Results 151 to 160 of about 422,394 (335)

AI‐Driven De Novo Design of Ultra Long‐Acting GLP‐1 Receptor Agonists

Advanced Science, EarlyView.
De novo GLP‐1RAs can be computationally designed to exhibit extended half‐life and superior efficacy compared to Semaglutide. Abstract Peptide drugs have revolutionized modern therapeutics, offering novel treatment avenues for various diseases. Nevertheless, low design efficacy, time consumption, and high cost still hinder peptide drug design and ...
Ting Wei, Jiating Ma, Xiaochen Cui, Jiahui Lin, Zhuoqi Zheng, Liu Cheng, Taiying Cui, Xiaoqian Lin, Junjie Zhu, Xuyang Ran, Xiaokun Hong, Luke Johnston, Zhangsheng Yu, Haifeng Chen   +13 more
wiley   +1 more source

The phylogenetic inter relationships of the Recent crinoids

, 1910
Austin Hobart Clark
openalex   +2 more sources

Transduction of inositol-fermenting ability demonstrating phylogenetic relationships among strains ofSalmonella typhimurium [PDF]

, 1980
D. C. Old, P. F. H. Dawes, Ruth M. Barker   +2 more
openalex   +1 more source

Protein Spatial Structure Meets Artificial Intelligence: Revolutionizing Drug Synergy–Antagonism in Precision Medicine

Advanced Science, EarlyView.
This review comprehensively examines the applications of protein three‐dimensional structures and artificial intelligence in investigating drug synergistic and antagonistic effects. The research findings provide compelling evidence for the precision treatment of cancer and metabolic diseases, thereby promoting the development of personalized medicine ...
Anqi Lin, Chang Che, Aimin Jiang, Chang Qi, Antonino Glaviano, Zhijie Zhao, Zhirou Zhang, Zaoqu Liu, Ziyao Zhou, Quan Cheng, Shuofeng Yuan, Peng Luo   +11 more
wiley   +1 more source

The Phylogenetic Relationship of Lamiinae (Coleoptera: Cerambycidae) Using Mitochondrial Genomes. [PDF]

Genes (Basel), 2023
Li K, Yu SW, Hu H, Feng YF, Storey KB, Ma Y, Zhang JY, Yu DN.   +7 more
europepmc   +1 more source

Spatiotemporal Transcriptomic Atlas Reveals the Regulatory Mechanisms Underlying Early Inflorescence Development and Sex Differentiation in Spinach

Advanced Science, EarlyView.
High‐resolution spatiotemporal transcriptomic data from male and female spinach inflorescences across four key stages first reveal the sex differentiation initiates at the four‐leaf stage and is governed by epigenetic regulation via the SpMSI1‐SpHDT2 complex.
Chen You, Hao Yang, Yueyan Zhao, Xiaoning Wang, Shuaijie Wei, Ning Chen, Yulan Zhang, Luxian Liu, Wei Qian, Shufen Li, Wujun Gao   +10 more
wiley   +1 more source

The complete chloroplast genome of Chrysoglossum ornatum (Epidendroideae, Orchidaceae) and its phylogenetic analysis

Mitochondrial DNA. Part B. Resources
Chrysoglossum ornatum Blume, the type species of Chrysoglossum Blume, belongs to the tribe Collabieae of the subfamily Epidendroideae of Orchidaceae. In this study, we sequenced, assembled, and analyzed the complete chloroplast genome of C. ornatum.
Cheng-Jiang Tan, Rong-Rong Yan, Ping Yu, Guang-Qin Lu, Wei Wu, Guo-Xiong Hu   +5 more
doaj   +1 more source

Phylogenetic relationships of plesiadapiform-tarsiiform primates

, 1978
Leonard Krishtalka, Jeffrey H. Schwartz
openalex   +2 more sources

Comparative Single‐Cell Transcriptomic Landscape Reveals the Regulatory Mechanisms of Lactation during Selective Breeding in Asian Water Buffalo

Advanced Science, EarlyView.
In this study, a comprehensive single‐cell transcriptome atlas of river and swamp buffalo, encompassing 12 tissues and 397,011 cells, is constructed. Differential expression analyses identify metabolic and secretory tissues and cell types that mediate the divergence of milk production.
Dongmei Dai, Jingfang Si, Li Jiang, Bo Han, Kailai Wang, Xue Wang, Shihui Yan, Yichang Yin, Wei Chen, Huaming Mao, Alfredo Pauciullo, Shang‐Tong Li, Lingzhao Fang, Yi Zhang   +13 more
wiley   +1 more source

Characterization of the complete chloroplast genome of Helicteres hirsuta Lour. 1790 (Helicteriodeae: Malvaceae)

Mitochondrial DNA. Part B. Resources
Helicteres hirsuta Lour. 1790 is a precious medicinal plant species, especially for treating chronic liver diseases. Genomic data on H. hirsuta are limited. Therefore, this current study aimed to characterize the chloroplast genome of H.
Hoang Danh Nguyen, Minh Thiet Vu, Hoang Dang Khoa Do   +2 more
doaj   +1 more source