Results 161 to 170 of about 2,043,845 (347)

Akkermansia muciniphila‐Derived N‐Acetylspermidine Modulates the Localization of Intestinal α1,2‐Fucosylated Proteins to Maintain Gut Homeostasis

Advanced Science, EarlyView.
This study demonstrates that Akkermansia muciniphila alleviates colitis by enhancing intestinal α1,2‐fucosylation through its metabolite N‐acetylspermidine. Mechanistically, N‐acetylspermidine‐induced PIM1 inhibition promotes HDAC2‐mediated reduction of chromatin accessibility at TP73, thereby upregulating C1GALT1C1 to boost α1,2‐fucosylation.
Ye Yao, Zhangming Pei, Yuanyuan Dai, Yinghan Chen, Zepeng Chang, Hongchao Wang, Jianxin Zhao, Hao Zhang, Qixiao Zhai, Wenwei Lu, Wei Chen   +10 more
wiley   +1 more source

Peptide Hormone‐Mediated Regulation of Plant Development and Environmental Adaptability

Advanced Science, EarlyView.
In this review, recent advances in understanding the roles of plant peptide hormones in regulating growth, reproduction, and environmental adaptability are systematically summarized. It further elucidates the challenges in studying these peptides, such as their low abundance, functional redundancy, and complex signaling mechanisms, and highlights their
Xin Li, Liping Zhu, Huiqin Wang, Xin Zhou, Manhong Wang, Libei Li, Feng Liu, Jie Sun, Guanghui Xiao   +8 more
wiley   +1 more source

Reliable estimation of tree branch lengths using deep neural networks.

PLoS Computational Biology
A phylogenetic tree represents hypothesized evolutionary history for a set of taxa. Besides the branching patterns (i.e., tree topology), phylogenies contain information about the evolutionary distances (i.e. branch lengths) between all taxa in the tree,
Anton Suvorov, Daniel R Schrider
doaj   +1 more source

Taxonomic colouring of phylogenetic trees of protein sequences

BMC Bioinformatics, 2006
Background Phylogenetic analyses of protein families are used to define the evolutionary relationships between homologous proteins. The interpretation of protein-sequence phylogenetic trees requires the examination of the taxonomic properties of the ...
Andrade-Navarro Miguel A, Reynaud Emmanuel G, Palidwor Gareth   +2 more
doaj   +1 more source

Rapid Evaluation of Least-Squares and Minimum-Evolution Criteria on Phylogenetic Trees [PDF]

, 1998
David Bryant, Peter J. Waddell
openalex   +1 more source

Florigen and Florigen‐Like Genes Regulate Temperature‐Responsive Flowering in Tomato

Advanced Science, EarlyView.
This study uncovers that FLOWERING LOCUS T‐Like 2 (FTL2) and SINGLE‐FLOWER TRUSS (SFT) antagonistically regulate temperature‐responsive flowering in the tomato shoot apical meristem. High temperature induces floral repressor FTL2, which directly inhibits SFT to delay short‐day floral transition, while SFT reciprocally inhibits FTL2 to promote flowering.
Jia Song, Shiqi Zhao, Siyu Fang, Xiaotian Wang, Shuai Sun, Baohua Li, Ren Li, Lu Liu, Xia Cui   +8 more
wiley   +1 more source

Using Plant DNA Barcodes and Functional Traits to Assess Community Assembly of Quercus Forests at Different Scales in the Semiarid Loess Plateau of China

Ecology and Evolution
Trait and evolutionary differences among coexisting species are increasingly used to comprehend the processes shaping communities. However, they do not consistently yield congruent insights due to methodological limitations and scale dependence ...
YongFu Chai, TingTing Tian, Luyao Wang, Junxin Wei, Yao Xu, Peiliang Liu, Chengcheng Xiang, Ming Yue   +7 more
doaj   +1 more source

Multiple local maxima for likelihoods of phylogenetic trees: a simulation study [PDF]

, 1999
James S. Rogers, David L. Swofford
openalex   +1 more source

AI‐Driven De Novo Design of Ultra Long‐Acting GLP‐1 Receptor Agonists

Advanced Science, EarlyView.
De novo GLP‐1RAs can be computationally designed to exhibit extended half‐life and superior efficacy compared to Semaglutide. Abstract Peptide drugs have revolutionized modern therapeutics, offering novel treatment avenues for various diseases. Nevertheless, low design efficacy, time consumption, and high cost still hinder peptide drug design and ...
Ting Wei, Jiating Ma, Xiaochen Cui, Jiahui Lin, Zhuoqi Zheng, Liu Cheng, Taiying Cui, Xiaoqian Lin, Junjie Zhu, Xuyang Ran, Xiaokun Hong, Luke Johnston, Zhangsheng Yu, Haifeng Chen   +13 more
wiley   +1 more source

Species richness and resource availability: A phylogenetic analysis of insects associated with trees [PDF]

, 1999
Colleen K. Kelly, T. R. E. Southwood
openalex   +1 more source