlyView.
The limited understanding of IGFR pathway activation hinders its clinical application in HCC. Here, IGFRIL is identified as a novel non‐coding activator of the IGF1R, which recruits PTBP1 to destabilize IGFBP3 mRNA and activates IGF1R, and proposes IGFRIL as a novel actionable target for HCC patients.
Jing Zhang, Chengming Gao, Haibei Li, Yuying Chen, Liting Yang, Qian Jin, Lan Feng, Xia Wang, Xinyi Liu, Hongxia Chen, Rong Ye, Yuanchao Xue, Huiyun Wang, Musheng Zeng, Ming Yang, Huaiqiang Ju, Chengzhi Gao, Guangming Zhou, Qi Zhang, Qian Zhang, Geng Qin, Yuanfeng Li, Yahui Wang, Aiqing Yang, Anfeng Si, Qingfeng Song, Fuchu He, Pengbo Cao, Gangqiao Zhou   +28 more
wiley   +1 more source

A Phylogenetic Analysis and Classification of Recent Dabbling Ducks (Tribe Anatini) Based on Comparative Morphology [PDF]

, 1991
Bradley C. Livezey
openalex   +1 more source

Protein Spatial Structure Meets Artificial Intelligence: Revolutionizing Drug Synergy–Antagonism in Precision Medicine

Advanced Science, EarlyView.
This review comprehensively examines the applications of protein three‐dimensional structures and artificial intelligence in investigating drug synergistic and antagonistic effects. The research findings provide compelling evidence for the precision treatment of cancer and metabolic diseases, thereby promoting the development of personalized medicine ...
Anqi Lin, Chang Che, Aimin Jiang, Chang Qi, Antonino Glaviano, Zhijie Zhao, Zhirou Zhang, Zaoqu Liu, Ziyao Zhou, Quan Cheng, Shuofeng Yuan, Peng Luo   +11 more
wiley   +1 more source

Genetic variability of grapevine Pinot gris virus (GPGV) in an organically cultivated vineyard in Hungary

Phytopathologia Mediterranea
Grapevine Pinot gris virus (GPGV) is a recently identified trichovirus infecting grapevines. Despite wide distribution, there is limited available information on epidemiology, transmission, and associated symptoms of grapevine leaf mottling and ...
Réka SÁRAY, Erzsébet SZATHMÁRY, Dóra PINCZÉS, Asztéria ALMÁSI, Tamás DEÁK, László PALKOVICS, Katalin SALÁNKI   +6 more
doaj   +1 more source

An Analysis of Hair Structure and Its Phylogenetic Implications among Heteromyid Rodents

, 1978
J. A. Homan, Hugh H. Genoways
openalex   +2 more sources

Spatiotemporal Transcriptomic Atlas Reveals the Regulatory Mechanisms Underlying Early Inflorescence Development and Sex Differentiation in Spinach

Advanced Science, EarlyView.
High‐resolution spatiotemporal transcriptomic data from male and female spinach inflorescences across four key stages first reveal the sex differentiation initiates at the four‐leaf stage and is governed by epigenetic regulation via the SpMSI1‐SpHDT2 complex.
Chen You, Hao Yang, Yueyan Zhao, Xiaoning Wang, Shuaijie Wei, Ning Chen, Yulan Zhang, Luxian Liu, Wei Qian, Shufen Li, Wujun Gao   +10 more
wiley   +1 more source

Molecular Phylogenetic Analysis: Design and Implementation of Scalable and Reliable Algorithms and Verification of Phylogenetic Properties

, 1970
Jorge Álvarez-Jarreta, Gregorio de Miguel Casado, Elvira Mayordomo   +2 more
openalex   +2 more sources

Phylogenetic analysis supports horizontal transfer of P transposable elements. [PDF]

, 1994
Jonathan B. Clark, Wayne P. Maddison, Margaret G. Kidwell   +2 more
openalex   +1 more source

Enhancing the β‐Oxidation‐Like Pathway for the Optimal Production of the Immunosuppressant Mycophenolic Acid

Advanced Science, EarlyView.
The most elaborate known example of β‐oxidation‐like pathway recruitment in fungi is reported, involving a 10‐step oxidative chain‐shortening cascade catalyzed by five dedicated enzymes to generate the pharmacophore of mycophenolic acid (MPA)—a novel clinical immunosuppressant. Our findings illustrate how nature repurposes catabolic enzymes for complex
Baoqiang Fan, Yinuo Liu, Lu‐ping Chi, Chaofan Yang, Shengying Li, Wei Zhang   +5 more
wiley   +1 more source