Results 161 to 170 of about 6,848,180 (327)

Alphaviral Capsid Proteins Inhibit Stress Granule Assembly via Competitive RNA Binding With G3BP1

Advanced Science, EarlyView.
Stress granules exert antiviral functions. This study illustrates a conserved function of alphaviral capsid proteins in modulating stress granules. Oligomerization mediated by a helical motif coupled with a positively charged intrinsically disordered region (IDR) directly competes with G3BP1 for RNA binding, thereby disrupting G3BP1‐RNA liquid–liquid ...
Yun Zhang, Yi Liu, Zhiying Yao, Haolong Lai, Xiaoxin Chen, Ziqiu Wang, Yiqiong Bao, Tingting Li, Xiaoming Zhou, Xiabin Chen, Peiguo Yang   +10 more
wiley   +1 more source

A Reactive Antagonist Strategy: Cysteine‐Directed Covalent Molecular Glue in Plant Hormone Receptor Regulation

Advanced Science, EarlyView.
The plant hormone jasmonate is perceived by COI1‐JAZ co‐receptors comprising a single F‐box protein COI1 and multiple JAZ repressors with overlapping functions, complicating genetic analysis. We present a reactive antagonist (RA) strategy that selectively promotes COI1 binding to a cysteine‐engineered JAZ variant while blocking wild‐type JAZs, enabling
Minoru Ueda, Kotaro Matsumoto, Takao Nomura, Yousuke Takaoka, Taichi Okumura, Wataru Kozaki, Hikaru Hoshikawa, Yuho Nishizato, Andrea Chini, Roberto Solano, Katsumi Maenaka   +10 more
wiley   +1 more source

Transmission network of Hepatitis C virus subtype 2a in Huazhou County, Shaanxi Province, China

BMC Infectious Diseases
Background Huazhou County has one of the highest rates of hepatitis C virus (HCV) infection incidence and prevalence in Shaanxi Province, northwest China.
Mengyan Zhang, Shaoqi Ning, Luqian Zhang, Gang Liu, Sa Chen, Yi Zhang   +5 more
doaj   +1 more source

Multidimensionality of tree communities structure host-parasitoid networks and their phylogenetic composition

eLife
Environmental factors can influence ecological networks, but these effects are poorly understood in the realm of the phylogeny of host-parasitoid interactions.
Ming-Qiang Wang, Shi-Kun Guo, Peng-Fei Guo, Juan-Juan Yang, Guo-Ai Chen, Douglas Chesters, Michael C Orr, Ze-Qing Niu, Michael Staab, Jing-Ting Chen, Yi Li, Qing-Song Zhou, Felix Fornoff, Xiaoyu Shi, Shan Li, Massimo Martini, Alexandra-Maria Klein, Andreas Schuldt, Xiaojuan Liu, Keping Ma, Helge Bruelheide, Arong Luo, Chao-Dong Zhu   +22 more
doaj   +1 more source

An exploration of alternative visualisations of the basic helix-loop-helix protein interaction network

BMC Bioinformatics, 2007
Background Alternative representations of biochemical networks emphasise different aspects of the data and contribute to the understanding of complex biological systems.
Amoutzias Grigoris D, Lovell Simon C, Pinney John W, Holden Brian J, Robertson David L   +4 more
doaj   +1 more source

NetRAX: accurate and fast maximum likelihood phylogenetic network inference. [PDF]

Bioinformatics, 2022
Lutteropp S, Scornavacca C, Kozlov AM, Morel B, Stamatakis A.   +4 more
europepmc   +1 more source

PhyloNetworks: A Package for Phylogenetic Networks

Molecular Biology and Evolution, 2017
PhyloNetworks is a Julia package for the inference, manipulation, visualization, and use of phylogenetic networks in an interactive environment. Inference of phylogenetic networks is done with maximum pseudolikelihood from gene trees or multi-locus sequences (SNaQ), with possible bootstrap analysis.
Solís-Lemus, Claudia, Bastide, Paul, Ané, Céline   +2 more
openaire   +3 more sources

Nanoparticle Immunoadjuvant Complexes Augment Germinal Center Responses to Vaccination

Advanced Science, EarlyView.
Scaffolding IL‐21 on the surface of a self‐assembling nanoparticle immunogen drives improved germinal center and humoral immune responses. These nanoparticle immunoadjuvant complexes (NICs) functionally modulate the germinal center driving improved somatic hypermutation and antibody maturation, suggesting this platform has potential utility as a ...
Nicholas J. Tursi, Colby J. Agostino, Jinwei Huang, Toshitha Kannan, Niklas Laenger, Jennifer Londregan, Katlyn Lederer, Michaela Helble, Nicole Bedanova, Cory Livingston, Ebony N. Gary, Madison McCanna, Marta Tarquis Medina, Rumi Habib, Ignacio Rodriguez Relaño, Ivan Maillard, Ami Patel, David Allman, Andrew Kossenkov, Amelia Escolano, Daniel W. Kulp, David. B. Weiner   +21 more
wiley   +1 more source

Occurrence of Thelazia callipaeda and its vector Phortica variegata in Austria and South Tyrol, Italy, and a global comparison by phylogenetic network analysis. [PDF]

Parasit Vectors, 2023
Unterköfler MS, Dengg P, Niederbacher M, Lindorfer S, Eberle A, Huck A, Staufer K, Zittra C, Wortha LN, Hodžić A, Duscher GG, Harl J, Schlüsslmayr G, Bezerra-Santos MA, Otranto D, Silbermayr K, Fuehrer HP.   +16 more
europepmc   +1 more source

Phylogenetic structure of European Salmonella Enteritidis outbreak correlates with national and international egg distribution network

Microbial Genomics, 2016
Outbreaks of Salmonella Enteritidis have long been associated with contaminated poultry and eggs. In the summer of 2014 a large multi-national outbreak of Salmonella Enteritidis phage type 14b occurred with over 350 cases reported in the United Kingdom ...
T. Dallman, T. Inns, T. Jombart, P. Ashton, N. Loman, C. Chatt, Ute Messelhaeusser, W. Rabsch, S. Simon, S. Nikisins, H. Bernard, S. le Hello, Nathalie Jourdan da-Silva, C. Kornschober, J. Mossong, P. Hawkey, E. D. de Pinna, K. Grant, P. Cleary   +18 more
semanticscholar   +1 more source