Results 91 to 100 of about 7,737,899 (379)

Engineering of an Ancestral McbA with Enhanced Domain Mobility Extends Biocatalytic Amide Synthesis Scope

Advanced Synthesis &Catalysis, EarlyView.
We show how engineered ancestral amide bond synthetases (ABSs) together with cofactor recycling using a single polyphosphate kinase paves the way for chemoenzymatic synthesis of pharmacophores. The figure illustrates how ancestral ABS has a more flexible C‐terminal domain, which is associated with enhanced catalytic performance and expanded amine scope.
Elisabeth Söderberg, Marianne R. Molenaar, Katarzyna Zaczyk, Magnus Johansson, Martin A. Hayes, Per‐Olof Syrén   +5 more
wiley   +1 more source

The complete mitochondrial genome of Thryssa setirostris (Engraulinae, Engranlidae, Clupeoidei) and phylogenetic studies of Clupeoidei

Mitochondrial DNA. Part B. Resources, 2018
The complete mitochondrial genome of Thryssa setirostris has been determined. The whole sequence was 16,926 bp in length and included 13 protein-coding genes, 22 transfer RNA genes, 2 ribosomal RNA genes, and 1 control region (D-loop).
Wei Chen, Hui Jiang, Xun Du, Li Gong, Liqing Liu, Bingjian Liu, Zhenming Lü   +6 more
doaj   +1 more source

Genome-wide signatures of convergent evolution in echolocating mammals [PDF]

, 2013
Evolution is typically thought to proceed through divergence of genes, proteins, and ultimately phenotypes(1-3). However, similar traits might also evolve convergently in unrelated taxa due to similar selection pressures(4,5).
A Schneider, A Stamatakis, A Stamatakis, A Terrinoni, AF Ryan, AG Clark, AJ Drummond, AM Hancock, BP Lewis, EB Kim, EC Teeling, EC Teeling, Elia Stupka, G Jones, G Jones, G Li, G Parra, G Parra, G Zhang, Georgia Tsagkogeorga, HB Zhao, HB Zhao, J Castresana, James A. Cotton, JF Hughes, JI Fasick, Joe Parker, JP Bielawski, JZ Zhang, K Katoh, K Kriener, K Lindblad-Toh, KG Becker, KTJ Davies, M Kanehisa, M Soskine, M Vater, N Lartillot, OR Bininda-Emonds, Paolo Provero, PR Grant, R Li, R She, RC Edgar, RR Hoy, Stephen J. Rossiter, T Junier, TA Castoe, TSK Prasad, V Ranwez, W Huang da, WJ Murphy, WM Fitch, WS Wong, WWL Au, X Zhou, Y Benjamini, Y Liu, Y Liu, Y Liu, Y-B Sun, Y-Y Shen, Yuan Liu, Z Yang, Z Yang   +64 more
core   +1 more source

Phylogenetic relationships of the Emmericiidae (Caenogastropoda: Rissooidea) [PDF]

Folia Malacologica, 2013
The phylogenetic relationships of the monogeneric rissooid family Emmericiidae Brusina, 1870 are unclear. The single genus Emmericia Brusina, 1870 occurs along the Adriatic coast from NE Italy to southern Croatia. It is characterised by the peculiar anatomy of the male genitalia (tri-lobed penis, bifurcate flagellum and penial gland).
Szarowska, Magdalena, Falniowski, Andrzej   +1 more
openaire   +2 more sources

Structural Characterization and AI‐Enhanced Modeling of a Broadly Neutralizing Camelid Antibody Against SARS‐CoV‐2 Variants

Advanced Therapeutics, EarlyView.
This study characterizes a camelid antibody (B10) with potent neutralizing activity against SARS‐CoV‐2 Wildtype and Omicron variants. Through binding assays, epitope mapping, pseudovirus neutralization, and AI‐driven modeling, the antibody is shown to target conserved RBD regions in a closed Spike conformation.
Katja Hanack, Urszula Orzeł, Anja Schlör, Sourabh Mehta, Anandi Krishnan, Slawomir Filipek, Rushika Patel, Madhvi Joshi, Markus Hoffmann, Stefan Pöhlmann, Chaitanya Joshi, Dorian Liepmann, Ramasamy Paulmurugan, Venkatesan Renugopalakrishnan   +13 more
wiley   +1 more source

Evidence of strong stabilizing effects on the evolution of boreoeutherian (Mammalia) dental proportions. [PDF]

, 2019
The dentition is an extremely important organ in mammals with variation in timing and sequence of eruption, crown morphology, and tooth size enabling a range of behavioral, dietary, and functional adaptations across the class.
Archibald J. D., Archibald J. D., Bergqvist L. P., Butler P. M., Chaffee R. G., Clark J., Clemens W. A., Cuvier G., Evans A. R., Fortelius M., Gingerich P. D., Harmon L., Janis C. M., Janis C. M., Kay R. F., Kurtén B., Lucas P. W., Lucas P. W., Monson T. A., Nowak R. N., Orme D., Qiu Z. X., R Core Team, Revelle W., Tomiya S., Ungar P. S., Ungar P. S.   +26 more
core   +6 more sources

Pre‐Administration of Akkermansia Muciniphila Prevents the Development of Severe Acute Graft‐Versus‐Host Disease in Systemic Organs

Advanced Science, EarlyView.
Akkermansia muciniphila, a next‐generation probiotic, alleviates acute graft‐versus‐host disease (aGvHD) following allogeneic hematopoietic stem cell transplantation (HSCT) by providing protective effects across multiple organs. Pre‐colonization with A.
Jeong‐Eun Han, Dae‐Seong Lee, Su‐Won Jeong, Ji‐Hyun Yun, Seomin Kang, Seoyoung Jang, EunAh Lee, Ju Hye Baek, Che Ok Jeon, Jin‐Woo Bae   +9 more
wiley   +1 more source

The complete mitochondrial genome of Siganus virgatus Valenciennes (Siganidae: Acanthuriformes)

Mitochondrial DNA. Part B. Resources
Siganus virgatus Valenciennes 1835 is an essential species for examining reef ecosystems; however, its mitochondrial genome has not been studied. In this research, the mitogenome of S. virgatus was sequenced and characterized.
Hoang Danh Nguyen, Hoang Dang Khoa Do, Thanh-Nam Nguyen, Minh Thiet Vu   +3 more
doaj   +1 more source

A generalized framework for analyzing taxonomic, phylogenetic, and functional community structure based on presence-absence data [PDF]

, 2018
Community structure as summarized by presence–absence data is often evaluated via diversity measures by incorporating taxonomic, phylogenetic and functional information on the constituting species.
Pavoine, Sandrine, Podani, János, Ricotta, Carlo   +2 more
core   +3 more sources

Plant Virus‐Induced Inheritable Apoptosis Drives Reproductive Costs in Female Insect Vectors to Balance Viral Biparental Transmission

Advanced Science, EarlyView.
Rice gall dwarf virus (RGDV), transmitted biparentally by leafhopper vector to their offspring, exploits the capsid protein to induce inheritable ovarian apoptosis via insulin‐driven PI3K/AKT/FoxO signaling axis. This mechanism enhances infection but reduces female reproductive fitness, causing inefficient maternal transmission.
Haibo Wu, Wenqiang Wan, Qingquan Liang, Hengsong Yang, Chengcong Lu, Taiyun Wei, Qian Chen   +6 more
wiley   +1 more source